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BGC0002523NRPS

Desertomycin B;Desertomycin A;Desertomycin G

Producing organism
Streptomyces nobilis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
27
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map56 genes · 181,146 bp

50 kb181.1 kb visible · 181,146 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

27 steps · 26 edges
Step 1Load
dstA1
+Arginine
Step 25
Start
Step 2M1
dstA1
+Methylmalonyl-CoA
Step 3M2
dstA1
+Malonyl-CoA
Step 4M3
dstA1
+malonyl-CoA
Step 5M4
dstA2
+malonyl-CoA
Step 6M5
dstA2
+malonyl-CoA
Step 7M6
dstA3
+Methylmalonyl-CoA
Step 8M7
dstA3
+Methylmalonyl-CoA
Step 9M8
dstA3
+malonyl-CoA
Step 10M9
dstA4
+malonyl-CoA
Step 11M10
dstA4
+malonyl-CoA
Step 12M11
dstA4
+malonyl-CoA
Step 13M12
dstA5
+Methylmalonyl-CoA
Step 14M13
dstA5
+Methylmalonyl-CoA
Step 15M14
dstA5
+malonyl-CoA
Step 16M15
dstA6
+Methylmalonyl-CoA
Step 17M16
dstA6
+malonyl-CoA
Step 18M17
dstA7
+malonyl-CoA
Step 19M18
dstA7
+Methylmalonyl-CoA
Step 20M19
dstA7
+Methylmalonyl-CoA
Step 21M20
dstA8
+malonyl-CoA
Step 22M21
dstA8
+Methylmalonyl-CoA
Step 23TE
dstA8
Step 24
?
Step 26
?
Step 27
dstH
+2523(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions27 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12523-1dstA1Loading
Arginine
O=C(CCCNC(N)=N)O—
22523-2dstA1M1
2523-1;Methylmalonyl-CoA
from: 2523-1
O[C@H](CCCNC(N)=N)[C@H](C(O)=O)C—
32523-3dstA1M2
2523-2;Malonyl-CoA
from: 2523-2
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)CC(O)=O)C—
42523-4dstA1M3
2523-3;malonyl-CoA
from: 2523-3
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/C(O)=O)C—
52523-5dstA2M4
2523-4;malonyl-CoA
from: 2523-4
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)CC(O)=O)C—
62523-6dstA2M5
2523-5;malonyl-CoA
from: 2523-5
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CC(O)=O)C—
72523-7dstA3M6
2523-6;Methylmalonyl-CoA
from: 2523-6
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H](C(O)=O)C)C—
82523-8dstA3M7
2523-7;Methylmalonyl-CoA
from: 2523-7
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H](C(O)=O)C)C)C—
92523-9dstA3M8
2523-8;malonyl-CoA
from: 2523-8
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)CC(O)=O)C)C)C—
102523-10dstA4M9
2523-9;malonyl-CoA
from: 2523-9
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)CC(O)=O)C)C)C—
112523-11dstA4M10
2523-10;malonyl-CoA
from: 2523-10
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)CC(O)=O)C)C)C—
122523-12dstA4M11
2523-11;malonyl-CoA
from: 2523-11
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)CC(O)=O)C)C)C—
132523-13dstA5M12
2523-12;Methylmalonyl-CoA
from: 2523-12
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/C(O)=O)C)C)C—
142523-14dstA5M13
2523-13;Methylmalonyl-CoA
from: 2523-13
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)C(O)=O)C)C)C—
152523-15dstA5M14
2523-14;malonyl-CoA
from: 2523-14
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/C(O)=O)C)C)C—
162523-16dstA6M15
2523-15;Methylmalonyl-CoA
from: 2523-15
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/[C@H](O)[C@H](C(O)=O)C)C)C)C—
172523-17dstA6M16
2523-16;malonyl-CoA
from: 2523-16
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/[C@H](O)[C@H](/C=C/C(O)=O)C)C)C)C—
182523-18dstA7M17
2523-17;malonyl-CoA
from: 2523-17
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CCC(O)=O)C)C)C)C—
192523-19dstA7M18
2523-18;Methylmalonyl-CoA
from: 2523-18
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H](C(O)=O)C)C)C)C)C—
202523-20dstA7M19
2523-19;Methylmalonyl-CoA
from: 2523-19
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H]([C@H](O)[C@H](C(O)=O)C)C)C)C)C)C—
212523-21dstA8M20
2523-20;malonyl-CoA
from: 2523-20
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H]([C@H](O)[C@H](CCC(O)=O)C)C)C)C)C)C—
222523-22dstA8M21
2523-21;Methylmalonyl-CoA
from: 2523-21
O[C@H](CCCNC(N)=N)[C@H]([C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]([C@H](O)[C@H]([C@@H](O)C[C@@H](O)C[C@H](O)C[C@@H](O)C/C=C(C)/[C@H](O)[C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H]([C@H](O)[C@H](CC/C=C(C(O)=O)\C)C)C)C)C)C)C—
232523-23dstA8TE
2523-22
from: 2523-22
O=C1O[C@H]([C@H](C)C2CCC(O)O2)C/C=C/[C@H](C[C@@H](C[C@H]([C@H](C)[C@@H]([C@@H](C)[C@H](C[C@H](C[C@@H](C[C@@H](O)C/C=C(C)/[C@@H]([C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H]([C@H](O)[C@H](CC/C=C1\C)C)C)C)O)O)O)O)O)O)O)O—
242523-24?—
2523-23
from: 2523-23
O=C1O[C@H]([C@H](C)C2CCC(O)O2)C/C=C/[C@H](C[C@@H](C[C@H]([C@H](C)[C@@H]([C@@H](C)[C@H](C[C@H](C[C@@H](C[C@@H](O)[C@@H](O)/C=C(C)/[C@@H]([C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H]([C@H](O)[C@H](CC/C=C1\C)C)C)C)O)O)O)O)O)O)O)O—
252523-25Start—
O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
262523(1)?—
2523-24;2523-25
from: 2523-24, 2523-25
O=C1O[C@H]([C@H](C)C2CCC(O)O2)C/C=C/[C@H](C[C@@H](C[C@H]([C@H](C)[C@@H]([C@@H](C)[C@H](C[C@H](C[C@@H](C[C@@H](O)[C@@H](O[C@@H]3[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)/C=C(C)/[C@@H]([C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H]([C@H](O)[C@H](CC/C=C1\C)C)C)C)O)O)O)O)O)O)O)O—
272523(2)dstH—
2523(1)
O=C1O[C@H]([C@H](C)[C@H](O)CCCN)C/C=C/[C@H](C[C@@H](C[C@H]([C@H](C)[C@@H]([C@@H](C)[C@H](C[C@H](C[C@@H](C[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)/C=C(C)/[C@@H]([C@@H](C)/C=C/[C@H](O)[C@H](/C=C/CC[C@H](O)[C@@H]([C@H](O)[C@H](CC/C=C1\C)C)C)C)O)O)O)O)O)O)O)O—
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