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BGC0002696NRPS

Heterobactin B;Heterobactin S2

Producing organism
Rhodococcus erythropolis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Mycobacteriales›Nocardiaceae›Rhodococcus›Rhodococcus erythropolis group
Biosynthetic class
NRPS (Type I)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map11 genes · 22,526 bp

CAETgrCACATEAKR5 kb22.5 kb visible · 22,526 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Other
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

14 steps · 14 edges
Step 1
AWH04_05490, AWH04_0550…
+2,3-DHB
Step 6
Start
+L-ornithine
Step 2
AWH04_05495
Step 7
?
Step 3
AWH04_05505, ?
Step 4
AWH04_05480
+Arginine
Step 10
AWH04_05480
+Arginine
Step 5
AWH04_05480
+Glycine
Step 11
AWH04_05480
+Glycine
Step 8
AWH04_05480
Step 12
AWH04_05480
Step 9TE
AWH04_05480
Step 13TE
AWH04_05480
Step 14
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12696-1AWH04_05490, AWH04_05500, AWH04_05510—
2,3-DHB
OC1=CC=CC(C(O)=O)=C1O—
22696-2AWH04_05495—
2696-1
from: 2696-1
OC1=CC=CC(C(O[R])=O)=C1O—
32696-3AWH04_05505, ?—
2696-2
from: 2696-2
OC1=CC=CC(C(O)=O)=C1O—
42696-4AWH04_05480—
2696-3;Arginine
from: 2696-3
O=C(C(C=CC=C1O)=C1O)/N=C(N)/NCCC[C@H](N)C(O)=O—
52696-5AWH04_05480—
2696-4;Glycine
from: 2696-4
O=C([C@@H](CCCN/C(N)=N/C(C1=C(O)C(O)=CC=C1)=O)N)NCC(O)=O—
62696-6Start—
L-ornithine
O=C([C@H](CCCN)N)O—
72696-7?—
2696-6
from: 2696-6
O=C([C@H](CCCNO)N)O—
82696-8AWH04_05480—
2696-5;2696-7
from: 2696-5, 2696-7
O=C([C@@H](CCCN/C(N)=N/C(C1=C(O)C(O)=CC=C1)=O)N)NCC(N[C@@H](CCCNO)C(O)=O)=O—
92696(1)AWH04_05480TE
2696-8
from: 2696-8
O=C([C@@H](CCCN/C(N)=N/C(C1=C(O)C(O)=CC=C1)=O)N)NCC(NC2CCCN(O)C2=O)=O—
102696-9AWH04_05480—
2696-3;2696-3;Arginine
from: 2696-3, 2696-3
O=C(C(C=CC=C1O)=C1O)/N=C(N)/NCCC[C@H](NC(C2=CC=CC(O)=C2O)=O)C(O)=O—
112696-10AWH04_05480—
2696-9;Glycine
from: 2696-9
OC1=C(C=CC=C1C(N[C@H](CCCN/C(N)=N/C(C2=C(O)C(O)=CC=C2)=O)C(NCC(O)=O)=O)=O)O—
122696-11AWH04_05480—
2696-10;2696-7
from: 2696-10, 2696-7
OC1=C(C=CC=C1C(N[C@H](CCCN/C(N)=N/C(C2=C(O)C(O)=CC=C2)=O)C(NCC(N[C@@H](CCCNO)C(O)=O)=O)=O)=O)O—
132696-12AWH04_05480TE
2696-11
from: 2696-11
O=C1N(O)CCC[C@@H]1NC(CNC([C@H](NC(C2=CC=CC(O)=C2O)=O)CCCN/C(N)=N/C(C(C=CC=C3O)=C3O)=O)=O)=O—
142696(2)?—
2696-12
from: 2696-12
O=C1N(O)CCC[C@@H]1NC(CNC([C@H](NC(C2=CC=C(S(=O)(O)=O)C(O)=C2O)=O)CCCN/C(N)=N/C(C(C=CC=C3O)=C3O)=O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture