NPdia

BGC0002808PKS

N-coronafacoyl-L-isoleucine

Producing organism: Streptomyces scabiei 87.22
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Type I)
Total steps: 11
DOI: 10.1007/s10482-017-1009-1
MIBiG entry: View on MIBiG ↗

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N-coronafacoyl-L-isoleucine

Biosynthetic (core)

Biosynthetic (additional)

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Adenylation (A)

Acyl carrier (ACP)

Thioesterase (TE)

Docking C-term

11 steps · 10 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`2808-1`	SCAB_79601, SCAB_79611, SCAB_79621, SCAB_79631, SCAB_79641	—	?;Malonyl-CoA	`OC(C1=CCCC1)=O`	—
2	`2808-2`	Start	—	Hydroxybutyryl-CoA	`C[C@@H](CC([R])=O)O`	—
3	`2808-3`	SCAB_79711	—	2808-2 from: 2808-2	`C/C=C/C([R])=O`	—
4	`2808-4`	SCAB_79701	—	2808-3 from: 2808-3	`CCCC([R])=O`	—
5	`2808-5`	SCAB_79651	—	2808-1;2808-4 from: 2808-1, 2808-4	`CC[C@@H](C(O)=O)CC1=CCCC1`	—
6	`2808-6`	SCAB_79661	—	2808-5;Malonyl-CoA from: 2808-5	`CC[C@@H](C(CC(O)=O)=O)CC1=CCCC1`	{'Inactive': ['ER']}
7	`2808-7`	SCAB_79661	TE	2808-6 from: 2808-6	`[H][C@@]12[C@@](CCC2)([H])C(C(O)=O)C[C@H](CC)C1`	{'Domain_Reuse': ['SCAB_7966…
8	`2808-8`	SCAB_79681?	—	2808-7 from: 2808-7	`[H][C@@]12[C@@](CCC2)([H])C(C(O)=O)=C[C@H](CC)C1`	—
9	`2808-9`	SCAB_79691	—	2808-8 from: 2808-8	`[H][C@@]12[C@@](CC[C@H]2O)([H])C(C(O)=O)=C[C@H](CC)C1`	—
10	`2808-10`	SCAB_79721	—	2808-9 from: 2808-9	`[H][C@@]12[C@@](CCC2=O)([H])C(C(O)=O)=C[C@H](CC)C1`	—
11	`2808`	SCAB_79671	—	2808-10 from: 2808-10	`[H][C@@]12[C@@](CCC2=O)([H])C(C(NC(C(O)=O)[C@@H](C)CC)=O)=C[C@H](CC)C1`	—

Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture