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BGC0002735Hybrid

Incarnatapeptin A;Incarnatapeptin B;Dentigerumycin F;Dentigerumycin G

Producing organism
Streptomyces incarnatus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown);NRPS (Type I)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map20 genes · 56,157 bp

CAECACAECACACAKSATKSATKSATERKSATCAER10 kb56.2 kb visible · 56,157 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
EEpimerization (E)
DnDocking N-term
DcDocking C-term
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1M1
ABB07_39175
+Malonyl-CoA
Step 2M2
ABB07_39180
+3-Hydroxybutyryl-…
Inactive: DH
Step 13M2
ABB07_39180
+Ethylmalonyl-CoA
Inactive: DH
Step 3M3
ABB07_39185
+Malonyl-CoA
Step 14M3
ABB07_39185
+Malonyl-CoA
Step 4M4
ABB07_39190
+Methylmalonyl-CoA
Step 15M4
ABB07_39190
+Methylmalonyl-CoA
Step 5M5
ABB07_39195
+Hydroxyleucine
Step 16M5
ABB07_39195
+Hydroxyleucine
Step 6M6
ABB07_39125
+D-Piperazic acid
Step 17M6
ABB07_39125
+D-Piperazic acid
Step 7M7
ABB07_39125
+N-hydroxy-L-alani…
Step 18M7
ABB07_39125
+N-hydroxy-L-alani…
Step 8M8
ABB07_39130
+D-Piperazic acid
Step 19M8
ABB07_39130
+D-Piperazic acid
Step 9M9
ABB07_39130
+L-Piperazic acid
Step 20M9
ABB07_39130
+L-Piperazic acid
Step 10
?
Step 11M10
ABB07_39135
+Threonine
Step 21
?
Step 12TE
ABB07_39135
Step 22
?
+2735(3)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12735-1ABB07_39175M1
Malonyl-CoA
CC(O)=O—
22735-2ABB07_39180M2
2735-1;3-Hydroxybutyryl-CoA
from: 2735-1
C/C=C(C(O)=O)\[C@H](O)C{'Inactive': ['DH']}
32735-3ABB07_39185M3
2735-2;Malonyl-CoA
from: 2735-2
C/C=C(CCC(O)=O)\[C@H](O)C—
42735-4ABB07_39190M4
2735-3;Methylmalonyl-CoA
from: 2735-3
O=C(O)C([C@]1(O)CC[C@H]([C@H](O)C)[C@@H](C)O1)C—
52735-5ABB07_39195M5
2735-4;Hydroxyleucine
from: 2735-4
O=C([C@@H](NC([C@@](C)(O)[C@]12O[C@H](C)[C@@H](CC2)[C@@H](C)O1)=O)[C@@H](O)C(C)C)O—
62735-6ABB07_39125M6
2735-5;D-Piperazic acid
from: 2735-5
O=C([C@@H]1N(NCCC1)C([C@@H](NC([C@@](C)(O)[C@]23O[C@H](C)[C@@H](CC3)[C@@H](C)O2)=O)[C@@H](O)C(C)C)=O)O—
72735-7ABB07_39125M7
2735-6;N-hydroxy-L-alanine
from: 2735-6
O=C(O)[C@H](C)N(O)C([C@@H]1N(NCCC1)C([C@@H](NC([C@@](C)(O)[C@]23O[C@H](C)[C@@H](CC3)[C@@H](C)O2)=O)[C@@H](O)C(C)C)=O)=O—
82735-8ABB07_39130M8
2735-7;D-Piperazic acid
from: 2735-7
O=C(N(NCCC1)[C@H]1C(O)=O)[C@H](C)N(O)C([C@@H]2N(NCCC2)C([C@@H](NC([C@@](C)(O)[C@]34O[C@H](C)[C@@H](CC4)[C@@H](C)O3)=O)[C@@H](O)C(C)C)=O)=O—
92735-9ABB07_39130M9
2735-8;L-Piperazic acid
from: 2735-8
O=C(N(NCCC1)[C@H]1C(N(NCCC2)[C@@H]2C(O)=O)=O)[C@H](C)N(O)C([C@@H]3N(NCCC3)C([C@@H](NC([C@@](C)(O)[C@]45O[C@H](C)[C@@H](CC5)[C@@H](C)O4)=O)[C@@H](O)C(C)C)=O)=O—
102735(1)?—
2735-9
from: 2735-9
O=C(N(NCCC1)[C@H]1C(N(NCCC2)[C@@H]2C(O)=O)=O)[C@H](C)N(O)C([C@@H]3N(NCCC3)C([C@@H](NC([C@@](C)(O)[C@]45O[C@H](C)[C@@H](CC5)[C@@H](C)O4)=O)[C@@H](O)C(C)C)=O)=O—
112735-10ABB07_39135M10
2735-9;Threonine
from: 2735-9
O=C(N(NCCC1)[C@H]1C(N(NCCC2)[C@@H]2C(O)=O)=O)[C@H](C)N(O)C([C@@H]3N(NCCC3)C([C@H]([C@H](C(C)C)OC(C(C(C)C)NO)=O)NC([C@@](C)(O)[C@]45O[C@H](C)[C@@H](CC5)[C@@H](C)O4)=O)=O)=O—
122735(2)ABB07_39135TE
2735-10
from: 2735-10
O=C(N(NCCC1)[C@H]1C(N(NCCC2)[C@@H]2C(N3)=O)=O)[C@H](C)N(O)C([C@@H]4N(NCCC4)C([C@H]([C@H](C(C)C)OC(C3C(C)C)=O)NC([C@@](C)(O)[C@]56O[C@H](C)[C@@H](CC6)[C@@H](C)O5)=O)=O)=O—
132735-11ABB07_39180M2
2735-1;Ethylmalonyl-CoA
from: 2735-1
C/C=C(C(O)=O)\CC{'Inactive': ['DH']}
142735-12ABB07_39185M3
2735-11;Malonyl-CoA
from: 2735-11
C/C=C(CCC(O)=O)\CC—
152735-13ABB07_39190M4
2735-12;Methylmalonyl-CoA
from: 2735-12
OC([C@H](C)[C@]1(O)O[C@H](C)[C@@H](CC)[C@@H](C)C1)=O—
162735-14ABB07_39195M5
2735-13;Hydroxyleucine
from: 2735-13
O=C([C@@H](NC([C@@](C)(O)[C@]1(O)O[C@H](C)[C@@H](CC)[C@@H](C)C1)=O)[C@@H](O)C(C)C)O—
172735-15ABB07_39125M6
2735-14;D-Piperazic acid
from: 2735-14
O=C([C@@H]1N(NCCC1)C([C@@H](NC([C@@](C)(O)[C@]2(O)O[C@H](C)[C@@H](CC)[C@@H](C)C2)=O)[C@@H](O)C(C)C)=O)O—
182735-16ABB07_39125M7
2735-15;N-hydroxy-L-alanine
from: 2735-15
O=C(O)[C@H](C)N(O)C([C@@H]1N(NCCC1)C([C@@H](NC([C@@](C)(O)[C@]2(O)O[C@H](C)[C@@H](CC)[C@@H](C)C2)=O)[C@@H](O)C(C)C)=O)=O—
192735-17ABB07_39130M8
2735-16;D-Piperazic acid
from: 2735-16
O=C(N(NCCC1)[C@H]1C(O)=O)[C@H](C)N(O)C([C@@H]2N(NCCC2)C([C@@H](NC([C@@](C)(O)[C@]3(O)O[C@H](C)[C@@H](CC)[C@@H](C)C3)=O)[C@@H](O)C(C)C)=O)=O—
202735-18ABB07_39130M9
2735-17;L-Piperazic acid
from: 2735-17
O=C(N(NCCC1)[C@H]1C(N(NCCC2)[C@@H]2C(O)=O)=O)[C@H](C)N(O)C([C@@H]3N(NCCC3)C([C@@H](NC([C@@](C)(O)[C@]4(O)O[C@H](C)[C@@H](CC)[C@@H](C)C4)=O)[C@@H](O)C(C)C)=O)=O—
212735(3)?—
2735-18
from: 2735-18
O=C(N(NCCC1)[C@H]1C(N(NCCC2)[C@@H]2C(O)=O)=O)[C@H](C)N(O)C([C@@H]3N(NCCC3)C([C@@H](NC([C@@](C)(O)[C@]4(O)O[C@H](C)[C@@H](CC)[C@@H](C)C4)=O)[C@@H](O)C(C)C)=O)=O—
222735(4)?—
2735(3)
O=C(N(NCCC1)[C@H]1C(N(NCCC2)[C@@H]2C(N)=O)=O)[C@H](C)N(O)C([C@@H]3N(NCCC3)C([C@@H](NC([C@@](C)(O)[C@]4(O)O[C@H](C)[C@@H](CC)[C@@H](C)C4)=O)[C@@H](O)C(C)C)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture