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BGC0002637NRPS

Rimomycin A;Rimomycin B;Rimomycin C

Producing organism
Streptomyces sp. WAC 06783
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map29 genes · 75,560 bp

AAAAAAAA20 kb75.6 kb visible · 75,560 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
AmTAminotransferase I/II
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1M1
DMH18_08095
+4-hydroxyphenylgl…
Step 2M2
DMH18_08095
Step 3M3
DMH18_08090, DMH18_0806…
Step 4M4
DMH18_08085
Step 5M5
DMH18_08085, DMH18_0806…
Step 6M6
DMH18_08085
Step 7M7
DMH18_08080
Step 8TE
DMH18_08080, (DMH18_080…
Step 9TE
DMH18_08080, (DMH18_080…
Step 10TE
DMH18_08080, (DMH18_080…
Step 11TE
DMH18_08080, (DMH18_080…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12637-1DMH18_08095M1
4-hydroxyphenylglycine
OC(C(C1=CC=C(O)C=C1)N)=O—
22637-2DMH18_08095M2
2637-1
from: 2637-1
OC(C(CC1=CNC2=C1C=CC=C2)NC(C(C3=CC=C(O)C=C3)N)=O)=O—
32637-3DMH18_08090, DMH18_08065?M3
2637-2
from: 2637-2
OC(C(NC(C(CC1=CNC2=C1C=CC=C2)NC(C(C3=CC=C(O)C=C3)N)=O)=O)C4=CC=C(O)C([R1])=C4)=O—
42637-4DMH18_08085M4
2637-3
from: 2637-3
OC(C(C1=CC=C(O)C=C1)NC(C(NC(C(CC2=CNC3=C2C=CC=C3)NC(C(C4=CC=C(O)C=C4)N)=O)=O)C5=CC=C(O)C([R1])=C5)=O)=O—
52637-5DMH18_08085, DMH18_08065?M5
2637-4
from: 2637-4
OC(C(C1=CC=C(O)C([R2])=C1)NC(C(C2=CC=C(O)C=C2)NC(C(NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C5=CC=C(O)C=C5)N)=O)=O)C6=CC=C(O)C([R1])=C6)=O)=O)=O—
62637-6DMH18_08085M6
2637-5
from: 2637-5
OC(C(CC1=CC=C(O)C=C1)N(C)C(C(C2=CC=C(O)C([R2])=C2)NC(C(C3=CC=C(O)C=C3)NC(C(NC(C(CC4=CNC5=C4C=CC=C5)NC(C(C6=CC=C(O)C=C6)N)=O)=O)C7=CC=C(O)C([R1])=C7)=O)=O)=O)=O—
72637-7DMH18_08080M7
2637-6
from: 2637-6
O=C(O)C(C1=CC=C(O)C=C1)NC(C(CC2=CC=C(O)C=C2)N(C)C(C(C3=CC=C(O)C([R2])=C3)NC(C(C4=CC=C(O)C=C4)NC(C(NC(C(CC5=CNC6=C5C=CC=C6)NC(C(C7=CC=C(O)C=C7)N)=O)=O)C8=CC=C(O)C([R1])=C8)=O)=O)=O)=O—
82637-8DMH18_08080, (DMH18_08060, DMH18_08055)TE
2637-7
from: 2637-7
O=C(C(C1=CC=C2C([R2])=C1)NC(C3NC(C(NC(C(CC4=CNC5=C4C=CC6=C5)NC(C(C7=CC=C(O)C=C7)N)=O)=O)C8=CC=C(O)C([R1])=C8)=O)=O)N(C)C(CC9=CC=C(OC%10=CC3=CC6=C%10O)C=C9)C(NC(C%11=CC=C(O)C(O2)=C%11)C(O)=O)=O—
92637(1)DMH18_08080, (DMH18_08060, DMH18_08055)TE
2637-7
from: 2637-7
O=C(C(C1=CC=C2C=C1)NC(C3NC(C(NC(C(CC4=CNC5=C4C=CC6=C5)NC(C(C7=CC=C(O)C=C7)N)=O)=O)C8=CC=C(O)C=C8)=O)=O)N(C)C(CC9=CC=C(OC%10=CC3=CC6=C%10O)C=C9)C(NC(C%11=CC=C(O)C(O2)=C%11)C(O)=O)=O—
102637(2)DMH18_08080, (DMH18_08060, DMH18_08055)TE
2637-7
from: 2637-7
O=C(C(C1=CC=C2C(Cl)=C1)NC(C3NC(C(NC(C(CC4=CNC5=C4C=CC6=C5)NC(C(C7=CC=C(O)C=C7)N)=O)=O)C8=CC=C(O)C=C8)=O)=O)N(C)C(CC9=CC=C(OC%10=CC3=CC6=C%10O)C=C9)C(NC(C%11=CC=C(O)C(O2)=C%11)C(O)=O)=O—
112637(3)DMH18_08080, (DMH18_08060, DMH18_08055)TE
2637-7
from: 2637-7
O=C(C(C1=CC=C2C(Cl)=C1)NC(C3NC(C(NC(C(CC4=CNC5=C4C=CC6=C5)NC(C(C7=CC=C(O)C=C7)N)=O)=O)C8=CC=C(O)C(Cl)=C8)=O)=O)N(C)C(CC9=CC=C(OC%10=CC3=CC6=C%10O)C=C9)C(NC(C%11=CC=C(O)C(O2)=C%11)C(O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture