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BGC0002559PKS

Lenoremycin

Producing organism
Streptomyces hygroscopicus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces violaceusniger group
Biosynthetic class
PKS (Unknown)
Total steps
28
DOI
MIBiG entry
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lenoremycin
C47H78O13850.54 Da

Gene Cluster Map29 genes · 107,239 bp

20 kb107.2 kb visible · 107,239 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

28 steps · 27 edges
Step 1Load
jenA1
+Malonyl-CoA
Step 20
Start
+Glucose-1-P
Step 2M1
jenA1
+Methylmalonyl-CoA
Inactive: KR, DH
Step 21
jenG1
Step 3M2
jenA2
+Methylmalonyl-CoA
Step 22
jenG2
Step 4M3
jenA3
+Malonyl-CoA
Step 23
jenG3
Step 5M4
jenA3
+Methylmalonyl-CoA
Step 24
jenG4
Step 6M5
jenA4
+Methylmalonyl-CoA
Inactive: KR, DH
Step 25
jenG4
Step 7M6
jenA4
+Malonyl-CoA
Inactive: DH, ER
Step 26
jenG4
Step 8M7
jenA5
+Methylmalonyl-CoA
Step 27
jenM
Step 9M8
jenA5
+Malonyl-CoA
Step 10M9
jenA6
+Methylmalonyl-CoA
Inactive: KR
Step 11M10
jenA7
+Malonyl-CoA
Step 12M11
jenA8
+Methylmalonyl-CoA
Step 13M12
jenA8
+Methylmalonyl-CoA
Step 14M13
jenA10;jenA11
+Methylmalonyl-CoA
Step 15
jenI, jenO
Step 16
jenE
Step 17M14
jenA11
+Methylmalonyl-CoA
Step 18MCR
jenA11
Step 19
jenP1
Step 28
jenG5
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions28 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12559-1jenA1Loading
Malonyl-CoA
OC(C)=O—
22559-2jenA1M1
2559-1;Methylmalonyl-CoA
from: 2559-1
OC(C(C)C(C)=O)=O{'Inactive': ['KR', 'DH']}
32559-3jenA2M2
2559-2;Methylmalonyl-CoA
from: 2559-2
OC(C(C)CC(C)C(C)=O)=O—
42559-4jenA3M3
2559-3;Malonyl-CoA
from: 2559-3
OC(/C=C/C(C)CC(C)C(C)=O)=O—
52559-5jenA3M4
2559-4;Methylmalonyl-CoA
from: 2559-4
OC(C(C)C/C=C/C(C)CC(C)C(C)=O)=O—
62559-6jenA4M5
2559-5;Methylmalonyl-CoA
from: 2559-5
CC(C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)C(O)=O{'Inactive': ['KR', 'DH']}
72559-7jenA4M6
2559-6;Malonyl-CoA
from: 2559-6
CC(C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)C(O)CC(O)=O{'Inactive': ['DH', 'ER']}
82559-8jenA5M7
2559-7;Methylmalonyl-CoA
from: 2559-7
OC(/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O—
92559-9jenA5M8
2559-8;Malonyl-CoA
from: 2559-8
OC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O—
102559-10jenA6M9
2559-9;Methylmalonyl-CoA
from: 2559-9
OC(C(C)C(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O{'Inactive': ['KR']}
112559-11jenA7M10
2559-10;Malonyl-CoA
from: 2559-10
OC(CC(O)C(C)C(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O—
122559-12jenA8M11
2559-11;Methylmalonyl-CoA
from: 2559-11
OC(C(C)C(O)CC(O)C(C)C(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O—
132559-13jenA8M12
2559-12;Methylmalonyl-CoA
from: 2559-12
OC(/C(C)=C/C(C)C(O)CC(O)C(C)C(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O—
142559-14jenA10;jenA11M13
2559-13;Methylmalonyl-CoA
from: 2559-13
OC(C(C)C(/C(C)=C/C(C)C(O)CC(O)C(C)C(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O)=O—
152559-15jenI, jenO—
2559-14
from: 2559-14
OC(C(C)C(/C(C)=C/C(C)C(CC(C(C(CC/C(C)=C/CC(C(C)C(C(C)C/C=C\C(C)CC(C(C)=O)C)=O)O)=O)C)O)O)=O)=O—
162559-16jenE—
2559-15
from: 2559-15
OC(C(C)C(/C(C)=C/C(C)C1O[C@](CC[C@@]2(C(O3)CC(C(C)[C@]3(O4)[C@@H](C)CC4C(O5)C(C)CC(C5(O)C)C)O)C)(O2)C(C)C(O)C1)=O)=O—
172559-17jenA11M14
2559-16;Methylmalonyl-CoA
from: 2559-16
C/C(C(C(CC(C(O)=O)C)C)=O)=C\C(C)C1O[C@](CC[C@@]2(C(O3)CC(C(C)[C@]3(O4)[C@@H](C)CC4C(O5)C(C)CC(C5(O)C)C)O)C)(O2)C(C)C(O)C1—
182559-18jenA11MCR
2559-17
from: 2559-17
C/C(C(C(CC(C(O)=O)C)C)=O)=C\C(C)C1O[C@](CC[C@@]2(C(O3)CC(C(C)[C@]3(O4)[C@@H](C)CC4C(O5)C(C)CC(C5(O)C)C)O)C)(O2)C(C)C(O)C1—
192559-19jenP1—
2559-18
from: 2559-18
C/C(C(C(CC(C(O)=O)C)C)=O)=C\C(C)C1O[C@](CC[C@@]2(C(O3)CC(C(C)[C@]3(O4)[C@@H](C)CC4C(O5)C(C)CC(C5(O)CO)C)O)C)(O2)C(C)C(O)C1—
202559-20Start—
Glucose-1-P
O[C@H]1[C@H](O)[C@@H](O)[C@@H](OP([O-])([O-])=O)O[C@@H]1CO—
212559-21jenG1—
2559-20
from: 2559-20
O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[R])O[C@@H]1CO—
222559-22jenG2—
2559-21
from: 2559-21
C[C@H]1O[C@H](O[R])[C@H](O)[C@@H](O)C1=O—
232559-23jenG3—
2559-22
from: 2559-22
C[C@H]1O[C@H](O[R])C[C@@H](O)C1=O—
242559-24jenG4—
2559-23
from: 2559-23
C[C@H]1O[C@H](O[R])CCC1=O—
252559-25jenG4—
2559-24
from: 2559-24
[R]O[C@@H]1CCC([C@H](C)O1)=O—
262559-26jenG4—
2559-25
from: 2559-25
[R]O[C@@H]1CC[C@H](O)[C@H](C)O1—
272559-27jenM—
2559-26
from: 2559-26
[R]O[C@@H]1CC[C@H](OC)[C@H](C)O1—
282559jenG5—
2559-19;2559-27
from: 2559-19, 2559-27
C/C(C(C(CC(C(O)=O)C)C)=O)=C\C(C)C1O[C@](CC[C@@]2(C(O3)CC(C(C)[C@]3(O4)[C@@H](C)CC4C(O5)C(C)CC(C5(O)C)C)O)C)(O2)C(C)C(OC6OC(C)C(OC)CC6)C1—
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