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BGC0002788PKS

14-hydroxyisochainin

Producing organism
Streptomyces peucetius subsp. caesius ATCC 27952
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Modular type I)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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14-hydroxyisochainin
C33H54O11626.37 Da

Gene Cluster Map34 genes · 107,104 bp

20 kb107.1 kb visible · 107,104 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ECHEnoyl-CoA hydratase

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
?
+Acetyl-CoA
Inactive: KS
Step 2M1
?
+Malonyl-CoA
Step 3M2
?
+Malonyl-CoA
Step 4M3
?
+Malonyl-CoA
Step 5M4
?
+Malonyl-CoA
Step 6M5
?
+Malonyl-CoA
Step 7M6
?
+Methylmalonyl-CoA
Step 8M7
?
+Malonyl-CoA
Inactive: DH
Step 9M8
?
+Malonyl-CoA
Step 10M9
?
+Malonyl-CoA
Step 11M10
?
+Malonyl-CoA
Step 12M11
?
+Malonyl-CoA
Step 13M12
?
+Malonyl-CoA
Step 14M13
?
+Butylmalonyl-CoA
Step 15TE
?
Step 16
CGZ69_28880
Step 17
CGZ69_28840
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12788-1?Loading
Acetyl-CoA
O=C(C)O{'Inactive': ['KS']}
22788-2?M1
2788-1;Malonyl-CoA
from: 2788-1
O[C@H](C)CC(O)=O—
32788-3?M2
2788-2;Malonyl-CoA
from: 2788-2
O[C@H](C)C/C=C/C(O)=O—
42788-4?M3
2788-3;Malonyl-CoA
from: 2788-3
O[C@H](C)C/C=C/C=C/C(O)=O—
52788-5?M4
2788-4;Malonyl-CoA
from: 2788-4
O[C@H](C)C/C=C/C=C/C=C/C(O)=O—
62788-6?M5
2788-5;Malonyl-CoA
from: 2788-5
O[C@H](C)C/C=C/C=C/C=C/C=C/C(O)=O—
72788-7?M6
2788-6;Methylmalonyl-CoA
from: 2788-6
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O—
82788-8?M7
2788-7;Malonyl-CoA
from: 2788-7
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)CC(O)=O{'Inactive': ['DH']}
92788-9?M8
2788-8;Malonyl-CoA
from: 2788-8
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)CC(O)=O—
102788-10?M9
2788-9;Malonyl-CoA
from: 2788-9
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
112788-11?M10
2788-10;Malonyl-CoA
from: 2788-10
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
122788-12?M11
2788-11;Malonyl-CoA
from: 2788-11
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
132788-13?M12
2788-12;Malonyl-CoA
from: 2788-12
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
142788-14?M13
2788-13;Butylmalonyl-CoA
from: 2788-13
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C(C(O)=O)CCCC—
152788-15?TE
2788-14
from: 2788-14
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/C[C@@H](C)OC(C1CCCC)=O—
162788-16CGZ69_28880—
2788-15
from: 2788-15
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1CCCC)=O—
172788CGZ69_28840—
2788-16
from: 2788-16
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)[C@H](O)[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1CCCC)=O—
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