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BGC0002676NRPS

Skyllamycin D;Skyllamycin E

Producing organism
Streptomyces anulatus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map76 genes · 124,179 bp

20 kb124.2 kb visible · 124,179 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
CyHeterocyclization (Cy)
A-OXAdenylation-oxidase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1
Start
Step 3
Start
Step 5
?
Step 2
KZO11_19465;KZO11_19470
Step 4
KZO11_19485
Step 6M1
KZO11_19525
+Threonine
Step 7M2
KZO11_19525
+Alanine
Step 8M3
KZO11_19525
Step 9M4
KZO11_19525
+Glycine
Step 10M5
KZO11_19520
+β-OH-Phenylalanine
Step 11M6
KZO11_19520
+Proline
Step 12M7
KZO11_19520
Step 13M8
KZO11_19520
+Tryptophan
Step 14M9
KZO11_19515
+α-OH-Glycine
Step 15M10
KZO11_19515
+Leucine
Step 16M11
KZO11_19515
+β-OH-Leucine
Step 17TE
KZO11_19515
Step 18TE
KZO11_19515
Step 19TE
KZO11_19515
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12676-1Start—
OC(CC[C@@H](C(O)=O)N)=O—
22676-2KZO11_19465;KZO11_19470—
2676-1
from: 2676-1
N[C@H](C(O)=O)[C@H](C)C(O)=O—
32676-3Start—
OC1=CC=C(C[C@H](N)C(O)=O)C=C1—
42676-4KZO11_19485—
2676-3
from: 2676-3
N[C@H](C(O)=O)CC1=CC=C(OC)C=C1—
52676-5?—
C/C=C\C1=C(C([R])CC(O)=O)C=CC=C1—
62676-6KZO11_19525M1
2676-5;Threonine
from: 2676-5
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(O)=O)=O)C=CC=C1—
72676-7KZO11_19525M2
2676-6;Alanine
from: 2676-6
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(O)=O)=O)=O)C=CC=C1—
82676-8KZO11_19525M3
2676-7;2676-2
from: 2676-7, 2676-2
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(O)=O)=O)=O)=O)C=CC=C1—
92676-9KZO11_19525M4
2676-8;Glycine
from: 2676-8
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(O)=O)=O)=O)=O)=O)C=CC=C1—
102676-10KZO11_19520M5
2676-9;β-OH-Phenylalanine
from: 2676-9
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(N[C@@H]([C@H](C2=CC=CC=C2)O)C(O)=O)=O)=O)=O)=O)=O)C=CC=C1—
112676-11KZO11_19520M6
2676-10;Proline
from: 2676-10
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(N[C@@H]([C@H](C2=CC=CC=C2)O)C(N3[C@H](C(O)=O)CCC3)=O)=O)=O)=O)=O)=O)C=CC=C1—
122676-12KZO11_19520M7
2676-11;2676-4
from: 2676-11, 2676-4
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(N[C@@H]([C@H](C2=CC=CC=C2)O)C(N3[C@H](C(N[C@H](C(O)=O)[C@@H](O)C4=CC=C(OC)C=C4)=O)CCC3)=O)=O)=O)=O)=O)=O)C=CC=C1—
132676-13KZO11_19520M8
2676-12;Tryptophan
from: 2676-12
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(N[C@@H]([C@H](C2=CC=CC=C2)O)C(N3[C@H](C(N[C@H](C(N[C@H](CC4=CNC5=C4C=CC=C5)C(O)=O)=O)[C@@H](O)C6=CC=C(OC)C=C6)=O)CCC3)=O)=O)=O)=O)=O)=O)C=CC=C1—
142676-14KZO11_19515M9
2676-13;α-OH-Glycine
from: 2676-13
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(N[C@@H]([C@H](C2=CC=CC=C2)O)C(N3[C@H](C(N[C@H](C(N[C@H](CC4=CNC5=C4C=CC=C5)C(NCC(O)=O)=O)=O)[C@@H](O)C6=CC=C(OC)C=C6)=O)CCC3)=O)=O)=O)=O)=O)=O)C=CC=C1—
152676-15KZO11_19515M10
2676-14;Leucine
from: 2676-14
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(N[C@@H]([C@H](C2=CC=CC=C2)O)C(N3[C@H](C(N[C@H](C(N[C@H](CC4=CNC5=C4C=CC=C5)C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)[C@@H](O)C6=CC=C(OC)C=C6)=O)CCC3)=O)=O)=O)=O)=O)=O)C=CC=C1—
162676-16KZO11_19515M11
2676-15;β-OH-Leucine
from: 2676-15
C/C=C\C1=C(C([R])CC(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H]([C@H](C)C(O)=O)C(NCC(N[C@@H]([C@H](C2=CC=CC=C2)O)C(N3[C@H](C(N[C@H](C(N[C@H](CC4=CNC5=C4C=CC=C5)C(NCC(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)[C@@H](O)C6=CC=C(OC)C=C6)=O)CCC3)=O)=O)=O)=O)=O)=O)C=CC=C1—
172676-17KZO11_19515TE
2676-16
from: 2676-16
C/C=C\C1=C(C([R])CC(NC(C(NC(C(NC(C(C(O)=O)C)C2=O)=O)C)=O)C(C)OC(C(C(O)C(C)C)NC(C(CC(C)C)NC(C(NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C(C5=CC=C(OC)C=C5)O)NC(C6N(C(C(C(O)C7=CC=CC=C7)NC(CN2)=O)=O)CCC6)=O)=O)=O)O)=O)=O)=O)=O)C=CC=C1—
182676(1)KZO11_19515TE
2676-16
from: 2676-16
C/C=C\C1=C(C(O)CC(NC(C(NC(C(NC(C(C(O)=O)C)C2=O)=O)C)=O)C(C)OC(C(C(O)C(C)C)NC(C(CC(C)C)NC(C(NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C(C5=CC=C(OC)C=C5)O)NC(C6N(C(C(C(O)C7=CC=CC=C7)NC(CN2)=O)=O)CCC6)=O)=O)=O)O)=O)=O)=O)=O)C=CC=C1—
192676(2)KZO11_19515TE
2676-16
from: 2676-16
C/C=C\C1=C(CCC(NC(C(NC(C(NC(C(C(O)=O)C)C2=O)=O)C)=O)C(C)OC(C(C(O)C(C)C)NC(C(CC(C)C)NC(C(NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C(C5=CC=C(OC)C=C5)O)NC(C6N(C(C(C(O)C7=CC=CC=C7)NC(CN2)=O)=O)CCC6)=O)=O)=O)O)=O)=O)=O)=O)C=CC=C1—
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