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BGC0002479Hybrid

Miharamycin A;Miharamycin B

Producing organism
Streptomyces miharaensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown);NRPS (Type I);saccharide (None)
Total steps
19
DOI
MIBiG entry
—
Loading…

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1
Start
+Glucose
Step 6
Start
+α-Ketoglutarate
Step 12
Start
+Guanosine monopho…
Step 2
?
Step 7
mihB6;mihB5
Step 13
mihG
Step 3
mihB1;mihB3
Step 14
mihD
Step 4
mihB4
Step 5
mihB2
Step 8
mihB5
Step 9
?
Step 10
mihK, ?
Step 11
mihQ
Step 15
mihI
Step 16
mihE, (mihC1, mihC2)
Step 17
?
Step 18
mihA
+L-Arginine
Step 19
mihL
+2479(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12479-1Start—
Glucose
O[C@H]1[C@H](O)[C@@H](O)C(O)C[C@@H]1CO—
22479-2?—
2479-1
from: 2479-1
O=C(OP(O)(O)=O)[C@@H](COP(O)(O)=O)O—
32479-3mihB1;mihB3—
2479-2
from: 2479-2
O=C(O)[C@@H](CO)O—
42479-4mihB4—
2479-3
from: 2479-3
O=C(O)[C@@H](C=O)O—
52479-5mihB2—
2479-4
from: 2479-4
O=C(O)C(C(O)=O)O—
62479-6Start—
α-Ketoglutarate
O=C(O)C(CCC(O)=O)=O—
72479-7mihB6;mihB5—
2479-6
from: 2479-6
O=C(O)CCC(C(O)=O)=O—
82479-8mihB5—
2479-7;2479-5
from: 2479-7, 2479-5
O=C([C@H](C(O)=O)O)CCC(C(O)=O)=O—
92479-9?—
2479-8
from: 2479-8
O=C([C@H](C(O)=O)O)CCC(C(O)=O)=O—
102479-10mihK, ?—
2479-9
from: 2479-9
NC(C(O)=O)[C@H](CC([C@H]1O)=O)OC1=O—
112479-11mihQ—
2479-10
from: 2479-10
NC(C(O)=O)[C@H]1OC(O)[C@H](O)C(C1)=O—
122479-12Start—
Guanosine monophosphate
O=P(O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)NC3=O)=C3N=C2)[C@@H](O)[C@H]1O—
132479-13mihG—
2479-12
from: 2479-12
O=P(O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@@H](O)[C@H]1O—
142479-14mihD—
2479-13
from: 2479-13
NC(N=C1)=NC2=C1N=CN2—
152479-15mihI—
2479-11;2479-14
from: 2479-11, 2479-14
NC(C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](O)C(C1)=O—
162479-16mihE, (mihC1, mihC2)—
2479-15
from: 2479-15
NC(C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](O)[C@](O)(C(O)CO)C1—
172479-17?—
2479-16
from: 2479-16
N[C@H](C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](OC[C@@H]4O)[C@@]4(O)[C@@H]1O—
182479(1)mihA—
2479-17;L-Arginine
from: 2479-17
OC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](OC[C@@H]4O)[C@@]4(O)[C@@H]1O)=O—
192479(2)mihL—
2479(1)
OC([C@@H](NC([C@@H](N)CCCN(O)C(N)=N)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](OC[C@@H]4O)[C@@]4(O)[C@@H]1O)=O—
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