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BGC0002451PKS

Inthomycin B

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
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inthomycin B

Gene Cluster Map11 genes · 65,389 bp

KSAKSKSKSKSAKSKSKSAAKSKS10 kb65.4 kb visible · 65,389 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1Load
QGY73448.1
+N-formylglycine
Step 2M1
QGY73446.1
Trans-AT
Step 3M2
QGY73449.1
Trans-AT
Step 4M3
QGY73449.1
Trans-AT
Step 5M4
QGY73449.1
Trans-AT
Step 6M5
QGY73445.1
Trans-AT
Step 7M6
QGY73445.1
+Glycine
Step 8M7
QGY73445.1
Trans-AT
Step 9M8
QGY73445.1
Trans-AT
Step 10M9
QGY73445.1;QGY73454.1
Step 11M10
QGY73454.1
Trans-AT
Step 12M11
QGY73454.1
Step 13M12
QGY73453.1
+Serine
Step 14
?
Step 15
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12451-1QGY73448.1Loading
N-formylglycine
O=C(NCC(O)=O)[H]—
22451-2QGY73446.1M1
2451-1
from: 2451-1
O=C(NCC(CC(O)=O)=O)[H]{'transAT': ['QGY73444.1', '…
32451-3QGY73449.1M2
2451-2
from: 2451-2
OC(/C=C/CC1=CN=CO1)=O{'transAT': ['QGY73444.1', '…
42451-4QGY73449.1M3
2451-3
from: 2451-3
O=C(O)/C=C\C=C\CC1=CN=CO1{'transAT': ['QGY73444.1', '…
52451-5QGY73449.1M4
2451-4
from: 2451-4
C/C(C(O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['QGY73444.1', '…
62451-6QGY73445.1M5
2451-5
from: 2451-5
C/C(C(O)C(C)(C)C(O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['QGY73444.1', '…
72451-7QGY73445.1M6
2451-6;Glycine
from: 2451-6
C/C(C(O)C(C)(C)C(NCC(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
82451-8QGY73445.1M7
2451-7
from: 2451-7
C/C(C(O)C(C)(C)C(NC/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['QGY73444.1', '…
92451-9QGY73445.1M8
2451-8
from: 2451-8
C/C(C(O)C(C)(C)C(NC/C=C/C(O)CC(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['QGY73444.1', '…
102451-10QGY73445.1;QGY73454.1M9
2451-9
from: 2451-9
C/C(C(O)C(C)(C)C(NC/C=C/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
112451-11QGY73454.1M10
2451-10
from: 2451-10
C/C(C(O)C(C)(C)C(NC/C=C/C=C/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['guaB', '2,3-di…
122451-12QGY73454.1M11
2451-11
from: 2451-11
C/C(C(O)C(C)(C)C(NC/C=C/C=C/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
132451-13QGY73453.1M12
2451-12;Serine
from: 2451-12
C/C(C(O)C(C)(C)C(NC/C=C/C=C/C=C/C(NC(CO)C(O)=O)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
142451-14?—
2451-13
from: 2451-13
C/C(C(O)C(C)(C)C(NC(O)/C=C/C=C/C=C/C(NC(CO)C(O)=O)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
152451?—
2451-14
from: 2451-14
O[C@H](/C(C)=C\C=C\C=C\CC1=CN=CO1)C(C)(C)C(N)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture