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BGC0002517PKS

Tripartilactam;Niizalactam C

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗
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niizalactam C

Gene Cluster Map25 genes · 73,855 bp

KSKSKSKSAAKSKSKSKSKSKS10 kb73.9 kb visible · 73,855 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1
Start
+L-Glutamic acid
Step 2
triC, triD
Step 3
triF;triH
Step 4
triE
Step 5
triG
Step 6Load
triI;triA1
Step 7M1
triA1
+Malonyl-CoA
Step 8M2
triA1
+Malonyl-CoA
Step 9M3
triA2
+Methylmalonyl-CoA
Step 10M4
triA2
+Malonyl-CoA
Step 11M2026-05-06 00:00:00
triA3, triA4
Iterative
Step 12M7
triA5
+Malonyl-CoA
Step 13M8
triA5
+Methylmalonyl-CoA
Step 14M9
triA5
+Malonyl-CoA
Step 15M10
triA6
+Malonyl-CoA
Step 16
triJ
Step 17TE
triA6, (triK, triL)
Step 18
Step 19
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12517-1Start—
L-Glutamic acid
O=C([C@@H](N)CCC(O)=O)O—
22517-2triC, triD—
2517-1
from: 2517-1
O=C([C@@H](C)[C@H](N)C(O)=O)O—
32517-3triF;triH—
2517-2
from: 2517-2
O=C([C@@H](C)[C@H](N)C(O)=O)O—
42517-4triE—
2517-3
from: 2517-3
O=C([C@H](C)CN)O—
52517-5triG—
2517-4
from: 2517-4
O=C([C@H](C)CNC([R])=O)O—
62517-6triI;triA1Loading
2517-5
from: 2517-5
O=C([C@H](C)CNC([R])=O)O—
72517-7triA1M1
2517-6;Malonyl-CoA
from: 2517-6
C[C@H](CNC([R])=O)/C=C/C(O)=O—
82517-8triA1M2
2517-7;Malonyl-CoA
from: 2517-7
C[C@H](CNC([R])=O)/C=C/C=C/C(O)=O—
92517-9triA2M3
2517-8;Methylmalonyl-CoA
from: 2517-8
C[C@H](CNC([R])=O)/C=C/C=C/C=C(C(O)=O)\C—
102517-10triA2M4
2517-9;Malonyl-CoA
from: 2517-9
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C(O)=O)C—
112517-11triA3, triA4M2026-05-06 00:00:00
2517-10
from: 2517-10
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](CC(O)=O)O)=O)C{'Iteration': [('triA3', ['D…
122517-12triA5M7
2517-11;Malonyl-CoA
from: 2517-11
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C(O)=O)O)=O)C—
132517-13triA5M8
2517-12;Methylmalonyl-CoA
from: 2517-12
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C=C(C(O)=O)\C)O)=O)C—
142517-14triA5M9
2517-13;Malonyl-CoA
from: 2517-13
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C=C(/C=C/C(O)=O)C)O)=O)C—
152517-15triA6M10
2517-14;Malonyl-CoA
from: 2517-14
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C=C(/C=C/C(CC(O)=O)=O)C)O)=O)C—
162517-16triJ—
2517-15
from: 2517-15
O=C(O)CC(/C=C/C(C)=C/C=C/C[C@H](O)CC(/C=C\C=C\C(C)=C\C=C\C=C\[C@H](C)CN)=O)=O—
172517-17triA6, (triK, triL)TE
2517-16
from: 2517-16
O=C(/C=C/C(C)=C/C=C/[C@@H](O)[C@H](O)[C@H](O)C(/C=C\C=C\C(C)=C\C=C\C=C\[C@@H](CN1)C)=O)CC1=O—
182517(1)—
2517-17
from: 2517-17
O[C@@H]1[C@H](O)C([C@]2([H])C=C[C@]3([H])/C=C/C=C/C=C/[C@@H](C)CNC(CC(/C=C/C(C)=C\[C@@]3([H])[C@]2([H])[C@H]1O)=O)=O)=O—
192517(2)?—
2517-17
from: 2517-17
C[C@H](/C=C/C=C/C=C(C)/[C@]([C@](/C=C\[C@@H](O)[C@@H](O)[C@H]1O)([H])[C@@]2([H])C1=O)([H])[C@@]2([H])/C=C(C)/C=C/C3=O)CNC(C3)=O—
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