NPdia
← Back to Repository
BGC0002453PKS

Ansaseomycin A;Ansaseomycin B

Producing organism
Streptomyces seoulensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
Loading…

Gene Cluster Map36 genes · 76,762 bp

CALKSKSKSKSKSKSKSKS20 kb76.8 kb visible · 76,762 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
MTMethyltransferase
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
Step 8Load
(QES95467.1, QES95469.1…
+AHBA
Step 2
?
Step 9M1
QES95474.1
+Methylmalonyl-CoA
Inactive: DH
Step 3
?
Step 10M2
QES95474.1
+Malonyl-CoA
Step 4
QES95487.1;QES95488.1
Step 11M3
QES95474.1
+Methylmalonyl-CoA
Inactive: KR
Step 5
QES95484.1, QES95485.1,…
Step 12
QES95468.1
Step 6
?
Step 13M4
QES95475.1
+Malonyl-CoA
Step 7
QES95489.1
Step 14M5
QES95476.1
+Methylmalonyl-CoA
Inactive: DH
Step 15M6
QES95477.1
Step 16M7
QES95478.1
+Malonyl-CoA
Step 17M8
QES95479.1
Iterative
Step 18
QES95480.1
Step 19
?
Step 20
Step 21
?
+2453(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12453-1Start—
CC(C(N)C(O)=O)C—
22453-2?—
2453-1
from: 2453-1
CC(C(C(O)=O)=O)C—
32453-3?—
2453-2
from: 2453-2
CC(C([R])=O)C—
42453-4QES95487.1;QES95488.1—
2453-3
from: 2453-3
CC(C(CC(O)=O)=O)—
52453-5QES95484.1, QES95485.1, QES95486.1—
2453-4
from: 2453-4
CC(C(O)CC(O)=O)C—
62453-6?—
2453-5
from: 2453-5
CC(/C=C/C(O)=O)C—
72453-7QES95489.1—
2453-6
from: 2453-6
CC(CC(C(O)=O)C(O)=O)C—
82453-8(QES95467.1, QES95469.1, QES95470.1, QES95471.1, QES95472.1QES95473.1, QES95483.1), QES95474.1Loading
AHBA
OC1=CC(N)=CC(C(O)=O)=C1—
92453-9QES95474.1M1
2453-8;Methylmalonyl-CoA
from: 2453-8
OC1=CC(N)=CC(C(O)C(C)C(O)=O)=C1{'Inactive': ['DH']}
102453-10QES95474.1M2
2453-9;Malonyl-CoA
from: 2453-9
OC1=CC(N)=CC(C(O)C(C)C(CC(O)=O)=O)=C1—
112453-11QES95474.1M3
2453-10;Methylmalonyl-CoA
from: 2453-10
OC1=CC(N)=CC(C(O)C(C)C(CC(C(C)C(O)=O)=O)=O)=C1{'Inactive': ['KR']}
122453-12QES95468.1—
2453-11
from: 2453-11
O=C(C(C)C(O)=O)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
132453-13QES95475.1M4
2453-12;Malonyl-CoA
from: 2453-12
O=C(/C(C)=C/CC(O)=O)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
142453-14QES95476.1M5
2453-13;Methylmalonyl-CoA
from: 2453-13
O=C(/C(C)=C/CC(O)C(C)C(O)=O)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
152453-15QES95477.1M6
2453-14;2453-7
from: 2453-14, 2453-7
O=C(/C(C)=C/CC(O)C(C)C(C(CC(C)C)C(O)=O)=O)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
162453-16QES95478.1M7
2453-15;Malonyl-CoA
from: 2453-15
O=C(/C(C)=C/CC(O)C(C)C(C(CC(C)C)/C=C/C(O)=O)=O)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
172453-17QES95479.1M8
2453-16
from: 2453-16
O=C(/C(C)=C/CC(O)C(C)C(C(CC(C)C)/C=C/C=C/C=C/C(O)=O)=O)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Iteration': [(['DH', 'KR']…
182453-18QES95480.1—
2453-17
from: 2453-17
O=C(C1=C2)C3=C(C(C(/C(C)=C/C[C@@H](O)[C@H](C)C(C(CC(C)C)/C=C/C=C/C=C/C(N1)=O)=O)=O)=C(O)C(C)C3O)C2=O—
192453-19?—
2453-18
from: 2453-18
O=C(C1=C2)C3=C(C(C(/C(C)=C/C[C@@H](O)[C@H](C)C(/C(CC(C)C)=C/C=C/C=C/CC(N1)=O)=O)=O)=C(O)C(C)C3O)C2=O—
202453(1)—
2453-19
from: 2453-19
O=C([C@@]12[C@@]3([H])CC(N2)=O)C4=C(C(C(/C(C)=C/C[C@@H](O)[C@@H]5C)=O)=C(O)C(C)C4O)C([C@]1([H])[C@](C=C3)([H])/C=C(CC(C)C)/C5=O)=O—
212453(2)?—
2453(1)
O=C([C@@]12[C@@]3([H])CC(N2)=O)C4=C(C5=C(O)C(C)C4O)C([C@]1([H])[C@](C=C3)([H])/C=C(CC(C)C)/C([C@@H](C)[C@@H](/C=C/[C@@H](C)C5=O)O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture