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BGC0002810Hybrid

Hangtaimycin;Deoxyhangtaimycin

Producing organism
Streptomyces spectabilis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
23
DOI
MIBiG entry
View on MIBiG ↗
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C50H61N7O11935.44 Da

Gene Cluster Map11 genes · 76,130 bp

KSKSKSKSAKSKSAKSKSKSKSKSKSAAAA20 kb76.1 kb visible · 76,130 bp total
Biosynthetic (core)
Biosynthetic (additional)
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TdTrans-AT docking
DH2Dehydratase (DH2)
ECHEnoyl-CoA hydratase
MTMethyltransferase
GNATN-acetyltransferase
ACPβACP (β-branching)

Pathway Graphsteps arranged in biosynthetic order

23 steps · 22 edges
Step 1Load
htm1
Trans-AT
Step 2M1
htm1
Trans-AT
Step 3M2
htm1
Module Skip
Step 4M3
htm1
Inactive: KS
Step 5M4
htm1
Trans-AT
Step 6M5
htm2
+Alanine
Step 7M6
htm2
Trans-AT
Step 8M7
htm2
Inactive: KS
Step 9M8
htm2
+Glycine
Step 10M9
htm2
Trans-AT
Step 11M10
htm2;htm3
Trans-AT
Step 12
htm3
Step 13
htm3
Step 14M11
htm3
Trans-AT
Step 15M12
htm3
Trans-AT
Step 16M13
htm3
Trans-AT
Step 17M14
htm3
Inactive: KS
Step 18M15
htm4
+Serine
Step 19M16
htm4
+Threonine
Step 20M17
htm5
+Threonine
Step 21M18
htm5
+Tryptophan
Step 22
?
Step 23
htm11
+2810(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12810-1htm1Loading
O=C(O)C{'transAT': ['htm10', 'Malon…
22810-2htm1M1
2810-1
from: 2810-1
C/C=C/C(O)=O{'transAT': ['htm10', 'Malon…
32810-3htm1M2
2810-2
from: 2810-2
C/C=C/C(O)=O{‘ModuleSkip’: ‘Skip’}
42810-4htm1M3
2810-3
from: 2810-3
C/C=C/C(O)=O{'Inactive': ['KS']}
52810-5htm1M4
2810-4
from: 2810-4
O=C(O)/C=C\C=C\C{'transAT': ['htm10', 'Malon…
62810-6htm2M5
2810-5;Alanine
from: 2810-5
O=C(N[C@H](C(O)=O)C)/C=C\C=C\C—
72810-7htm2M6
2810-6
from: 2810-6
O=C(N[C@H](/C=C(C(O)=O)\C)C)/C=C\C=C\C{'transAT': ['htm10', 'Malon…
82810-8htm2M7
2810-7
from: 2810-7
O=C(N[C@H](/C=C(C(O)=O)\C)C)/C=C\C=C\C{'Inactive': ['KS']}
92810-9htm2M8
2810-8;Glycine
from: 2810-8
O=C(N[C@H](/C=C(C(NCC(O)=O)=O)\C)C)/C=C\C=C\C—
102810-10htm2M9
2810-9
from: 2810-9
O=C(N[C@H](/C=C(C(NC[C@H](O)CC(O)=O)=O)\C)C)/C=C\C=C\C{'transAT': ['htm10', 'Malon…
112810-11htm2;htm3M10
2810-10
from: 2810-10
O=C(N[C@H](/C=C(C(NC[C@H](O)CC(CC(O)=O)=O)=O)\C)C)/C=C\C=C\C{'transAT': ['htm10', 'Malon…
122810-12htm3—
2810-11
from: 2810-11
O=C(N[C@H](/C=C(C(NC[C@H](O)CC(CC(O)=O)(O)CC(O)=O)=O)\C)C)/C=C\C=C\C—
132810-13htm3—
2810-12
from: 2810-12
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CC(O)=O)=CC1=O)=O)\C)C)/C=C\C=C\C—
142810-14htm3M11
2810-13
from: 2810-13
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCCC(O)=O)=CC1=O)=O)\C)C)/C=C\C=C\C{'transAT': ['htm10', 'Malon…
152810-15htm3M12
2810-14
from: 2810-14
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCC/C=C/C(O)=O)=CC1=O)=O)\C)C)/C=C\C=C\C{'transAT': ['htm10', 'Malon…
162810-16htm3M13
2810-15
from: 2810-15
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCC/C=C/C=C/C(O)=O)=CC1=O)=O)\C)C)/C=C\C=C\C{'transAT': ['htm10', 'Malon…
172810-17htm3M14
2810-16
from: 2810-16
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCC/C=C/C=C/C(O)=O)=CC1=O)=O)\C)C)/C=C\C=C\C{'Inactive': ['KS']}
182810-18htm4M15
2810-17;Serine
from: 2810-17
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCC/C=C/C=C/C(NC(C(O)=O)=C)=O)=CC1=O)=O)\C)C)/C=C\C=C\C—
192810-19htm4M16
2810-18;Threonine
from: 2810-18
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCC/C=C/C=C/C(NC(C(NC([C@@H](OC)C)C(O)=O)=O)=C)=O)=CC1=O)=O)\C)C)/C=C\C=C\C—
202810-20htm5M17
2810-19;Threonine
from: 2810-19
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCC/C=C/C=C/C(NC(C(NC([C@@H](OC)C)C(N/C(C(O)=O)=C\C)=O)=O)=C)=O)=CC1=O)=O)\C)C)/C=C\C=C\C—
212810-21htm5M18
2810-20;Tryptophan
from: 2810-20
O=C(N[C@H](/C=C(C(NC[C@H](O1)CC(CCC/C=C/C=C/C(NC(C(NC([C@@H](OC)C)C(N/C(C(N([C@H](CC2=CNC3=C2C=CC=C3)C(O)=O)C)=O)=C\C)=O)=O)=C)=O)=CC1=O)=O)\C)C)/C=C\C=C\C—
222810(1)?—
2810-21
from: 2810-21
O=C(C(NC(/C=C/C=C/CCCC1=CC(O[C@@H](CNC(/C(C)=C/[C@H](C)NC(/C=C\C=C\C)=O)=O)C1)=O)=O)=C)N[C@H](C(N(/C(C(N([C@@H]2CC3=CNC4=C3C=CC=C4)C)=O)=C\C)C2=O)=O)[C@H](C)OC—
232810(2)htm11—
2810(1)
O=C(C(NC(/C=C/C=C/CCCC1=CC(O[C@@H]([C@H](O)NC(/C(C)=C/[C@H](C)NC(/C=C\C=C\C)=O)=O)C1)=O)=O)=C)N[C@H](C(N(/C(C(N([C@@H]2CC3=CNC4=C3C=CC=C4)C)=O)=C\C)C2=O)=O)[C@H](C)OC—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture