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BGC0002540PKS

Tetramycin B

Producing organism
Streptomyces hygrospinosus subsp. beijingensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
19
DOI
MIBiG entry
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tetramycin B

Gene Cluster Map20 genes · 108,563 bp

20 kb108.6 kb visible · 108,563 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
DnDocking N-term
DcDocking C-term
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1Load
tetrA
+Malonyl-CoA
Step 16
Start
+Fructose-6-phosph…
Step 2M1
tetrB
Step 17
tetrMI, tetrMII
Step 3M2
tetrB
Step 4M3
tetrB
Step 5M4
tetrB
Step 6M5
tetrC
Step 7M6
tetrC
Step 8M7
tetrC
Step 9M8
tetrC
Step 10M9
tetrC
Inactive: KR
Step 11M10
tetrC
Step 12M11
tetrD
Inactive: DH
Step 13M12
tetrE
Inactive: ER
Step 14TE
tetrE
Step 15
tetrG
Step 18
tetrMIII
Step 19
tetrK
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12540-1tetrALoading
Malonyl-CoA
O=C(C)O—
22540-2tetrBM1
2540-1
from: 2540-1
OC(C)C(CC)C(O)=O—
32540-3tetrBM2
2540-2
from: 2540-2
OC(C)C(CC)/C=C/C(O)=O—
42540-4tetrBM3
2540-3
from: 2540-3
OC(C)C(CC)/C=C/C=C/C(O)=O—
52540-5tetrBM4
2540-4
from: 2540-4
OC(C)C(CC)/C=C/C=C/C=C/C(O)=O—
62540-6tetrCM5
2540-5
from: 2540-5
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)=O—
72540-7tetrCM6
2540-6
from: 2540-6
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(O)=O—
82540-8tetrCM7
2540-7
from: 2540-7
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)=O—
92540-9tetrCM8
2540-8
from: 2540-8
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(O)=O—
102540-10tetrCM9
2540-9
from: 2540-9
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)=O)=O{'Inactive': ['KR']}
112540-11tetrCM10
2540-10
from: 2540-10
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)CC(O)=O)=O—
122540-12tetrDM11
2540-11
from: 2540-11
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)CC(O)CC(O)=O)=O{'Inactive': ['DH']}
132540-13tetrEM12
2540-12
from: 2540-12
OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)CC(O)C/C=C/C(O)=O)=O{'Inactive': ['ER']}
142540-14tetrETE
2540-13
from: 2540-13
OC1C/C=C/C(OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(C(C)C(O)C2)OC2(O)CC(C1)O)=O—
152540-15tetrG—
2540-14
from: 2540-14
OC1C/C=C/C(OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O)CC(C(C(O)=O)C(O)C2)OC2(O)CC(C1)O)=O—
162540-16Start—
Fructose-6-phosphate
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@](O)(CO)[C@H]1O—
172540-17tetrMI, tetrMII—
2540-16
from: 2540-16
O[C@@H]1[C@@H]([R])O[C@@H](C)[C@H](O)[C@H]1N—
182540-18tetrMIII—
2540-15;2540-17
from: 2540-15, 2540-17
OC1C/C=C/C(OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O[C@H]2O[C@@H](C)[C@H](O)[C@H](N)[C@@H]2O)CC(C(C(O)=O)C(O)C3)OC3(O)CC(C1)O)=O—
192540tetrK—
2540-18
from: 2540-18
OC1C(O)/C=C/C(OC(C)C(CC)/C=C/C=C/C=C/C=C/C(O[C@H]2O[C@@H](C)[C@H](O)[C@H](N)[C@@H]2O)CC(C(C(O)=O)C(O)C3)OC3(O)CC(C1)O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture