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BGC0002443PKS

Mycemycin C;Mycemycin A;Mycemycin B

Producing organism
Streptomyces olivaceus
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map23 genes · 32,300 bp

AAmT5 kb32.3 kb visible · 32,300 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
AAdenylation (A)
ACPAcyl carrier (ACP)
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

18 steps · 18 edges
Step 1
Start
+Tryptophan
Step 6
Start
+Chorismic acid
Step 2
mymM, mymC
Step 7
mymA
Step 12
mymC
Step 3
mymD
Step 8
mymE;mymF
Step 13
mymD
Step 4
mymQ
Step 14
mymQ
Step 5
mymB
Step 15
mymG
Step 9
mymG
Step 16
?
Step 10
?
Step 17
mymJ
Step 18
mymJ, mymP
Step 11
mymJ, mymP
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12443-1Start
Tryptophan
NC(C(O)=O)CC1=CNC2=CC=CC=C21
22443-2mymM, mymC
2443-1
from: 2443-1
O=C(CC(C(O)=O)N)C1=CC(Cl)=CC=C1NC=O
32443-3mymD
2443-2
from: 2443-2
NC1=CC=C(Cl)C=C1C(CC(C(O)=O)N)=O
42443-4mymQ
2443-3
from: 2443-3
NC1=CC=C(Cl)C=C1C(O)=O
52443-5mymB
2443-4
from: 2443-4
NC1=CC=C(Cl)C(C)=C1C(O)=O
62443-6Start
Chorismic acid
O=C(O)C1=C[C@@H](OC(C(O)=O)=C)[C@H](O)C=C1
72443-7mymA
2443-6
from: 2443-6
O=C(O)C1=C(O)C=CC=C1
82443-8mymE;mymF
2443-7
from: 2443-7
O=C(O)C1=C(O)C=CC=C1
92443-9mymG
2443-5;2443-8
from: 2443-5, 2443-8
O=C(O)C1=C(C)C(Cl)=CC=C1NC(C2=C(O)C=CC=C2)=O
102443-10?
2443-9
from: 2443-9
O=C(O)C1=C(C)C(Cl)=CC(O2)=C1NC(C3=C2C=CC=C3)=O
112443(1)mymJ, mymP
2443-10
from: 2443-10
O=C(OC)C1=C(C)C(Cl)=CC(O2)=C1NC(C3=C2C=CC(Cl)=C3)=O
122443-11mymC
2443-1
from: 2443-1
O=C(CC(C(O)=O)N)C1=CC=CC=C1NC=O
132443-12mymD
2443-11
from: 2443-11
NC1=CC=CC=C1C(CC(C(O)=O)N)=O
142443-13mymQ
2443-12
from: 2443-12
NC1=C(C(O)=O)C=CC=C1
152443-14mymG
2443-8;2443-13
from: 2443-8, 2443-13
O=C(O)C1=CC=CC=C1NC(C2=C(O)C=CC=C2)=O
162443-15?
2443-14
from: 2443-14
O=C(O)C1=CC=CC2=C1NC(C3=C(O2)C=CC=C3)=O
172443(2)mymJ
2443-15
from: 2443-15
O=C(OC)C1=CC=CC2=C1NC(C3=C(O2)C=CC=C3)=O
182443(3)mymJ, mymP
2443-15
from: 2443-15
O=C(OC)C1=CC=CC2=C1NC(C3=C(O2)C=CC(Cl)=C3)=O
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