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BGC0002520PKS

Quinolidomicin A

Producing organism
Micromonospora sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
49
DOI
MIBiG entry
View on MIBiG ↗
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quinolidomicin A

Gene Cluster Map59 genes · 231,984 bp

50 kb232.0 kb visible · 231,984 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
ACPSACP synthase
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

49 steps · 48 edges
Step 1
Start
+UDP-Glucose
Step 2
BCK51625.1
Step 3
BCK51624.1
Step 4
BCK51626.1
Step 5
BCK51621.1
Step 6
?
Step 7
?
Step 8
?
Step 9
BCK51631.1
Step 10
BCK51623.1
Step 11
BCK51624.1
Step 12
?
Step 13
?
Step 14Load
BCK51633.1
Step 15M1
BCK51633.1
+Malonyl-CoA
Inactive: DH
Step 16M2
BCK51633.1
+Methylmalonyl-CoA
Step 17M3
BCK51637.1
+Malonyl-CoA
Step 18M4
BCK51638.1
+Malonyl-CoA
Step 19M5
BCK51638.1
+Malonyl-CoA
Step 20M6
BCK51638.1
+Malonyl-CoA
Step 21M7
BCK51638.1
+Malonyl-CoA
Step 22M8
BCK51640.1
+Malonyl-CoA
Step 23M9
BCK51640.1
+Methylmalonyl-CoA
Step 24M10
BCK51640.1
+Malonyl-CoA
Step 25M11
BCK51640.1
+Malonyl-CoA
Step 26M12
BCK51641.1
+Malonyl-CoA
Step 27M13
BCK51641.1
+Malonyl-CoA
Step 28M14
BCK51641.1
+Malonyl-CoA
Step 29M15
BCK51641.1
+Malonyl-CoA
Step 30M16
BCK51641.1
+Malonyl-CoA
Step 31M17
BCK51641.1
+Malonyl-CoA
Inactive: KR
Step 32M18
BCK51642.1
+Malonyl-CoA
Step 33M19
BCK51642.1
+Malonyl-CoA
Step 34M20
BCK51643.1
+Malonyl-CoA
Step 35M21
BCK51643.1
+Malonyl-CoA
Step 36M22
BCK51643.1
+Malonyl-CoA
Step 37M23
BCK51644.1
+Malonyl-CoA
Step 38M24
BCK51644.1
+Methylmalonyl-CoA
Step 39M25
BCK51645.1
+Malonyl-CoA
Step 40M26
BCK51645.1
+Methylmalonyl-CoA
Step 41M27
BCK51645.1
+Methylmalonyl-CoA
Step 42M28
BCK51646.1
+Malonyl-CoA
Step 43M29
BCK51646.1
+Methylmalonyl-CoA
Step 44M30
BCK51647.1
+Methylmalonyl-CoA
Step 45M31
BCK51648.1
+Methylmalonyl-CoA
Step 46M32
BCK51648.1
+Malonyl-CoA
Step 47M33
BCK51649.1
+Malonyl-CoA
Inactive: KR
Step 48TE
BCK51649.1
Step 49
BCK51635.1, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions49 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12520-1Start—
UDP-Glucose
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
22520-2BCK51625.1—
2520-1
from: 2520-1
OC[C@H]1O[C@H]([R])[C@H](O)C([C@@H]1O)=O—
32520-3BCK51624.1—
2520-2
from: 2520-2
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](N)[C@@H]1O—
42520-4BCK51626.1—
2520-3
from: 2520-3
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](N)[C@@H]1O—
52520-5BCK51621.1—
2520-4
from: 2520-4
O[C@@H]1[C@@H](N)[C@H](O)[C@@H](CO[P])O[C@@H]1O—
62520-6?—
2520-5
from: 2520-5
[P]OC[C@H]1O[C@](O)(CO)[C@@H](N)[C@@H]1O—
72520-7?—
2520-6
from: 2520-6
N=C[C@@](O)([H])[C@@](CO[P])(O)[H]—
82520-8?—
2520-7
from: 2520-7
[H]C(N)(C([H])(C(C(O)=O)=O)[H])C(O)([H])C(CO[P])(O)[H]—
92520-9BCK51631.1—
2520-8
from: 2520-8
O=C([C@@]1(O)C[C@H]([C@H](O)C(C1)=O)N)O—
102520-10BCK51623.1—
2520-9
from: 2520-9
O=C(C(C[C@H]1N)=CC([C@H]1O)=O)O—
112520-11BCK51624.1—
2520-10
from: 2520-10
O=C(C1=CC(N)=CC(O)=C1)O—
122520-12?—
2520-11
from: 2520-11
O=C(C(C(C(N)=C1)=O)=CC1=O)O—
132520-13?—
2520-12
from: 2520-12
O=C(C(C(C(N)=C1)=O)=C(SC)C1=O)O—
142520-14BCK51633.1Loading
2520-13
from: 2520-13
O=C(C(C(C(N)=C1)=O)=C(SC)C1=O)O—
152520-15BCK51633.1M1
2520-14;Malonyl-CoA
from: 2520-14
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC(O)=O{'Inactive': ['DH']}
162520-16BCK51633.1M2
2520-15;Methylmalonyl-CoA
from: 2520-15
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](C(O)=O)C—
172520-17BCK51637.1M3
2520-16;Malonyl-CoA
from: 2520-16
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C(O)=O)C—
182520-18BCK51638.1M4
2520-17;Malonyl-CoA
from: 2520-17
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/C(O)=O)C—
192520-19BCK51638.1M5
2520-18;Malonyl-CoA
from: 2520-18
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)CC(O)=O)C—
202520-20BCK51638.1M6
2520-19;Malonyl-CoA
from: 2520-19
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)CC(O)=O)C—
212520-21BCK51638.1M7
2520-20;Malonyl-CoA
from: 2520-20
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CC(O)=O)C—
222520-22BCK51640.1M8
2520-21;Malonyl-CoA
from: 2520-21
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC(O)=O)C—
232520-23BCK51640.1M9
2520-22;Methylmalonyl-CoA
from: 2520-22
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](C(O)=O)C)C—
242520-24BCK51640.1M10
2520-23;Malonyl-CoA
from: 2520-23
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CCC(O)=O)C)C—
252520-25BCK51640.1M11
2520-24;Malonyl-CoA
from: 2520-24
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)CC(O)=O)C)C—
262520-26BCK51641.1M12
2520-25;Malonyl-CoA
from: 2520-25
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)CC(O)=O)C)C—
272520-27BCK51641.1M13
2520-26;Malonyl-CoA
from: 2520-26
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C(O)=O)C)C—
282520-28BCK51641.1M14
2520-27;Malonyl-CoA
from: 2520-27
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C(O)=O)C)C—
292520-29BCK51641.1M15
2520-28;Malonyl-CoA
from: 2520-28
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/C(O)=O)C)C—
302520-30BCK51641.1M16
2520-29;Malonyl-CoA
from: 2520-29
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(O)=O)C)C—
312520-31BCK51641.1M17
2520-30;Malonyl-CoA
from: 2520-30
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(CC(O)=O)=O)C)C{'Inactive': ['KR']}
322520-32BCK51642.1M18
2520-31;Malonyl-CoA
from: 2520-31
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)CC(O)=O)=O)C)C—
332520-33BCK51642.1M19
2520-32;Malonyl-CoA
from: 2520-32
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C(O)=O)=O)C)C—
342520-34BCK51643.1M20
2520-33;Malonyl-CoA
from: 2520-33
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/C(O)=O)=O)C)C—
352520-35BCK51643.1M21
2520-34;Malonyl-CoA
from: 2520-34
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)CC(O)=O)=O)C)C—
362520-36BCK51643.1M22
2520-35;Malonyl-CoA
from: 2520-35
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)CC(O)=O)=O)C)C—
372520-37BCK51644.1M23
2520-36;Malonyl-CoA
from: 2520-36
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O)=O)C)C—
382520-38BCK51644.1M24
2520-37;Methylmalonyl-CoA
from: 2520-37
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)C(O)=O)=O)C)C—
392520-39BCK51645.1M25
2520-38;Malonyl-CoA
from: 2520-38
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)CC(O)=O)=O)C)C—
402520-40BCK51645.1M26
2520-39;Methylmalonyl-CoA
from: 2520-39
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)C(O)=O)=O)C)C—
412520-41BCK51645.1M27
2520-40;Methylmalonyl-CoA
from: 2520-40
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C(O)=O)=O)C)C—
422520-42BCK51646.1M28
2520-41;Malonyl-CoA
from: 2520-41
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C(O)=O)=O)C)C—
432520-43BCK51646.1M29
2520-42;Methylmalonyl-CoA
from: 2520-42
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(C(O)=O)\C)=O)C)C—
442520-44BCK51647.1M30
2520-43;Methylmalonyl-CoA
from: 2520-43
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C([C@@H](O)[C@@H](C(O)=O)C)\C)=O)C)C—
452520-45BCK51648.1M31
2520-44;Methylmalonyl-CoA
from: 2520-44
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C([C@@H](O)[C@@H]([C@@H](O)[C@H](C(O)=O)C)C)\C)=O)C)C—
462520-46BCK51648.1M32
2520-45;Malonyl-CoA
from: 2520-45
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C([C@@H](O)[C@@H]([C@@H](O)[C@H]([C@H](O)CC(O)=O)C)C)\C)=O)C)C—
472520-47BCK51649.1M33
2520-46;Malonyl-CoA
from: 2520-46
O[C@H](C(C(C(N)=C1)=O)=C(SC)C1=O)CC[C@@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@H](O)CCCC[C@@H](CC[C@H](O)C[C@H](O)C/C=C/C=C/C=C/[C@H](O)CC(C[C@H](O)C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C([C@@H](O)[C@@H]([C@@H](O)[C@H]([C@H](O)CC(CC(O)=O)=O)C)C)\C)=O)C)C{'Inactive': ['KR']}
482520-48BCK51649.1TE
2520-47
from: 2520-47
O[C@@H](/C=C/C=C/C=C/C[C@H](C[C@H](CC[C@@H](C)CCCC[C@H](C[C@H](C[C@@H](/C=C/C=C/[C@H](CC[C@@H](C(C(C(N)=C1)=O)=C(SC)C1=O)O)C)OC(CC2(O)O[C@H]3[C@@H](C)[C@H](O)C2)=O)O)O)O)O)CC(C[C@@H](C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(C)/[C@@H](O)[C@@H]3C)O)=O—
492520BCK51635.1, ?—
2520-48
from: 2520-48
O[C@@H](/C=C/C=C/C=C/C[C@H](C[C@H](CC[C@@H](C)CCCC[C@H](C[C@H](C[C@@H](/C=C/C=C/[C@H](CC[C@@H](C(C(C(N)=C1)=O)=C(SC)C1=O)OC)C)OC(CC2(O)O[C@H]3[C@@H](C)[C@H](O)C2)=O)O)O)O)O)CC(C[C@@H](C/C=C/C=C/[C@H](O)C[C@H](O)C[C@H](O)CC[C@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)/C(C)=C/C=C\C(C)[C@@H](O)[C@@H]3C)O)=O—
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