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BGC0002789PKS

Filipin;Pentamycin

Producing organism
Streptomyces lavendulae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS(Unknown)
Total steps
18
DOI
MIBiG entry
—
Loading…
C35H58O12670.39 Da

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
E2C11_02950
+Acetyl-CoA
Inactive: KS
Step 2M1
E2C11_02950
+Malonyl-CoA
Step 3M2
E2C11_02950
+Malonyl-CoA
Step 4M3
E2C11_02950
+Malonyl-CoA
Step 5M4
E2C11_02950
+Malonyl-CoA
Step 6M5
E2C11_02945
+Malonyl-CoA
Step 7M6
E2C11_02945
+Methylmalonyl-CoA
Step 8M7
E2C11_02940
+Malonyl-CoA
Inactive: DH
Step 9M8
E2C11_02935
+Malonyl-CoA
Step 10M9
E2C11_02935
+Malonyl-CoA
Step 11M10
E2C11_02935
+Malonyl-CoA
Step 12M11
E2C11_02935
+Malonyl-CoA
Step 13M12
E2C11_02930
+Malonyl-CoA
Step 14M13
E2C11_02930
+Hexylmalonyl-CoA
Step 15TE
E2C11_02930
Step 16
E2C11_02915
Step 17
E2C11_02920
Step 18
E2C11_02955
+2789(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12789-1E2C11_02950Loading
Acetyl-CoA
O=C(C)O{'Inactive':['KS']}
22789-2E2C11_02950M1
2789-1;Malonyl-CoA
from: 2789-1
O[C@H](C)CC(O)=O—
32789-3E2C11_02950M2
2789-2;Malonyl-CoA
from: 2789-2
O[C@H](C)C/C=C/C(O)=O—
42789-4E2C11_02950M3
2789-3;Malonyl-CoA
from: 2789-3
O[C@H](C)C/C=C/C=C/C(O)=O—
52789-5E2C11_02950M4
2789-4;Malonyl-CoA
from: 2789-4
O[C@H](C)C/C=C/C=C/C=C/C(O)=O—
62789-6E2C11_02945M5
2789-5;Malonyl-CoA
from: 2789-5
O[C@H](C)C/C=C/C=C/C=C/C=C/C(O)=O—
72789-7E2C11_02945M6
2789-6;Methylmalonyl-CoA
from: 2789-6
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O—
82789-8E2C11_02940M7
2789-7;Malonyl-CoA
from: 2789-7
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)CC(O)=O{'Inactive':['DH']}
92789-9E2C11_02935M8
2789-8;Malonyl-CoA
from: 2789-8
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)CC(O)=O—
102789-10E2C11_02935M9
2789-9;Malonyl-CoA
from: 2789-9
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
112789-11E2C11_02935M10
2789-10;Malonyl-CoA
from: 2789-10
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
122789-12E2C11_02935M11
2789-11;Malonyl-CoA
from: 2789-11
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
132789-13E2C11_02930M12
2789-12;Malonyl-CoA
from: 2789-12
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
142789-14E2C11_02930M13
2789-13;Hexylmalonyl-CoA
from: 2789-13
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C(C(O)=O)CCCCCC—
152789-15E2C11_02930TE
2789-14
from: 2789-14
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/C[C@@H](C)OC(C1CCCCCC)=O—
162789-16E2C11_02915—
2789-15
from: 2789-15
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1CCCCCC)=O—
172789(1)E2C11_02920—
2789-16
from: 2789-16
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1[C@H](O)CCCCC)=O—
182789(2)E2C11_02955—
2789(1)
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1[C@H](O)CCCCC)=O—
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