NPdia
← Back to Repository
BGC0002434Hybrid

Clifednamide D;Clifednamide E;Clifednamide F;Clifednamide G;Clifednamide H;Clifednamide I;Clifednamide J

Producing organism
Kitasatospora sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Kitasatospora
Biosynthetic class
PKS (Unknown);NRPS (Type I)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
Loading…

Gene Cluster Map9 genes · 19,176 bp

KSATDHKRCATEER5 kb19.2 kb visible · 19,176 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1
cftB
Iterative
Step 3
cftB
Iterative
Step 2
cftB
+Lysine
Step 4
cftB
Step 5TE
cftB
Step 6
cftC
Step 7
cftC/Spontaneous
Step 8
?
Step 9
cftA
Step 10
cftE
Step 11
cftA
Step 12
?
+2434(3)
Step 13
cftE
+2434(3)
Step 14
cftA
+2434(3)
Step 16
cftD
+2434(3)
Step 15
cftE, cftD
Step 17
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12434-1cftB—
C/C=C/C=C/C=C/C=C/C(CC(O)=O)=O{'Iteration': [(['None'], 'M…
22434-2cftB—
2434-1;Lysine
from: 2434-1
C/C=C/C=C/C=C/C=C/C(CC(N[C@@H](CCCN)C(O)=O)=O)=O—
32434-3cftB—
C/C=C/C=C/C=C/C=C/C=C/C(O)=O{'Iteration': [(['None'], 'M…
42434-4cftB—
2434-2;2434-3
from: 2434-2, 2434-3
C/C=C/C=C/C=C/C=C/C(CC(N[C@@H](CCCNC(/C=C/C=C/C=C/C=C/C=C/C)=O)C(O)=O)=O)=O—
52434-5cftBTE
2434-4
from: 2434-4
C/C=C/C=C/C=C/C=C/C(C1=C(O)[C@@](CCCNC(/C=C/C=C/C=C/C=C/C=C/C)=O)([H])NC1=O)=O—
62434-6cftC—
2434-5
from: 2434-5
CC[C@H]([C@H](C)CC([H])C([H])/C=C/C=C/C(C1=C2O)=O)C([H])CCC([H])/C=C/C=C/C(NCCC[C@H]2NC1=O)=O—
72434-7cftC/Spontaneous—
2434-6
from: 2434-6
CC[C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(NCCC[C@]3([H])NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]2([H])C[C@H]1C—
82434(1)?—
2434-7
from: 2434-7
CC[C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(N)=O)([H])[C@@](/C=C/C=C/C(C3=C(O)[C@@](CCC(O)=O)([H])NC3=O)=O)([H])[C@@]2([H])C[C@H]1C—
92434-8cftA—
2434-7
from: 2434-7
C[C@H](O)[C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(NCCC[C@]3([H])NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]2([H])C[C@H]1C—
102434(2)cftE—
2434-8
from: 2434-8
CC(O)[C@@]1([H])[C@]2([H])C=C[C@@](/C=C/C=C/C(NCC[C@H](O)[C@]3([H])NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]2([H])C[C@H]1C—
112434(3)cftA—
2434-8
from: 2434-8
CC([C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(NCCC[C@]3([H])NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]2([H])C[C@H]1C)=O—
122434(4)?—
2434(3)
CC([C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(N)=O)([H])[C@@](/C=C/C=C/C(C3=C(O)[C@@](CCC(O)=O)([H])NC3=O)=O)([H])[C@@]2([H])C[C@H]1C)=O—
132434(5)cftE—
2434(3)
CC([C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(NCC[C@H](O)[C@]3([H])NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]2([H])C[C@H]1C)=O—
142434-9cftA—
2434(3)
[H][C@@]12C=C[C@@](/C=C/C=C/C(NCCC[C@]3([H])NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]1([H])C[C@@H](C)[C@H]2C(CO)=O—
152434(6)cftE, cftD—
2434-9
from: 2434-9
[H][C@@]12C=C[C@@](/C=C/C=C/C(NCC[C@H](O)[C@]3([H])NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]1([H])C[C@@H](C)[C@H]2C(CO)=O—
162434-10cftD—
2434(3)
CC([C@H]1[C@]2([H])C=C[C@@]3([H])[C@@](C[C@@H]4[C@@H]3C/C=C\C(NCCC[C@]5([H])NC(C(C(/C=C/4)=O)=C5O)=O)=O)([H])[C@@]2([H])C[C@H]1C)=O—
172434(7)?—
2434-10
from: 2434-10
CC([C@H]1[C@]2([H])C=C[C@@]3([H])[C@@](C[C@@H](/C=C/C(C4=C(O)[C@@](CCC(O)=O)([H])NC4=O)=O)[C@@H]3C/C=C\C(N)=O)([H])[C@@]2([H])C[C@H]1C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture