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BGC0002550PKS

Lobophorin CR4

Producing organism
Streptomyces olivaceus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
30
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map40 genes · 102,694 bp

20 kb102.7 kb visible · 102,694 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
AmTAminotransferase V
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

30 steps · 30 edges
Step 1Load
QFU80902.1
+Malonyl-CoA
Step 15
Start
Step 22
Start
+Glucose-1-P
Step 2M1
QFU80902.1
+Methylmalonyl-CoA
Step 16
QFU80894.1;QFU80895.1
Step 23
QFU80908.1
Step 3M2
QFU80902.1
+Malonyl-CoA
Step 17
QFU80893.1
Step 24
QFU80907.1
Step 4M3
QFU80902.1
+Methylmalonyl-CoA
Step 25
QFU80888.1
Step 5M4
QFU80901.1
+Malonyl-CoA
Inactive: DH
Step 26
QFU80909.1
Step 6M5
QFU80901.1;QFU80900.1
+Methylmalonyl-CoA
Step 27
QFU80910.1
Step 7M6
QFU80900.1
+Malonyl-CoA
Step 28
?
Step 8M7
QFU80900.1
+Malonyl-CoA
Step 9M8
QFU80899.1
+Methylmalonyl-CoA
Inactive: DH
Step 10M9
QFU80887.1
+Methylmalonyl-CoA
Step 11M10
QFU80887.1
+Methylmalonyl-CoA
Step 12M11
QFU80898.1
+Malonyl-CoA
Inactive: KR
Step 13
?
Step 14
?
Step 18
QFU80896.1
Step 19
QFU80893.1
Step 20
QFU80897.1
Step 21
QFU80897.1
Step 29
QFU80891.1
Step 30
QFU80892.1, QFU80882.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions30 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12550-1QFU80902.1Loading
Malonyl-CoA
O=C(C)O—
22550-2QFU80902.1M1
2550-1;Methylmalonyl-CoA
from: 2550-1
C/C=C(C)/C(O)=O—
32550-3QFU80902.1M2
2550-2;Malonyl-CoA
from: 2550-2
C/C=C(C)/C=C/C(O)=O—
42550-4QFU80902.1M3
2550-3;Methylmalonyl-CoA
from: 2550-3
C/C=C(C)/C=C/C=C(C)/C(O)=O—
52550-5QFU80901.1M4
2550-4;Malonyl-CoA
from: 2550-4
C/C=C(C)/C=C/C=C(C)/[C@H](O)CC(O)=O{'Inactive': ['DH']}
62550-6QFU80901.1;QFU80900.1M5
2550-5;Methylmalonyl-CoA
from: 2550-5
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C(O)=O—
72550-7QFU80900.1M6
2550-6;Malonyl-CoA
from: 2550-6
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C(O)=O—
82550-8QFU80900.1M7
2550-7;Malonyl-CoA
from: 2550-7
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/C(O)=O—
92550-9QFU80899.1M8
2550-8;Methylmalonyl-CoA
from: 2550-8
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C(O)=O)C{'Inactive': ['DH']}
102550-10QFU80887.1M9
2550-9;Methylmalonyl-CoA
from: 2550-9
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](C(O)=O)C)C—
112550-11QFU80887.1M10
2550-10;Methylmalonyl-CoA
from: 2550-10
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](/C=C(C(O)=O)\C)C)C—
122550-12QFU80898.1M11
2550-11;Malonyl-CoA
from: 2550-11
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](/C=C(C(CC(O)=O)=O)\C)C)C{'Inactive': ['KR']}
132550-13?—
2550-12
from: 2550-12
O=C(CC(O)=O)/C(C)=C/[C@@H](C)C[C@H](C)[C@H](O)/C=C/C=C/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
142550-14?—
2550-13
from: 2550-13
O=C(CC(O)=O)[C@]1(C)[C@](C=C[C@]2([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]21[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
152550-15Start—
O[C@H](COP(O)(O)=O)C(OP(O)(O)=O)=O—
162550-16QFU80894.1;QFU80895.1—
2550-15
from: 2550-15
O[C@H](CO)C(O)=O—
172550-17QFU80893.1—
2550-16
from: 2550-16
O[C@H](CO)C([R])=O—
182550-18QFU80896.1—
2550-14;2550-17
from: 2550-14, 2550-17
O=C(/C(C(O)=O)=C(O)/C(CO)O)[C@]1(C)[C@](C=C[C@]2([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]21[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
192550-19QFU80893.1—
2550-18
from: 2550-18
O=C(C1=C(O)C(CO)OC1=O)[C@]2(C)[C@](C=C[C@]3([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]32[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
202550-20QFU80897.1—
2550-19
from: 2550-19
O=C(C(C(O1)=O)=C(O)C1=C)[C@]2(C)[C@](C=C[C@]3([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]32[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
212550-21QFU80897.1—
2550-20
from: 2550-20
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/[C@@](C=C5C)([H])[C@@]21C[C@H]5C—
222550-22Start—
Glucose-1-P
O[C@H]1[C@H](O)[C@@H](O)[C@@H](OP([O-])([O-])=O)O[C@@H]1CO—
232550-23QFU80908.1—
2550-22
from: 2550-22
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
242550-24QFU80907.1—
2550-23
from: 2550-23
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
252550-25QFU80888.1—
2550-24
from: 2550-24
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
262550-26QFU80909.1—
2550-25
from: 2550-25
[R][C@@H](O[C@@H]1C)C[C@@H](O)C1=O—
272550-27QFU80910.1—
2550-26
from: 2550-26
[R][C@@H]1C[C@@H](O)C([C@H](C)O1)=O—
282550-28?—
2550-27
from: 2550-27
[R][C@@H]1C[C@@H](O)[C@@H](O)[C@H](C)O1—
292550-29QFU80891.1—
2550-21;2550-28;2550-28
from: 2550-21, 2550-28, 2550-28
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O[C@H]5C[C@@H](O[C@H]6C[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](C)O5)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/[C@@](C=C7C)([H])[C@@]21C[C@H]7C—
302550QFU80892.1, QFU80882.1—
2550-29;2550-28
from: 2550-29, 2550-28
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O[C@H]5C[C@@H](O[C@H]6C[C@@H](O)[C@@H](O[C@@H]7C[C@@H](O)[C@@H](OC)[C@H](C)O7)[C@H](C)O6)[C@@H](O)[C@H](C)O5)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/[C@@](C=C8C)([H])[C@@]21C[C@H]8C—
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