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BGC0002526PKS

K-41A

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
23
DOI
MIBiG entry
View on MIBiG ↗
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K-41A

Gene Cluster Map41 genes · 115,748 bp

20 kb115.7 kb visible · 115,748 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

23 steps · 22 edges
Step 1Load
pak4
+Malonyl-CoA
Step 22
Start
Step 2M1
pak4;pak5
+Methylmalonyl-CoA
Inactive: KR
Step 3M2
pak5
+Methylmalonyl-CoA
Step 4M3
pak6
+Malonyl-CoA
Step 5M4
pak6
+Malonyl-CoA
Step 6M5
pak7;pak8
+Malonyl-CoA
Step 7M6
pak8
+Malonyl-CoA
Step 8M7
pak9
+Malonyl-CoA
Step 9M8
pak9
+Methylmalonyl-CoA
Step 10M9
pak10
+Methylmalonyl-CoA
Inactive: KR
Step 11M10
pak30
+Malonyl-CoA
Step 12M11
pak30
+Malonyl-CoA
Step 13M12
pak30
+Methylmalonyl-CoA
Step 14M13
pak29
+Methylmalonyl-CoA
Inactive: DH
Step 15M14
pak28
+Malonyl-CoA
Inactive: DH
Step 16
pak22;pak19
Step 17
?
Step 18
pak23, pak27
Step 19
pak24, pak25
Step 20
pak12, (pak14, pak18, p…
Step 21
pak13, pak15, pak20, pa…
Step 23
pak16
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12526-1pak4Loading
Malonyl-CoA
O=C(C)O—
22526-2pak4;pak5M1
2526-1;Methylmalonyl-CoA
from: 2526-1
O=C(C)[C@H](C(O)=O)C{'Inactive': ['KR']}
32526-3pak5M2
2526-2;Methylmalonyl-CoA
from: 2526-2
O=C(C)[C@H](C[C@@H](C)C(O)=O)C—
42526-4pak6M3
2526-3;Malonyl-CoA
from: 2526-3
O=C(C)[C@H](C[C@@H](C)/C=C/C(O)=O)C—
52526-5pak6M4
2526-4;Malonyl-CoA
from: 2526-4
O=C(C)[C@H](C[C@@H](C)/C=C/CCC(O)=O)C—
62526-6pak7;pak8M5
2526-5;Malonyl-CoA
from: 2526-5
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/C(O)=O)C—
72526-7pak8M6
2526-6;Malonyl-CoA
from: 2526-6
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CCC(O)=O)C—
82526-8pak9M7
2526-7;Malonyl-CoA
from: 2526-7
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C(O)=O)\C)C—
92526-9pak9M8
2526-8;Methylmalonyl-CoA
from: 2526-8
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C(O)=O)C)\C)C—
102526-10pak10M9
2526-9;Methylmalonyl-CoA
from: 2526-9
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C([C@H](C(O)=O)C)=O)C)\C)C{'Inactive': ['KR']}
112526-11pak30M10
2526-10;Malonyl-CoA
from: 2526-10
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C([C@H]([C@H](O)CC(O)=O)C)=O)C)\C)C—
122526-12pak30M11
2526-11;Malonyl-CoA
from: 2526-11
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C([C@H]([C@H](O)C[C@@H](O)CC(O)=O)C)=O)C)\C)C—
132526-13pak30M12
2526-12;Methylmalonyl-CoA
from: 2526-12
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C([C@H]([C@H](O)C[C@@H](O)C[C@@H](O)[C@@H](C(O)=O)C)C)=O)C)\C)C—
142526-14pak29M13
2526-13;Methylmalonyl-CoA
from: 2526-13
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C([C@H]([C@H](O)C[C@@H](O)C[C@@H](O)[C@@H]([C@@H](O)[C@H](C(O)=O)C)C)C)=O)C)\C)C{'Inactive': ['DH']}
152526-15pak28M14
2526-14;Malonyl-CoA
from: 2526-14
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C([C@H]([C@H](O)C[C@@H](O)C[C@@H](O)[C@@H]([C@@H](O)[C@H](C(CC(O)=O)=O)C)C)C)=O)C)\C)C{'Inactive': ['DH']}
162526-16pak22;pak19—
2526-15
from: 2526-15
O=C(C)[C@H](C[C@@H](C)/C=C/CC/C=C/CC/C=C(C[C@H](C([C@H]([C@H](O)C[C@@H](O)C[C@@H](O)[C@@H]([C@@H](O)[C@H](C(CC(O)=O)=O)C)C)C)=O)C)\C)C—
172526-17?—
2526-16
from: 2526-16
O=C(CC(O)=O)[C@@H](C)[C@H](O)[C@@H]([C@@H](O)C[C@H](C[C@H]([C@@H](C)C([C@@H](C/C(C)=C/CC/C([H])=C/CC/C([H])=C/[C@H](C[C@@H](C)C(C)=O)C)C)=O)O)O)C—
182526-18pak23, pak27—
2526-17
from: 2526-17
O=C(CC(O)=O)[C@@H](C)[C@H](O)[C@@H]([C@@H](O)C[C@H](C[C@H]([C@@H](C)C([C@H](C)C[C@](C)(O1)[C@@]1([H])CC[C@]([H])(O2)[C@@]2([H])CC[C@@]([H])(O3)[C@]3([C@@H](C)C[C@@H](C)C(C)=O)[H])=O)O)O)C—
192526-19pak24, pak25—
2526-18
from: 2526-18
C[C@@H]([C@H](O)[C@@H]([C@]1([H])C[C@](O2)([H])C[C@H]([C@@H](C)[C@]2(O3)[C@H](C)C[C@@]3(C)[C@]([H])(O4)CC[C@@]4([H])[C@]([H])(O5)CC[C@]5([H])[C@]([C@@H](C)C[C@@H](C)[C@]6(O)C)(O6)[H])O)C)[C@@](O1)(O)CC(O)=O—
202526-20pak12, (pak14, pak18, pak21)—
2526-19
from: 2526-19
C[C@@H]([C@H](O)[C@](O)(C)[C@]1([H])C[C@](O2)([H])C[C@H]([C@@H](C)[C@]2(O3)[C@H](C)[C@@H](O)[C@@]3(C)[C@]([H])(O4)CC[C@@]4([H])[C@]([H])(O5)CC[C@]5([H])[C@]([C@@H](C)[C@H](O)[C@@H](C)[C@]6(O)C)(O6)[H])O)[C@@](O1)(O)[C@@H](O)C(O)=O—
212526-21pak13, pak15, pak20, pak38—
2526-20
from: 2526-20
C[C@@H]([C@H](OC)[C@](OC)(C)[C@]1([H])C[C@](O2)([H])C[C@H]([C@@H](C)[C@]2(O3)[C@H](C)[C@@H](OC)[C@@]3(C)[C@]([H])(O4)CC[C@@]4([H])[C@]([H])(O5)CC[C@]5([H])[C@]([C@@H](C)[C@H](O)[C@@H](C)[C@]6(O)C)(O6)[H])OC)[C@@](O1)(O)[C@@H](O)C(O)=O—
222526-22Start—
O[C@@]1([H])CC[C@H](OC)[C@@H](C)O1—
232526-23pak16—
2526-21;2526-22
from: 2526-21, 2526-22
C[C@@H]([C@H](OC)[C@](OC)(C)[C@]1([H])C[C@](O2)([H])C[C@H]([C@@H](C)[C@]2(O3)[C@H](C)[C@@H](OC)[C@@]3(C)[C@]([H])(O4)CC[C@@]4([H])[C@]([H])(O5)CC[C@]5([H])[C@]([C@@H](C)[C@H](O[C@@]6([H])CC[C@H](OC)[C@@H](C)O6)[C@@H](C)[C@]7(O)C)(O7)[H])OC)[C@@](O1)(O)[C@@H](O)C(O)=O—
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