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BGC0002440NRPS

Longicatenamide B;Longicatenamide C;Longicatenamide A;Longicatenamide D

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map26 genes · 50,466 bp

AmTAmTTauDCACACAECAECACAETauD10 kb50.5 kb visible · 50,466 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
EEpimerization (E)
AmTAminotransferase I/II
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
+L-Leucine
Step 7
Start
+Arginine
Step 10M1
QUJ09166.1
+Glycine
Step 2
?
Step 8
QUJ09169.1
Step 3
QUJ09159.1/QUJ09154.1
+Acetyl-CoA
Step 9
QUJ09169.1
Step 4
QUJ09160.1, QUJ09161.1
Step 5
?
Step 6
QUJ09162.1?
Step 11M2
QUJ09166.1
Step 12M3
QUJ09167.1
+(D-Leucine/L-Leuc…
Step 13M4
QUJ09167.1
Step 14M5
QUJ09167.1
+Glutamic acid
Step 15
QUJ09163.1/QUJ09170.1?
Step 16M6
QUJ09168.1
+Tryptophan
Step 17M6
QUJ09168.1
+Tryptophan
Step 18
QUJ09165.1
Step 19
QUJ09165.1
Step 20
QUJ09165.1
Step 21
QUJ09165.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12440-1Start—
L-Leucine
CC(CC(N)C(O)=O)C—
22440-2?—
2440-1
from: 2440-1
CC(CC(C(O)=O)=O)C—
32440-3QUJ09159.1/QUJ09154.1—
2440-2;Acetyl-CoA
from: 2440-2
O=C(C(O)=O)CCC(C)C—
42440-4QUJ09160.1, QUJ09161.1—
2440-3
from: 2440-3
OC([C@@](O)(CCC(C)C)CC(O)=O)=O—
52440-5?—
2440-4
from: 2440-4
O=C(O)[C@H]([C@H](C(O)=O)O)CCC(C)C—
62440-6QUJ09162.1?—
2440-5
from: 2440-5
O=C(C(CCCC(C)C)=O)O—
72440-7Start—
Arginine
O=C([C@@H](N)CCCNC(N)=N)O—
82440-8QUJ09169.1—
2440-7
from: 2440-7
O=C([C@@H](N)CCCNC(N)=O)O—
92440-9QUJ09169.1—
2440-8
from: 2440-8
O=C([C@@H](N)CCCN)O—
102440-10QUJ09166.1M1
Glycine
OC(CN)=O—
112440-11QUJ09166.1M2
2440-10;2440-6
from: 2440-10, 2440-6
OC([C@H](CCCC(C)C)NC(CN)=O)=O—
122440-12QUJ09167.1M3
2440-11;(D-Leucine/L-Leucine)
from: 2440-11
OC(C(C(C)C)NC([C@H](CCCC(C)C)NC(CN)=O)=O)=O—
132440-13QUJ09167.1M4
2440-12;2440-9
from: 2440-12, 2440-9
OC([C@@H](CCCN)NC(C(C(C)C)NC([C@H](CCCC(C)C)NC(CN)=O)=O)=O)=O—
142440-14QUJ09167.1M5
2440-13;Glutamic acid
from: 2440-13
OC([C@H](CCC(O)=O)NC([C@@H](CCCN)NC(C(C(C)C)NC([C@H](CCCC(C)C)NC(CN)=O)=O)=O)=O)=O—
152440-15QUJ09163.1/QUJ09170.1?—
2440-14
from: 2440-14
OC([C@H]([C@@H](CC(O)=O)O)NC([C@@H](CCCN)NC(C(C(C)C)NC([C@H](CCCC(C)C)NC(CN)=O)=O)=O)=O)=O—
162440-16QUJ09168.1M6
2440-14;Tryptophan
from: 2440-14
O=C(O)[C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCC(O)=O)NC([C@@H](CCCN)NC(C(C(C)C)NC([C@H](CCCC(C)C)NC(CN)=O)=O)=O)=O)=O—
172440-17QUJ09168.1M6
2440-15;Tryptophan
from: 2440-15
O=C(O)[C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H]([C@@H](CC(O)=O)O)NC([C@@H](CCCN)NC(C(C(C)C)NC([C@H](CCCC(C)C)NC(CN)=O)=O)=O)=O)=O—
182440(1)QUJ09165.1—
2440-16
from: 2440-16
O=C([C@@H](CCCN)N1)N[C@@H](C([H])CC(O)=O)C(N[C@H](CC2=CNC3=C2C=CC=C3)C(NCC(N[C@@H](CCCC(C)C)C(N[C@H](C(C)C)C1=O)=O)=O)=O)=O—
192440(2)QUJ09165.1—
2440-16
from: 2440-16
O=C([C@@H](CCCN)N1)N[C@@H](C([H])CC(O)=O)C(N[C@H](CC2=CNC3=C2C=CC=C3)C(NCC(N[C@@H](CCCC(C)C)C(N[C@@H](C(C)C)C1=O)=O)=O)=O)=O—
202440(3)QUJ09165.1—
2440-17
from: 2440-17
O=C([C@@H](CCCN)N1)N[C@@H]([C@H](O)CC(O)=O)C(N[C@H](CC2=CNC3=C2C=CC=C3)C(NCC(N[C@@H](CCCC(C)C)C(N[C@H](C(C)C)C1=O)=O)=O)=O)=O—
212440(4)QUJ09165.1—
2440-17
from: 2440-17
O=C([C@@H](CCCN)N1)N[C@@H]([C@H](O)CC(O)=O)C(N[C@H](CC2=CNC3=C2C=CC=C3)C(NCC(N[C@@H](CCCC(C)C)C(N[C@@H](C(C)C)C1=O)=O)=O)=O)=O—
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