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BGC0002452PKS

Leucomycin

Producing organism
Streptomyces kitasatoensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map51 genes · 96,795 bp

20 kb96.8 kb visible · 96,795 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Resistance
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
lcmA1
Step 10
Start
+Mycaminose
Step 11
Start
+Mycarose
Step 2M1
lcmA1
Step 3M2
lcmA1
Step 4M3
lcmA2
Step 5M4
lcmA3
Inactive: KR
Step 6M5
lcmA3
Step 7M6
lcmA4
Step 8M7
lcmA5
Step 9TE
lcmA5
Step 12
lcmBII
Step 13
lcmI
Step 14
?
Step 15
lcmN
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12452-1lcmA1Loading
O=C(C)O—
22452-2lcmA1M1
2452-1
from: 2452-1
C[C@@H](O)CC(O)=O—
32452-3lcmA1M2
2452-2
from: 2452-2
C[C@@H](O)C/C=C/C(O)=O—
42452-4lcmA2M3
2452-3
from: 2452-3
C[C@@H](O)C/C=C/C=C/C(O)=O—
52452-5lcmA3M4
2452-4
from: 2452-4
C[C@@H](O)C/C=C/C=C/C([C@@H](C(O)=O)C)=O{'Inactive': ['KR']}
62452-6lcmA3M5
2452-5
from: 2452-5
C[C@@H](O)C/C=C/C=C/C([C@@H](C[C@@H](C(O)=O)CC)C)=O—
72452-7lcmA4M6
2452-6
from: 2452-6
C[C@@H](O)C/C=C/C=C/C([C@@H](C[C@@H]([C@H](O)[C@H](C(O)=O)OC)CC)C)=O—
82452-8lcmA5M7
2452-7
from: 2452-7
C[C@@H](O)C/C=C/C=C/C([C@@H](C[C@@H]([C@H](O)[C@H]([C@H](O)CC(O)=O)OC)CC)C)=O—
92452-9lcmA5TE
2452-8
from: 2452-8
O=C(/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC)[C@H](O)[C@@H](OC)[C@H](O)CC1=O—
102452-10Start—
Mycaminose
CC1O[C@@H](O)[C@H](O)[C@@H](N(C)C)[C@@H]1O—
112452-11Start—
Mycarose
O[C@@H]1O[C@@H](C)[C@H](O)[C@@](O)(C)C1—
122452-12lcmBII—
2452-9;2452-10
from: 2452-9, 2452-10
O=C(/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
132452-13lcmI—
2452-12
from: 2452-12
O=C(/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CCO)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
142452-14?—
2452-13
from: 2452-13
O=C(/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
152452-15lcmN—
2452-11;2452-14
from: 2452-11, 2452-14
O=C(/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](O)(C)C3)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
162452?—
2452-15
from: 2452-15
OC(/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@@](O)(C)C3)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture