NPdia
← Back to Repository
BGC0002638NRPS

Misaugamycin A;Misaugamycin B

Producing organism
Streptomyces sp. WAC 00631
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map38 genes · 73,156 bp

AAAAAAAA10 kb73.2 kb visible · 73,156 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
AmTAminotransferase I/II
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1
Start
Step 2M1
DMH02_027360, (DMH02_02…
+4-hydroxyphenylgl…
Step 3M2
DMH02_027325;DMH02_0273…
+Tryptophan
Step 4M3
DMH02_027360, DMH02_027…
+4-hydroxyphenylgl…
Step 5M4
DMH02_027340
+4-hydroxyphenylgl…
Step 6M5
DMH02_027360, DMH02_027…
+4-hydroxyphenylgl…
Step 7M6
DMH02_027340
+Tyrosine
Step 8M7
DMH02_027360, DMH02_027…
+4-hydroxyphenylgl…
Step 9TE
DMH02_027345, (DMH02_02…
Step 10TE
DMH02_027345, (DMH02_02…
Step 11TE
DMH02_027345, (DMH02_02…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12638-1Start—
OC(C[R])=O—
22638-2DMH02_027360, (DMH02_027320;DMH02_027325)M1
2638-1;4-hydroxyphenylglycine
from: 2638-1
OC(C(C1=CC=C(O)C(Cl)=C1)NC(C[R])=O)=O—
32638-3DMH02_027325;DMH02_027330M2
2638-2;Tryptophan
from: 2638-2
OC(C(CC1=CNC2=C1C=CC=C2)NC(C(C3=CC=C(O)C(Cl)=C3)NC(C[R])=O)=O)=O—
42638-4DMH02_027360, DMH02_027335M3
2638-3;4-hydroxyphenylglycine
from: 2638-3
OC(C(NC(C(CC1=CNC2=C1C=CC=C2)NC(C(C3=CC=C(O)C(Cl)=C3)NC(C[R])=O)=O)=O)C4=CC=C(O)C(Cl)=C4)=O—
52638-5DMH02_027340M4
2638-4;4-hydroxyphenylglycine
from: 2638-4
OC(C(C1=CC=C(O)C=C1)NC(C(NC(C(CC2=CNC3=C2C=CC=C3)NC(C(C4=CC=C(O)C(Cl)=C4)NC(C[R])=O)=O)=O)C5=CC=C(O)C(Cl)=C5)=O)=O—
62638-6DMH02_027360, DMH02_027340M5
2638-5;4-hydroxyphenylglycine
from: 2638-5
OC(C(C1=CC=C(O)C(Cl)=C1)NC(C(C2=CC=C(O)C=C2)NC(C(NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C5=CC=C(O)C(Cl)=C5)NC(C[R])=O)=O)=O)C6=CC=C(O)C(Cl)=C6)=O)=O)=O—
72638-7DMH02_027340M6
2638-6;Tyrosine
from: 2638-6
OC(C(CC1=CC=C(O)C=C1)NC(C(C2=CC=C(O)C(Cl)=C2)NC(C(C3=CC=C(O)C=C3)NC(C(NC(C(CC4=CNC5=C4C=CC=C5)NC(C(C6=CC=C(O)C(Cl)=C6)NC(C[R])=O)=O)=O)C7=CC=C(O)C(Cl)=C7)=O)=O)=O)=O—
82638-8DMH02_027360, DMH02_027345M7
2638-7;4-hydroxyphenylglycine
from: 2638-7
O=C(O)C(C1=CC=C(O)C=C1)NC(C(CC2=CC=C(O)C=C2)NC(C(C3=CC=C(O)C(Cl)=C3)NC(C(C4=CC=C(O)C=C4)NC(C(NC(C(CC5=CNC6=C5C=CC=C6)NC(C(C7=CC=C(O)C(Cl)=C7)NC(C[R])=O)=O)=O)C8=CC=C(O)C(Cl)=C8)=O)=O)=O)=O—
92638-9DMH02_027345, (DMH02_027365, DMH02_027370)TE
2638-8
from: 2638-8
O=C(O)C(C1=CC=C(O)C=C1)NC(C(CC2=CC=C(OC3C4=O)C=C2)NC(C(C5=CC=C(O)C(Cl)=C5)NC(C(C6(C=C4)C3)NC(C(NC(C(CC7=CN6C8=C7C=CC=C8)NC(C(C9=CC=C(O)C(Cl)=C9)NC(C[R])=O)=O)=O)C%10=CC=C(O)C(Cl)=C%10)=O)=O)=O)=O—
102638(1)DMH02_027345, (DMH02_027365, DMH02_027370)TE
2638-8
from: 2638-8
O=C(O)C(C1=CC=C(O)C=C1)NC(C(CC2=CC=C(OC3C4=O)C=C2)NC(C(C5=CC=C(O)C(Cl)=C5)NC(C(C6(C=C4)C3)NC(C(NC(C(CC7=CN6C8=C7C=CC=C8)NC(C(C9=CC=C(O)C(Cl)=C9)NC(CC(O)=O)=O)=O)=O)C%10=CC=C(O)C(Cl)=C%10)=O)=O)=O)=O—
112638(2)DMH02_027345, (DMH02_027365, DMH02_027370)TE
2638-8
from: 2638-8
O=C(O)C(C1=CC=C(O)C=C1)NC(C(CC2=CC=C(OC3C4=O)C=C2)NC(C(C5=CC=C(O)C(Cl)=C5)NC(C(C6(C=C4)C3)NC(C(NC(C(CC7=CN6C8=C7C=CC=C8)NC(C(C9=CC=C(O)C(Cl)=C9)NC(CS(O)(=O)=O)=O)=O)=O)C%10=CC=C(O)C(Cl)=C%10)=O)=O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture