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BGC0002456Hybrid

Alchivemycin A;Alchivemycin B

Producing organism
Streptomyces sp. NBRC 109436
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown);NRPS (Type I)
Total steps
29
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map18 genes · 120,445 bp

20 kb120.4 kb visible · 120,445 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

29 steps · 28 edges
Step 1Load
QSV12655.1
+Malonyl-CoA
Step 2M2
QSV12655.1
+Methylmalonyl-CoA
Step 3M3
QSV12659.1
+Malonyl-CoA
Step 4M4
QSV12659.1
+Malonyl-CoA
Step 5M5
QSV12661.1
+Methylmalonyl-CoA
Step 6M6
QSV12661.1
+Malonyl-CoA
Step 7M7
QSV12662.1
+Malonyl-CoA
Step 8M8
QSV12662.1
+Methylmalonyl-CoA
Step 9M9
QSV12662.1
+Malonyl-CoA
Step 10M10
QSV12662.1
+Malonyl-CoA
Step 11M11
QSV12663.1
+Methylmalonyl-CoA
Step 12M12
QSV12663.1
+Methylmalonyl-CoA
Step 13M13
QSV12664.1
+Malonyl-CoA
Step 14M14
QSV12664.1
+Malonyl-CoA
Inactive: KR
Step 15M15
QSV12656.1
+Glycine
Step 16
?
Step 17
QSV12649.1
Step 18
QSV12652.1
Step 19
QSV12648.1
Step 20
QSV12648.1/QSV12649.1
Step 21
QSV12652.1/QSV12649.1
Step 22
QSV12648.1/QSV12652.1
Step 23
QSV12652.1/QSV12648.1/Q…
Step 24
QSV12651.1
Step 25
QSV12651.1/QSV12649.1
Step 26
QSV12647.1
Step 27
QSV12647.1/QSV12649.1
Step 28
QSV12650.1
Step 29
QSV12650.1/QSV12649.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions29 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12456-1QSV12655.1Loading
Malonyl-CoA
O=C(O)—
22456-2QSV12655.1M2
2456-1;Methylmalonyl-CoA
from: 2456-1
C/C=C(C(O)=O)\C—
32456-3QSV12659.1M3
2456-2;Malonyl-CoA
from: 2456-2
C/C=C(C(CC(O)=O)=O)\C—
42456-4QSV12659.1M4
2456-3;Malonyl-CoA
from: 2456-3
C/C=C(C(C[C@H](O)CC(O)=O)=O)\C—
52456-5QSV12661.1M5
2456-4;Methylmalonyl-CoA
from: 2456-4
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](C(O)=O)C)=O)\C—
62456-6QSV12661.1M6
2456-5;Malonyl-CoA
from: 2456-5
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCC(O)=O)C)=O)\C—
72456-7QSV12662.1M7
2456-6;Malonyl-CoA
from: 2456-6
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCCC(O)=O)C)=O)\C—
82456-8QSV12662.1M8
2456-7;Methylmalonyl-CoA
from: 2456-7
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C(O)=O)C)=O)\C—
92456-9QSV12662.1M9
2456-8;Malonyl-CoA
from: 2456-8
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C=C/C(O)=O)C)=O)\C—
102456-10QSV12662.1M10
2456-9;Malonyl-CoA
from: 2456-9
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C=C/C=C/C(O)=O)C)=O)\C—
112456-11QSV12663.1M11
2456-10;Methylmalonyl-CoA
from: 2456-10
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C=C/C=C/C[C@@H](C)C(O)=O)C)=O)\C—
122456-12QSV12663.1M12
2456-11;Methylmalonyl-CoA
from: 2456-11
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C=C/C=C/C[C@@H](C)C[C@H](C(O)=O)C)C)=O)\C—
132456-13QSV12664.1M13
2456-12;Malonyl-CoA
from: 2456-12
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C=C/C=C/C[C@@H](C)C[C@H](/C=C/C(O)=O)C)C)=O)\C—
142456-14QSV12664.1M14
2456-13;Malonyl-CoA
from: 2456-13
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C=C/C=C/C[C@@H](C)C[C@H](/C=C/C(CC(O)=O)=O)C)C)=O)\C{'Inactive': ['KR']}
152456-15QSV12656.1M15
2456-14;Glycine
from: 2456-14
C/C=C(C(C[C@H](O)C[C@H](O)[C@H](CCCC/C=C(C)/C=C/C=C/C[C@@H](C)C[C@H](/C=C/C(CC(NCC(O)=O)=O)=O)C)C)=O)\C—
162456-16?—
2456-15
from: 2456-15
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@](/C(C)=C/CCCC[C@@H]([C@H](C[C@H](CC(/C(C)=C/C)=O)[N@@]4C3=O)O)C)([H])C=C1—
172456-17QSV12649.1—
2456-16
from: 2456-16
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@](/C(C)=C/CCCC[C@@H]([C@H](C[C@H](CC(/C(C)=C/C)=O)[N@@]4C3=O)O)C)([H])[C@H]5[C@@H]1O5—
182456-18QSV12652.1—
2456-16
from: 2456-16
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@](/C(C)=C/CCCC[C@@H]([C@H](C[C@H](C[C@@H](O)/C(C)=C/C)[N@@]4C3=O)O)C)([H])C=C1—
192456-19QSV12648.1—
2456-16
from: 2456-16
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@]([C@]5([C@@H](O5)CCCC[C@@H]([C@H](C[C@H](CC(/C(C)=C/C)=O)[N@@]4C3=O)O)C)C)([H])C=C1—
202456-20QSV12648.1/QSV12649.1—
2456-17/2456-19
from: 2456-17/2456-19
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@]([C@]5([C@@H](O5)CCCC[C@@H]([C@H](C[C@H](CC(/C(C)=C/C)=O)[N@@]4C3=O)O)C)C)([H])[C@H]6[C@@H]1O6—
212456-21QSV12652.1/QSV12649.1—
2456-17/2456-18
from: 2456-17/2456-18
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@](/C(C)=C/CCCC[C@@H]([C@H](C[C@H](C[C@@H](O)/C(C)=C/C)[N@@]4C3=O)O)C)([H])[C@H]5[C@@H]1O5—
222456-22QSV12648.1/QSV12652.1—
2456-18/2456-19
from: 2456-18/2456-19
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@]([C@]5([C@@H](O5)CCCC[C@@H]([C@H](C[C@H](C[C@@H](O)/C(C)=C/C)[N@@]4C3=O)O)C)C)([H])C=C1—
232456-23QSV12652.1/QSV12648.1/QSV12649.1—
2456-20/2456-21/2456-22
from: 2456-20/2456-21/2456-22
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@]([C@]5([C@@H](O5)CCCC[C@@H]([C@H](C[C@H](C[C@@H](O)/C(C)=C/C)[N@@]4C3=O)O)C)C)([H])[C@H]6[C@@H]1O6—
242456-24QSV12651.1—
2456-22
from: 2456-22
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@]([C@]5([C@@H](O5)CCCC[C@@H]([C@H](C[C@H]([C@@H](O)[C@@H](O)/C(C)=C/C)[N@@]4C3=O)O)C)C)([H])C=C1—
252456-25QSV12651.1/QSV12649.1—
2456-23/2456-24
from: 2456-23/2456-24
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C(C3=C(O)C4)=O)[C@]([C@]5([C@@H](O5)CCCC[C@@H]([C@H](C[C@H]([C@@H](O)[C@@H](O)/C(C)=C/C)[N@@]4C3=O)O)C)C)([H])[C@H]6[C@@H]1O6—
262456-26QSV12647.1—
2456-24
from: 2456-24
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C3=O)[C@]([C@]4([C@@H](O4)CCCC[C@@H]([C@H](C[C@H]([C@@H](O)[C@@H](O)/C(C)=C/C)[N@]5CC(O)=C3C(O5)=O)O)C)C)([H])C=C1—
272456-27QSV12647.1/QSV12649.1—
2456-25/2456-26
from: 2456-25/2456-26
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C3=O)[C@]([C@]4([C@@H](O4)CCCC[C@@H]([C@H](C[C@H]([C@@H](O)[C@@H](O)/C(C)=C/C)[N@]5CC(O)=C3C(O5)=O)O)C)C)([H])[C@H]6[C@@H]1O6—
282456-28QSV12650.1—
2456-26
from: 2456-26
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C3=O)[C@]([C@]4([C@@H](O4)CCCC[C@@H]([C@H]([C@H](O)[C@H]([C@@H](O)[C@@H](O)/C(C)=C/C)[N@]5CC(O)=C3C(O5)=O)O)C)C)([H])C=C1—
292456QSV12650.1/QSV12649.1—
2456-27/2456-28
from: 2456-27/2456-28
[H][C@]12[C@]([C@H](C)C[C@H](C)C2)([H])[C@H](C3=O)[C@]([C@]4([C@@H](O4)CCCC[C@@H]([C@H]([C@H](O)[C@H]([C@@H](O)[C@@H](O)/C(C)=C/C)[N@]5CC(O)=C3C(O5)=O)O)C)C)([H])[C@H]6[C@@H]1O6—
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