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BGC0002500PKS

NFAT-133

Producing organism
Streptomyces pactum
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
13
DOI
MIBiG entry
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NFAT-133

Gene Cluster Map16 genes · 62,503 bp

KSATKSATKSATKSATERKSATKSATKSKSAT10 kb62.5 kb visible · 62,503 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Resistance
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1M1
nftM
+Acetyl-CoA, Methylmalonyl-CoA
Step 2M2
nftM
+Malonyl-CoA
Inactive: DH, KR
Step 3M3
nftK
+Methylmalonyl-CoA
Inactive: DH, KR, ER
Step 4M4
nftC
+Methylmalonyl-CoA
Inactive: DH
Step 5M5
nftL
+Malonyl-CoA
Step 6M6
nftL
+Methylmalonyl-CoA
Step 7M7
nftD
+Malonyl-CoA
Step 8M8
nftD
+Malonyl-CoA
Step 9TE
nftD
Step 10
?
Step 11
?
Step 12
?
Step 13
?
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12500-1nftMM1
Acetyl-CoA;Methylmalonyl-CoA
CC(C(O)=O)C(O)=O
22500-2nftMM2
2500-1;Malonyl-CoA
from: 2500-1
CC(C(CC(O)=O)=O)C(O)=O{'Inactive': ['DH', 'KR']}
32500-3nftKM3
2500-2;Methylmalonyl-CoA
from: 2500-2
CC(C(CC(C(C)C(O)=O)=O)=O)C(O)=O{'Inactive': ['DH', 'KR', 'E…
42500-4nftCM4
2500-3;Methylmalonyl-CoA
from: 2500-3
CC(C(CC(C(C)C(O)C(C(O)=O)C)=O)=O)C(O)=O{'Inactive': ['DH']}
52500-5nftLM5
2500-4;Malonyl-CoA
from: 2500-4
CC(C(CC(C(C)C(O)C(/C=C/C(O)=O)C)=O)=O)C(O)=O
62500-6nftLM6
2500-5;Methylmalonyl-CoA
from: 2500-5
CC(C(CC(C(C)C(O)C(/C=C/C=C(C)/C(O)=O)C)=O)=O)C(O)=O
72500-7nftDM7
2500-6;Malonyl-CoA
from: 2500-6
CC(C(CC(C(C)C(O)C(/C=C/C=C(C)/C=C/C(O)=O)C)=O)=O)C(O)=O
82500-8nftDM8
2500-7;Malonyl-CoA
from: 2500-7
CC(C(CC(C(C)C(O)C(/C=C/C=C(C)/C=C/C(CC(O)=O)=O)C)=O)=O)C(O)=O
92500-9nftDTE
2500-8
from: 2500-8
CC(C(C(C(CC(C(C)C(O)=O)=O)=O)C)O)/C=C/C=C(\C=C\C(CC(O)=O)=O)C
102500-10?
2500-9
from: 2500-9
CC(C(C(C(C([H])C(C(C)C(O)=O)=O)=O)C)O)/C=C/C=C(C/C=C/CCO)/C
112500-11?
2500-10
from: 2500-10
CC(C(C(C1=CC(O)=C(C)C(O1)=O)C)O)/C=C/C=C(C/C=C/CCO)/C
122500-12?
2500-11
from: 2500-11
C[C@H]([C@H]([C@@H](C1=CC(O)=C(C)C(O1)=O)C)O)C2=CC=C(C=C2/C=C/CO)C
132500?
2500-12
from: 2500-12
C[C@H]([C@H]([C@@H](C(C)=O)C)O)C1=CC=C(C=C1/C=C/CO)C
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture