NPdia
← Back to Repository
BGC0002552PKS

Ansacarbamitocin

Producing organism
Amycolatopsis sp. CP2808
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
PKS (Unknown)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
Loading…
ansacarbamitocin

Gene Cluster Map48 genes · 82,440 bp

KSKSKSCALKSKSKSKS20 kb82.4 kb visible · 82,440 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1Load
acmA
+AHBA
Step 13
Start
Step 2M1
acmA
+Methylmalonyl-CoA
Step 3M2
acmA
+Malonyl-CoA
Step 4M3
acmB
+Methoxymalonyl-ACP
Step 5M4
acmB
+Malonyl-CoA
Step 6M5
acmC
+Methylmalonyl-CoA
Step 7M6
acmD
+Methylmalonyl-CoA
Step 8M7
acmD
+Malonyl-CoA
Step 9TE
acmD
Step 10
acm12
Step 11
acm21a, acm21b
Step 12
acm11
Step 14
acm25
Step 15
acmN
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12552-1acmALoading
AHBA
O=C(C1=CC(O)=CC(N)=C1)O—
22552-2acmAM1
2552-1;Methylmalonyl-CoA
from: 2552-1
OC1=CC(N)=CC(CC(C)C(O)=O)=C1—
32552-3acmAM2
2552-2;Malonyl-CoA
from: 2552-2
OC1=CC(N)=CC(CC(C)/C=C/C(O)=O)=C1—
42552-4acmBM3
2552-3;Methoxymalonyl-ACP
from: 2552-3
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(O)=O)=C1—
52552-5acmBM4
2552-4;Malonyl-CoA
from: 2552-4
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)=O)=O)=C1—
62552-6acmCM5
2552-5;Methylmalonyl-CoA
from: 2552-5
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)C(C)C(O)=O)=O)=C1—
72552-7acmDM6
2552-6;Methylmalonyl-CoA
from: 2552-6
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)C(C)/C=C(C)/C(O)=O)=O)=C1—
82552-8acmDM7
2552-7;Malonyl-CoA
from: 2552-7
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)C(C)/C=C(C)/C(O)CC(O)=O)=O)=C1—
92552-9acmDTE
2552-8
from: 2552-8
OC1=CC(C/C(C)=C/C=C/[C@@H]2OC)=CC(NC(CC(O)/C(C)=C/C(C(CC2=O)O)C)=O)=C1—
102552-10acm12—
2552-9
from: 2552-9
OC1=CC(C/C(C)=C/C=C/[C@@H]2OC)=CC(NC(CC(O)/C(C)=C/C(C(CC2=O)O)C)=O)=C1Cl—
112552-11acm21a, acm21b—
2552-10
from: 2552-10
OC1=CC(C/C(C)=C/C=C/[C@@H]2OC)=CC(NC(CC(OC(NC)=O)/C(C)=C/C(C(C[C@@]2(O)N3)OC3=O)C)=O)=C1Cl—
122552-12acm11—
2552-11
from: 2552-11
OC1=CC(C/C(C)=C/C=C/[C@@H]2OC)=CC(NC(CC(OC(NC)=O)[C@@](C3C(C(C[C@@]2(O)N4)OC4=O)C)(O3)C)=O)=C1Cl—
132552-13Start—
NC(O[C@H]1C(O)[C@@H](O)[C@H](O)C[C@@H]1COC(C)=O)=O—
142552-14acm25—
2552-12;2552-13
from: 2552-12, 2552-13
OC1=CC(C/C(C)=C/C=C/[C@@H]2OC)=CC(N([C@@H]3[C@@H](O)C(O)[C@@H](OC(N)=O)[C@H](COC(C)=O)C3)C(CC(OC(NC)=O)[C@@](C4C(C(C[C@@]2(O)N5)OC5=O)C)(O4)C)=O)=C1Cl—
152552acmN—
2552-14
from: 2552-14
OC1=CC(C/C(C)=C/C=C/[C@@H]2OC)=CC(N([C@@H]3[C@@H](O)C(OC)[C@@H](OC(N)=O)[C@H](COC(C)=O)C3)C(CC(OC(NC)=O)[C@@](C4C(C(C[C@@]2(O)N5)OC5=O)C)(O4)C)=O)=C1Cl—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture