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BGC0002454PKS

Venturicidin D;Venturicidin E;Venturicidin F;Venturicidin A

Producing organism
Streptomyces sp. NRRL S-4
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
25
DOI
MIBiG entry
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venturicidin A

Gene Cluster Map21 genes · 97,575 bp

20 kb97.6 kb visible · 97,575 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

25 steps · 24 edges
Step 1M1
venK
+Methylmalonyl-CoA
Step 15
Start
+α-D-glucose-1-pho…
Step 2M2
venK
+Methylmalonyl-CoA
Step 16
venA
Step 3M3
venK
+Methylmalonyl-CoA
Step 17
venB
Step 4M4
venJ
+Methylmalonyl-CoA
Step 18
venL
Step 5M5
venJ
+Methylmalonyl-CoA
Step 19
venM
Step 6M6
venI
+Methylmalonyl-CoA
Step 20
venN
Step 7M7
venI
+Malonyl-CoA
Step 21
venE
Step 8M8
venI
+Malonyl-CoA
Step 9M9
venH
+Malonyl-CoA
Step 10M10
venG
+Methylmalonyl-CoA
Step 11M11
venG
+Methylmalonyl-CoA
Inactive: DH
Step 12M12
venF
+Malonyl-CoA
Step 13M13
venF
+Malonyl-CoA
Inactive: AT
Step 14TE
venF
Step 22
venO
Step 23
?
+2454(1)
Step 24
?
+2454(1)
Step 25
?
+2454(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions25 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12454-1venKM1
Methylmalonyl-CoA
O=C(CC)O—
22454-2venKM2
2454-1;Methylmalonyl-CoA
from: 2454-1
O=C(CC)[C@H](C(O)=O)C—
32454-3venKM3
2454-2;Methylmalonyl-CoA
from: 2454-2
O=C(CC)[C@H]([C@@H](O)[C@@H](C(O)=O)C)C—
42454-4venJM4
2454-3;Methylmalonyl-CoA
from: 2454-3
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H](C(O)=O)C)C)C—
52454-5venJM5
2454-4;Methylmalonyl-CoA
from: 2454-4
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C(O)=O)C)C)C)C—
62454-6venIM6
2454-5;Methylmalonyl-CoA
from: 2454-5
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](C(O)=O)C)C)C)C)C—
72454-7venIM7
2454-6;Malonyl-CoA
from: 2454-6
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](/C=C/C(O)=O)C)C)C)C)C—
82454-8venIM8
2454-7;Malonyl-CoA
from: 2454-7
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](/C=C/[C@H](O)CC(O)=O)C)C)C)C)C—
92454-9venHM9
2454-8;Malonyl-CoA
from: 2454-8
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](/C=C/[C@H](O)CCCC(O)=O)C)C)C)C)C—
102454-10venGM10
2454-9;Methylmalonyl-CoA
from: 2454-9
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](/C=C/[C@H](O)CCC/C=C(C(O)=O)\C)C)C)C)C)C—
112454-11venGM11
2454-10;Methylmalonyl-CoA
from: 2454-10
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](/C=C/[C@H](O)CCC/C=C([C@@H](O)[C@H](C(O)=O)C)\C)C)C)C)C)C{'Inactive': ['DH']}
122454-12venFM12
2454-11;Malonyl-CoA
from: 2454-11
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](/C=C/[C@H](O)CCC/C=C([C@@H](O)[C@H](/C=C/C(O)=O)C)\C)C)C)C)C)C—
132454-13venFM13
2454-12;Malonyl-CoA
from: 2454-12
O=C(CC)[C@H]([C@@H](O)[C@@H](C[C@H]([C@@H](O)[C@@H](C[C@H](/C=C/[C@H](O)CCC/C=C([C@@H](O)/C(C)=C/CC(CC(O)=O)=O)\C)C)C)C)C)C{'Inactive': ['AT']}
142454-14venFTE
2454-13
from: 2454-13
C/C([C@@](C(C)=CC1)([H])O[C@@]1(O)C2)=C\CCC[C@@H](O)/C=C/[C@H](C)C[C@@H](C)[C@@H]([C@@H](C[C@H]([C@@H]([C@@H](C(CC)=O)C)O)C)C)OC2=O—
152454-15Start—
α-D-glucose-1-phosphate
O[C@H]1[C@H](O)[C@@H](O)[C@@H](OP([O-])([O-])=O)O[C@@H]1CO—
162454-16venA—
2454-15
from: 2454-15
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
172454-17venB—
2454-16
from: 2454-16
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1CO)C1=O—
182454-18venL—
2454-17
from: 2454-17
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
192454-19venM—
2454-18
from: 2454-18
O[C@H](C[C@@H]([R])O[C@@H]1C)C1=O—
202454-20venN—
2454-19
from: 2454-19
C[C@H]1O[C@H]([R])C[C@@H](O)[C@@H]1O—
212454-21venE—
2454-20
from: 2454-20
C[C@H]1O[C@H]([R])C[C@@H](OC(N)=O)[C@@H]1O—
222454(1)venO—
2454-14;2454-21
from: 2454-14, 2454-21
C/C([C@@](C(C)=CC1)([H])O[C@@]1(O)C2)=C\CCC[C@@H](O[C@H]3C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O3)/C=C/[C@H](C)C[C@@H](C)[C@@H]([C@@H](C[C@H]([C@@H]([C@@H](C(CC)=O)C)O)C)C)OC2=O—
232454(2)?—
2454(1)
C/C([C@@](C(C)=CC1)([H])O[C@@]1(OC)C2)=C\CCC[C@@H](O[C@H]3C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O3)/C=C/[C@H](C)C[C@@H](C)[C@@H]([C@](C[C@@]([C@]([C@](C(C([H])([H])C)=O)([H])C)([H])O)([H])C)([H])C)OC2=O—
242454(3)?—
2454(1)
C/C([C@@]([C@](C)([H])C1([H])[H])([H])O[C@@](C1([H])[H])(O)C2)=C\CCC[C@@H](O[C@H]3C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O3)/C=C/[C@H](C)C[C@@H](C)[C@@H]([C@@H](C[C@H]([C@@H]([C@@H](C(CC)=O)C)O)C)C)OC2=O—
252454(4)?—
2454(1)
C/C([C@@](C(C)=CC1)([H])O[C@@]1(O)C2)=C\CCC[C@@H](O[C@H]3C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O3)/C=C/[C@H](C)C[C@@H](C)[C@@H]([C@](C[C@@]([C@]([C@](C(C([H])([H])C)=O)([H])C)(O)[H])([H])C)([H])C)OC2=O—
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