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BGC0002581NRPS

Bosamycin A;Bosamycin B;Bosamycin C;Bosamycin D;Bosamycin E;Bosamycin F

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map9 genes · 37,067 bp

CACAECACACATauDCAECACATEA5 kb37.1 kb visible · 37,067 bp total
Biosynthetic (core)
Biosynthetic (additional)
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1M1
QKF54435.2
+Tyrosine
Step 8
QKF54440.2
+Tyrosine
Step 2
QKF54434.1
+(Carbamic acid/Im…
Step 9
QKF54440.2
Step 3M2
QKF54435.2
+Tyrosine
Step 10
QKF54441.1
Step 4M3
QKF54436.1
+Leucine
Step 11
QKF54442.2
Step 5M4
QKF54436.1
+Aspartic acid
Step 6
QKF54437.1
Step 7M5
QKF54436.1
+Serine
Step 12M6
QKF54438.1
Step 13M7
QKF54438.1
+Leucine
Step 14M8
QKF54438.1
+Glycine
Step 15TE
QKF54438.1
Step 16TE
QKF54438.1
Step 17TE
QKF54438.1
Step 18TE
QKF54438.1
Step 19TE
QKF54438.1
Step 20TE
QKF54438.1
Step 21TE
QKF54438.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12581-1QKF54435.2M1
Tyrosine
OC([C@@H](N)CC1=CC=C(O)C=C1)=O—
22581-2QKF54434.1—
2581-1;(Carbamic acid/Imidodicarboxylic acid)
from: 2581-1
OC([C@@H](N[R1])CC1=CC=C(O)C=C1)=O—
32581-3QKF54435.2M2
2581-2;Tyrosine
from: 2581-2
OC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](N[R1])CC2=CC=C(O)C=C2)=O)=O—
42581-4QKF54436.1M3
2581-3;Leucine
from: 2581-3
OC([C@@H](CC(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](N[R1])CC2=CC=C(O)C=C2)=O)=O)=O—
52581-5QKF54436.1M4
2581-4;Aspartic acid
from: 2581-4
OC([C@@H](CC(O)=O)NC([C@@H](CC(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](N[R1])CC2=CC=C(O)C=C2)=O)=O)=O)=O—
62581-6QKF54437.1—
2581-5
from: 2581-5
OC([C@@H]([C@H](O)C(O)=O)NC([C@@H](CC(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](N[R1])CC2=CC=C(O)C=C2)=O)=O)=O)=O—
72581-7QKF54436.1M5
2581-6;Serine
from: 2581-6
OC([C@@H](CO)NC([C@@H]([C@H](O)C(O)=O)NC([C@@H](CC(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](N[R1])CC2=CC=C(O)C=C2)=O)=O)=O)=O)=O—
82581-8QKF54440.2—
Tyrosine
OC([C@H](CC1=CC=C(O)C=C1)N)=O—
92581-9QKF54440.2—
2581-8
from: 2581-8
OC([C@H](CC1=C(O)C=C(O)C=C1)N)=O—
102581-10QKF54441.1—
2581-9
from: 2581-9
OC([C@H](CC1=C(O)C=C(O)C=C1)N)=O—
112581-11QKF54442.2—
2581-10
from: 2581-10
OC([C@H](CC1=C(OC)C=C(O)C=C1)N)=O—
122581-12QKF54438.1M6
2581-7;2581-11
from: 2581-7, 2581-11
OC([C@H](CC1=C(OC)C=C(O)C=C1)NC([C@@H](CO)NC([C@@H]([C@H](O)C(O)=O)NC([C@@H](CC(C)C)NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](N[R1])CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O—
132581-13QKF54438.1M7
2581-12;Leucine
from: 2581-12
OC([C@@H](CC(C)C)NC([C@H](CC1=C(OC)C=C(O)C=C1)NC([C@@H](CO)NC([C@@H]([C@H](O)C(O)=O)NC([C@@H](CC(C)C)NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](N[R1])CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O)=O—
142581-14QKF54438.1M8
2581-13;Glycine
from: 2581-13
O=C(CNC([C@@H](CC(C)C)NC([C@H](CC1=C(OC)C=C(O)C=C1)NC([C@@H](CO)NC([C@@H]([C@H](O)C(O)=O)NC([C@@H](CC(C)C)NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](N[R1])CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O)=O)O—
152581-15QKF54438.1TE
2581-14
from: 2581-14
OC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC(O)=O)=O)CC(C)C)=O)CC(C=CC(O)=C2)=C2OC)=O)CO)=O)[C@H](C(O)=O)O)=O)CC(C)C)=O)N)C=C1—
162581-16QKF54438.1TE
2581-14
from: 2581-14
OC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC([R2])=O)=O)CC(C)C)=O)CC(C=CC(O)=C2)=C2OC)=O)CO)=O)[C@H](C(O)=O)O)=O)CC(C)C)=O)NC([C@H](CC3=CC=C(O)C=C3)N[R1])=O)C=C1—
172581-17QKF54438.1TE
2581-14
from: 2581-14
OC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC(O)=O)=O)CC(C)C)=O)CC(C=CC(O)=C2)=C2OC)=O)CO)=O)[C@H](C(O)=O)O)=O)CC(C)C)=O)NC([C@H](CC3=CC=C(O)C=C3)NC(N)=O)=O)C=C1—
182581-18QKF54438.1TE
2581-14
from: 2581-14
OC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC(O)=O)=O)CC(C)C)=O)CC(C=CC(O)=C2)=C2OC)=O)CO)=O)[C@H](C(O)=O)O)=O)CC(C)C)=O)NC([C@H](CC3=CC=C(O)C=C3)NC(NC(O)=O)=O)=O)C=C1—
192581-19QKF54438.1TE
2581-14
from: 2581-14
OC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC(O)=O)=O)CC(C)C)=O)CC(C=CC(O)=C2)=C2OC)=O)CO)=O)[C@H](C(O)=O)O)=O)CC(C)C)=O)NC([C@H](CC3=CC=C(O)C=C3)NC(C)=O)=O)C=C1—
202581-20QKF54438.1TE
2581-14
from: 2581-14
OC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC(OC)=O)=O)CC(C)C)=O)CC(C=CC(O)=C2)=C2OC)=O)CO)=O)[C@H](C(O)=O)O)=O)CC(C)C)=O)NC([C@H](CC3=CC=C(O)C=C3)NC(NC(O)=O)=O)=O)C=C1—
212581-21QKF54438.1TE
2581-14
from: 2581-14
OC1=CC=C(C[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC(OC)=O)=O)CC(C)C)=O)CC(C=CC(O)=C2)=C2OC)=O)CO)=O)[C@H](C(O)=O)O)=O)CC(C)C)=O)NC([C@H](CC3=CC=C(O)C=C3)NC(C)=O)=O)C=C1—
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