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BGC0002544NRPS

Amychelin A;Amychelin B

Producing organism
Amycolatopsis methanolica
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis›Amycolatopsis methanolica group
Biosynthetic class
NRPS (Type I)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map18 genes · 39,399 bp

ACACAECAECACAECyA10 kb39.4 kb visible · 39,399 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
EEpimerization (E)
CyHeterocyclization (Cy)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1
Start
+Chorismate
Step 2
AMET_0595
Step 3
AMET_0598;AMET_0602
Step 4
AMET_0602
+Serine
Step 5
AMET_0602
+Serine
Step 6
AMET_0602
+Serine
Step 7
AMET_0603
+Serine
Step 8
AMET_0603
+N-Hydroxy-N-formy…
Step 9
AMET_0604
+N-Hydroxy-ornithi…
Step 10
AMET_0600
Step 11
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12544-1Start—
Chorismate
OC(C1=C[C@@H](CC(C(O)=O)=C)[C@H](O)C=C1)=O—
22544-2AMET_0595—
2544-1
from: 2544-1
OC(C1=CC=CC=C1O)=O—
32544-3AMET_0598;AMET_0602—
2544-2
from: 2544-2
OC(C1=CC=CC=C1O)=O—
42544-4AMET_0602—
2544-3;Serine
from: 2544-3
OC1=CC=CC=C1C2=N[C@@H](C(O)=O)CO2—
52544-5AMET_0602—
2544-4;Serine
from: 2544-4
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(O)=O)=O)CO2—
62544-6AMET_0602—
2544-5;Serine
from: 2544-5
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(O)=O)=O)=O)CO2—
72544-7AMET_0603—
2544-6;Serine
from: 2544-6
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(N[C@@H](CC)C(O)=O)=O)=O)=O)CO2—
82544-8AMET_0603—
2544-7;N-Hydroxy-N-formyl-ornithine
from: 2544-7
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(N[C@@H](CC)C(N[C@H](CCCN(C(C)=O)O)C(O)=O)=O)=O)=O)=O)CO2—
92544-9AMET_0604—
2544-8;N-Hydroxy-ornithine
from: 2544-8
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(N[C@@H](CC)C(N[C@H](CCCN(C(C)=O)O)C(N[C@H](CCCNO)C(O)=O)=O)=O)=O)=O)=O)CO2—
102544(1)AMET_0600—
2544-9
from: 2544-9
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CC)C(N[C@@H](CC)C(N[C@H](CCCN(C([H])=O)O)C(N[C@@H]3CCCN(O)C3=O)=O)=O)=O)=O)=O)CO2—
112544(2)?—
2544-9
from: 2544-9
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(N[C@@H](CC)C(N[C@H](CCCN(C([H])=O)O)C(N[C@H](CCCNO)C(O)=O)=O)=O)=O)=O)=O)CO2—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture