NPdia
← Back to Repository
BGC0002686NRPS

Madurastatin D1;Madurastatin D2;(-)-Madurastatin C1

Producing organism
Actinomadura sp. WMMA1423
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinomadura
Biosynthetic class
NRPS (Type I)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map81 genes · 113,663 bp

20 kb113.7 kb visible · 113,663 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CyHeterocyclization (Cy)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

17 steps · 17 edges
Step 1
Start
+Chorismate
Step 6
Start
+L-Asparate
Step 9
Start
+L-Orninthine
Step 2
FKD65_RS04335
Step 7
FKD65_RS04505
Step 10
FKD65_RS04320
Step 3Load
FKD65_RS04500;FKD65_RS0…
Step 4M1
FKD65_RS04515
+Serine
Step 5M2
FKD65_RS04330
+Glycine
Step 8M3
FKD65_RS04330
Step 11M4
FKD65_RS04330
Step 12M5
FKD65_RS04330
Step 13
?
Step 14
?
Step 15
?
Step 16
?
Step 17
FKD65_RS04240
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12686-1Start—
Chorismate
O=C([O-])C1=C[C@@H](OC(C([O-])=O)=C)[C@H](O)C=C1—
22686-2FKD65_RS04335—
2686-1
from: 2686-1
O=C([O-])C1=C(O)C=CC=C1—
32686-3FKD65_RS04500;FKD65_RS04515Loading
2686-2
from: 2686-2
O=C(O)C1=C(O)C=CC=C1—
42686-4FKD65_RS04515M1
2686-3;Serine
from: 2686-3
OC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O—
52686-5FKD65_RS04330M2
2686-4;Glycine
from: 2686-4
OC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O—
62686-6Start—
L-Asparate
N[C@H](C(O)=O)CC(O)=O—
72686-7FKD65_RS04505—
2686-6
from: 2686-6
NCCC(O)=O—
82686-8FKD65_RS04330M3
2686-5;2686-7
from: 2686-5, 2686-7
OC(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O—
92686-9Start—
L-Orninthine
NCCCC(N)C(O)=O—
102686-10FKD65_RS04320—
2686-9
from: 2686-9
OC(C(N)CCCNO)=O—
112686-11FKD65_RS04330M4
2686-8;2686-10
from: 2686-8, 2686-10
OC([C@H](N([R])C)CCCN(O)C(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O)=O—
122686-12FKD65_RS04330M5
2686-11;2686-10
from: 2686-11, 2686-10
O=C([C@@H](CCCNO)NC([C@H](N([R])C)CCCN(O)C(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O)=O)O—
132686-13?—
2686-12
from: 2686-12
CN([R])[C@H](CCCN(O)C(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O)C(N[C@@H]3CCCN(O)C3=O)=O—
142686(1)?—
2686-12
from: 2686-12
CN[C@H](CCCN(O)C(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O)C(N[C@@H]3CCCN(O)C3=O)=O—
152686-14?—
2686-12
from: 2686-12
CN(C)[C@H](CCCN(O)C(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O)C(N[C@@H]3CCCN(O)C3=O)=O—
162686(2)?—
2686-14
from: 2686-14
ON(C(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O)CCC[C@@H]3C(N([C@@H]4CCCN(O)C4=O)[C@]([H])(C)N3C)=O—
172686(3)FKD65_RS04240—
2686-14
from: 2686-14
ON(C(CCNC(CNC([C@H]1N=C(C2=C(O)C=CC=C2)OC1)=O)=O)=O)CCC[C@@H]3C(N([C@@H]4CCCN(O)C4=O)C(C)(C)N3C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture