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BGC0002702NRPS

GP6738

Producing organism
Streptomyces sp. WAC 06738
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map22 genes · 57,454 bp

ACACAECAECAECAECAECAECAXA10 kb57.5 kb visible · 57,454 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
ECHEnoyl-CoA hydratase
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1M1
DMB38_33845
+3,5-dihydroxyphen…
Step 2M2
DMB38_33845
+3,5-dihydroxyphen…
Step 3M3
DMB38_33845
+Valine
Step 4M4
DMB38_33850
+Tryptophan
Step 5M5
DMB38_33855
+3,5-dihydroxyphen…
Step 6M6
DMB38_33860
+4-hydroxyphenylgl…
Step 7M7
DMB38_33860
+3,5-dihydroxyphen…
Step 8M8
DMB38_33860
+Tyrosine
Step 9M9
DMB38_33865
+3,5-dihydroxyphen…
Step 10TE
DMB38_33865
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12702-1DMB38_33845M1
3,5-dihydroxyphenylglycine
OC(C(C1=CC(O)=CC(O)=C1)N)=O—
22702-2DMB38_33845M2
2702-1;3,5-dihydroxyphenylglycine
from: 2702-1
OC(C(C1=CC(O)=CC(O)=C1)NC(C(C2=CC(O)=CC(O)=C2)N)=O)=O—
32702-3DMB38_33845M3
2702-2;Valine
from: 2702-2
OC(C(C(C)C)NC(C(C1=CC(O)=CC(O)=C1)NC(C(C2=CC(O)=CC(O)=C2)N)=O)=O)=O—
42702-4DMB38_33850M4
2702-3;Tryptophan
from: 2702-3
OC(C(CC1=CNC2=C1C=CC=C2)NC(C(C(C)C)NC(C(C3=CC(O)=CC(O)=C3)NC(C(C4=CC(O)=CC(O)=C4)N)=O)=O)=O)=O—
52702-5DMB38_33855M5
2702-4;3,5-dihydroxyphenylglycine
from: 2702-4
OC(C(C1=CC(O)=CC(O)=C1)NC(C(CC2=CNC3=C2C=CC=C3)NC(C(C(C)C)NC(C(C4=CC(O)=CC(O)=C4)NC(C(C5=CC(O)=CC(O)=C5)N)=O)=O)=O)=O)=O—
62702-6DMB38_33860M6
2702-5;4-hydroxyphenylglycine
from: 2702-5
OC(C(C1=CC(Cl)=C(O)C(Cl)=C1)NC(C(C2=CC(O)=CC(O)=C2)NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C(C)C)NC(C(C5=CC(O)=CC(O)=C5)NC(C(C6=CC(O)=CC(O)=C6)N)=O)=O)=O)=O)=O)=O—
72702-7DMB38_33860M7
2702-6;3,5-dihydroxyphenylglycine
from: 2702-6
OC(C(NC(C(C1=CC(Cl)=C(O)C(Cl)=C1)NC(C(C2=CC(O)=CC(O)=C2)NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C(C)C)NC(C(C5=CC(O)=CC(O)=C5)NC(C(C6=CC(O)=CC(O)=C6)N)=O)=O)=O)=O)=O)=O)C7=CC(O)=CC(O)=C7)=O—
82702-8DMB38_33860M8
2702-7;Tyrosine
from: 2702-7
OC(C(CC1=CC=C(O)C=C1)NC(C(NC(C(C2=CC(Cl)=C(O)C(Cl)=C2)NC(C(C3=CC(O)=CC(O)=C3)NC(C(CC4=CNC5=C4C=CC=C5)NC(C(C(C)C)NC(C(C6=CC(O)=CC(O)=C6)NC(C(C7=CC(O)=CC(O)=C7)N)=O)=O)=O)=O)=O)=O)C8=CC(O)=CC(O)=C8)=O)=O—
92702-9DMB38_33865M9
2702-8;3,5-dihydroxyphenylglycine
from: 2702-8
O=C(O)C(C1=CC(O)=CC(O)=C1)NC(C(CC2=CC=C(O)C=C2)NC(C(NC(C(C3=CC(Cl)=C(O)C(Cl)=C3)NC(C(C4=CC(O)=CC(O)=C4)NC(C(CC5=CNC6=C5C=CC=C6)NC(C(C(C)C)NC(C(C7=CC(O)=CC(O)=C7)NC(C(C8=CC(O)=CC(O)=C8)N)=O)=O)=O)=O)=O)=O)C9=CC(O)=CC(O)=C9)=O)=O—
102702DMB38_33865TE
2702-9
from: 2702-9
O=C(O)C(C1=CC(O)=CC(O)=C1)NC(C(CC2=CC=C3C=C2)NC(C(NC(C(C4=CC5=C(O)C(O3)=C4)NC(C(C6=CC(O)=CC(O)=C6)NC(C(CC7=CNC8=C7C=CC5=C8)NC(C(C(C)C)NC(C(C9=CC(O)=CC(O)=C9)NC(C(C%10=CC(O)=CC(O)=C%10)N)=O)=O)=O)=O)=O)=O)C%11=CC(O)=CC(O)=C%11)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture