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BGC0002671PKS

Kendomycin B

Producing organism
Verrucosispora sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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kendomycin B

Gene Cluster Map33 genes · 79,937 bp

KSKSKSKSKSCALKSKSKS20 kb79.9 kb visible · 79,937 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ECHEnoyl-CoA hydratase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
kmy18
+Malonyl-CoA, Malonyl-CoA
Step 2
kmy18
Step 3
kmy17, kmy29
Step 4
kmy16
Step 5
kmy15
Step 6
kmy14
Step 7Load
kmy19, ?
Inactive: KR
Step 8M1
kmy19
Step 9M2
kmy19
Inactive: DH
Step 10M3
kmy20
Step 11M4
kmy10
Step 12M5
kmy10
Step 13M6
kmy11
Step 14M7
kmy12
Step 15M8
kmy12
Step 16TE
kmy12, (kmy5, kmy9, kmy…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12671-1kmy18—
Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
O=C(CC(CC(CC(CC([R])=O)=O)=O)=O)O—
22671-2kmy18—
2671-1
from: 2671-1
O=C(CC(C1)=O)C=C1CC([R])=O—
32671-3kmy17, kmy29—
2671-2
from: 2671-2
OC1=CC(O)=CC(CC([R])=O)=C1—
42671-4kmy16—
2671-3
from: 2671-3
OC1=CC(O)=CC(C(C([O-])=O)=O)=C1—
52671-5kmy15—
2671-4
from: 2671-4
OC1=CC(O)=CC(C([H])=O)=C1—
62671-6kmy14—
2671-5
from: 2671-5
OC1=CC(O)=CC(C(O)=O)=C1—
72671-7kmy19, ?Loading
2671-6
from: 2671-6
OC1=CC(O)=CC(C(O)=O)=C1{'Inactive': ['KR']}
82671-8kmy19M1
2671-7
from: 2671-7
OC1=CC(O)=CC(/C=C(C(O)=O)\C)=C1—
92671-9kmy19M2
2671-8
from: 2671-8
OC1=CC(O)=CC(/C=C([C@@H](O)[C@H](C(O)=O)C)\C)=C1{'Inactive': ['DH']}
102671-10kmy20M3
2671-9
from: 2671-9
OC1=CC(O)=CC(/C=C([C@@H](O)[C@H]([C@H](O)CC(O)=O)C)\C)=C1—
112671-11kmy10M4
2671-10
from: 2671-10
OC1=CC(O)=CC(/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](C(O)=O)C)C)\C)=C1—
122671-12kmy10M5
2671-11
from: 2671-11
OC1=CC(O)=CC(/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C(O)=O)\C)C)C)\C)=C1—
132671-13kmy11M6
2671-12
from: 2671-12
OC1=CC(O)=CC(/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C[C@H](C(O)=O)C)\C)C)C)\C)=C1—
142671-14kmy12M7
2671-13
from: 2671-13
OC1=CC(O)=CC(/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C[C@H](C[C@@H](C(O)=O)C)C)\C)C)C)\C)=C1—
152671-15kmy12M8
2671-14
from: 2671-14
OC1=CC(O)=CC(/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C[C@H](C[C@@H](C(CC(O)=O)=O)C)C)\C)C)C)\C)=C1—
162671kmy12, (kmy5, kmy9, kmy13?)TE
2671-15
from: 2671-15
C/C(C[C@@H](C)C[C@H](C)[C@@](O1)(O)C=C2C1=CC(C(O)=C32)=O)=C\[C@@H](C)CC[C@H]4O[C@@H]3[C@H](C)[C@@H](O)[C@H]4C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture