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BGC0002446PKS

Ionostatin

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
19
DOI
MIBiG entry
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ionostatin

Gene Cluster Map16 genes · 101,096 bp

20 kb101.1 kb visible · 101,096 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1Load
ionAI
+Malonyl-CoA
Step 2M1
ionAI
+Malonyl-CoA
Step 3M2
ionAI
+Malonyl-CoA
Step 4M3
ionAI
+Methylmalonyl-CoA
Step 5M4
ionAI
+Malonyl-CoA
Step 6M5
ionAI
+Malonyl-CoA
Step 7M6
ionAI
+Methylmalonyl-CoA
Step 8M7
ionAII
+Methylmalonyl-CoA
Step 9M8
ionAIII
+Malonyl-CoA
Step 10M9
ionAIV
+Methylmalonyl-CoA
Step 11M10
ionAIV
+Methylmalonyl-CoA
Step 12M11
ionAV
+Malonyl-CoA
Step 13M12
ionAV
+Methylmalonyl-CoA
Step 14M13
ionAVI
+Methylmalonyl-CoA
Step 15M14
ionAVI
+Methylmalonyl-CoA
Step 16M15
ionAVII
+Methylmalonyl-CoA
Step 17
ionCI
Step 18
ionBI, ionBII
Step 19TE
ionAVII, ionCII
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12446-1ionAILoading
Malonyl-CoA
O=C(O)—
22446-2ionAIM1
2446-1;Malonyl-CoA
from: 2446-1
C/C=C/C(O)=O—
32446-3ionAIM2
2446-2;Malonyl-CoA
from: 2446-2
C/C=C/CCC(O)=O—
42446-4ionAIM3
2446-3;Methylmalonyl-CoA
from: 2446-3
C/C=C/CC/C=C(C)/C(O)=O—
52446-5ionAIM4
2446-4;Malonyl-CoA
from: 2446-4
C/C=C/CC/C=C(C)/CCC(O)=O—
62446-6ionAIM5
2446-5;Malonyl-CoA
from: 2446-5
C/C=C/CC/C=C(C)/CC[C@H](O)CC(O)=O—
72446-7ionAIM6
2446-6;Methylmalonyl-CoA
from: 2446-6
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)C(O)=O—
82446-8ionAIIM7
2446-7;Methylmalonyl-CoA
from: 2446-7
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C(O)=O)C—
92446-9ionAIIIM8
2446-8;Malonyl-CoA
from: 2446-8
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C(O)=O)C—
102446-10ionAIVM9
2446-9;Methylmalonyl-CoA
from: 2446-9
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C(O)=O)C)C—
112446-11ionAIVM10
2446-10;Methylmalonyl-CoA
from: 2446-10
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H](C(O)=O)C)C)C—
122446-12ionAVM11
2446-11;Malonyl-CoA
from: 2446-11
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H]([C@@H](O)CC(O)=O)C)C)C—
132446-13ionAVM12
2446-12;Methylmalonyl-CoA
from: 2446-12
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H]([C@@H](O)CC(C(C(O)=O)C)=O)C)C)C—
142446-14ionAVIM13
2446-13;Methylmalonyl-CoA
from: 2446-13
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H]([C@@H](O)CC(C(C[C@@H](C(O)=O)C)C)=O)C)C)C—
152446-15ionAVIM14
2446-14;Methylmalonyl-CoA
from: 2446-14
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H]([C@@H](O)CC(C(C[C@@H](C[C@@H](C(O)=O)C)C)C)=O)C)C)C—
162446-16ionAVIIM15
2446-15;Methylmalonyl-CoA
from: 2446-15
C/C=C/CC/C=C(C)/CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H]([C@@H](O)CC(C(C[C@@H](C[C@@H](C[C@@H](C(O)=O)C)C)C)C)=O)C)C)C—
172446-17ionCI—
2446-16
from: 2446-16
C[C@@H]1[C@H](O1)CC[C@H]2[C@@](C)(O2)CC[C@H](O)C[C@H](O)[C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H]([C@@H](O)CC(C(C[C@@H](C[C@@H](C[C@@H](C(O)=O)C)C)C)C)=O)C)C)C—
182446-18ionBI, ionBII—
2446-17
from: 2446-17
O[C@H]([C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H]([C@@H](O)CC(C(C[C@@H](C[C@@H](C[C@@H](C(O)=O)C)C)C)C)=O)C)C)C)C[C@H]1O[C@@]([C@H]2O[C@@H]([C@H](O)C)CC2)(C)CC1—
192446ionAVII, ionCIITE
2446-18
from: 2446-18
O[C@H]([C@H](C)[C@H](O)[C@@H](/C=C/C[C@H](C[C@H](/C(O)=C/C([C@H](C[C@@H](C[C@@H](C[C@@H](C(O)=O)C)C)C)C)=O)C)C)C)C[C@H]1O[C@@]([C@H]2O[C@@H]([C@H](O)C)CC2)(C)CC1—
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