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BGC0002649Hybrid

Nocamycin V

Producing organism
Amycolatopsis sp. EV170708-02-1
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
18
DOI
MIBiG entry
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nocamycin V

Gene Cluster Map24 genes · 62,259 bp

AKSKSKSKSKS10 kb62.3 kb visible · 62,259 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
MJQ72_01080
+Malonyl-CoA
Step 2
MJQ72_01080
+Methylmalonyl-CoA
Step 3
MJQ72_01080
+Methylmalonyl-CoA
Step 4
MJQ72_01080;MJQ72_01075
+Malonyl-CoA
Step 5
MJQ72_01070
+Methylmalonyl-CoA
Inactive: DH
Step 6
MJQ72_01065
+Methylmalonyl-CoA
Step 7
MJQ72_01060
+Methylmalonyl-CoA
Step 8
MJQ72_01055
+Malonyl-CoA
Step 9
MJQ72_01055
+Malonyl-CoA
Step 10
MJQ72_00970
+Glycine
Step 11
MJQ72_01010
Step 12
MJQ72_01050
Step 13
MJQ72_01000
Step 14
MJQ72_01020?/MJQ72_0097…
Step 15
MJQ72_01015
Step 16
MJQ72_01020?/MJQ72_0097…
Step 17
MJQ72_01085
Step 18
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12649-1MJQ72_01080—
Malonyl-CoA
O=C(C)O—
22649-2MJQ72_01080—
2649-1;Methylmalonyl-CoA
from: 2649-1
OC(C(C)C(O)C)=O—
32649-3MJQ72_01080—
2649-2;Methylmalonyl-CoA
from: 2649-2
OC(C(C)C([C@@H](C(O)=O)C)=O)C—
42649-4MJQ72_01080;MJQ72_01075—
2649-3;Malonyl-CoA
from: 2649-3
OC(C(C)C([C@@H]([C@H](CC(O)=O)O)C)=O)C—
52649-5MJQ72_01070—
2649-4;Methylmalonyl-CoA
from: 2649-4
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H](C(O)=O)C)O)C)=O)C{'Inactive': ['DH']}
62649-6MJQ72_01065—
2649-5;Methylmalonyl-CoA
from: 2649-5
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(C(O)=O)C)C)O)C)=O)C—
72649-7MJQ72_01060—
2649-6;Methylmalonyl-CoA
from: 2649-6
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C(O)=O)C)C)O)C)=O)C—
82649-8MJQ72_01055—
2649-7;Malonyl-CoA
from: 2649-7
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C=C/C(O)=O)C)C)O)C)=O)C—
92649-9MJQ72_01055—
2649-8;Malonyl-CoA
from: 2649-8
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C=C/C(CC(O)=O)=O)C)C)O)C)=O)C—
102649-10MJQ72_00970—
2649-9;Glycine
from: 2649-9
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C=C/C(CC(NCC(O)=O)=O)=O)C)C)O)C)=O)C—
112649-11MJQ72_01010—
2649-10
from: 2649-10
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C)[C@H](O)C)([C@@H]([C@@H](O)C3)C)O2)C—
122649-12MJQ72_01050—
2649-11
from: 2649-11
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C)[C@H](O)C)(C(C)=CC3)O2)C—
132649-13MJQ72_01000—
2649-12
from: 2649-12
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C)[C@H](O4)C)([C@@]4(CC3)C)O2)C—
142649-14MJQ72_01020?/MJQ72_00975?—
2649-13
from: 2649-13
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(O)=O)[C@H](O4)C)([C@@]4(CC3)C)O2)C—
152649-15MJQ72_01015—
2649-14
from: 2649-14
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(OC)=O)[C@H](O4)C)([C@@]4(CC3)C)O2)C—
162649-16MJQ72_01020?/MJQ72_00975?—
2649-15
from: 2649-15
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(OC)=O)[C@H](O4)C)([C@@]4(C[C@H]3O)C)O2)C—
172649-17MJQ72_01085—
2649-16
from: 2649-16
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(OC)=O)[C@H](O4)C)([C@@]4(CC3=O)C)O2)C—
182649?—
2649-17
from: 2649-17
CC(/C=C/C(C1=C(O)CNC1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(OC)=O)[C@H](O4)C)([C@@]4(CC3=O)CO)O2)C—
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