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BGC0002431PKS

Maduramicin

Producing organism
Actinomadura sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinomadura
Biosynthetic class
PKS (Unknown);saccharide (None)
Total steps
27
DOI
MIBiG entry
View on MIBiG ↗
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maduramicin

Gene Cluster Map38 genes · 121,610 bp

20 kb121.6 kb visible · 121,610 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

27 steps · 26 edges
Step 1Load
madA1
+Malonyl-CoA
Step 18
Start
+Glucose
Step 2M1
madA1
+Methylmalonyl-CoA
Inactive: DH
Step 19
madG1
Step 3M2
madA2
+Methylmalonyl-CoA
Step 20
madG2
Step 4M3
madA3
+Malonyl-CoA
Step 21
madG3
Step 5M4
madA3
+Malonyl-CoA
Step 22
madG4
Step 6M5
madA4
+Methylmalonyl-CoA
Step 23
madG5, madG6
Step 7M6
madA4
+Malonyl-CoA
Step 24
madG7
Step 8M7
madA5
+Methylmalonyl-CoA
Step 25
madG8
Step 9M8
madA5
+Malonyl-CoA
Step 10M9
madA6
+Malonyl-CoA
Inactive: KR
Step 11M10
madA7
+Methylmalonyl-CoA
Step 12M11
madA7
+Methylmalonyl-CoA
Step 13M12
madA7
+Malonyl-CoA
Step 14M13
madA8
+Methylmalonyl-CoA
Inactive: DH
Step 15M14
madA9
+Malonyl-CoA
Inactive: DH, KR
Step 16M15, 16
(madA10;madA11), madO, …
Inactive: KS, AT
Step 17
madP1/madP2
Step 26
madG9/madG10
Step 27
madE
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions27 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12431-1madA1Loading
Malonyl-CoA
O=C(C)O—
22431-2madA1M1
2431-1;Methylmalonyl-CoA
from: 2431-1
O=C(C)C(C(O)=O)C{'Inactive': ['DH']}
32431-3madA2M2
2431-2;Methylmalonyl-CoA
from: 2431-2
O=C(C)C(CC(C(O)=O)C)C—
42431-4madA3M3
2431-3;Malonyl-CoA
from: 2431-3
O=C(C)C(CC(/C=C/C(O)=O)C)C—
52431-5madA3M4
2431-4;Malonyl-CoA
from: 2431-4
O=C(C)C(CC(/C=C/CCC(O)=O)C)C—
62431-6madA4M5
2431-5;Methylmalonyl-CoA
from: 2431-5
O=C(C)C(CC(/C=C/CC/C=C(C)/C(O)=O)C)C—
72431-7madA4M6
2431-6;Malonyl-CoA
from: 2431-6
O=C(C)C(CC(/C=C/CC/C=C(C)/CCC(O)=O)C)C—
82431-8madA5M7
2431-7;Methylmalonyl-CoA
from: 2431-7
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/C(O)=O)C)C—
92431-9madA5M8
2431-8;Malonyl-CoA
from: 2431-8
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/CCC(O)=O)C)C—
102431-10madA6M9
2431-9;Malonyl-CoA
from: 2431-9
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/CCC(CC(O)=O)=O)C)C{'Inactive': ['KR']}
112431-11madA7M10
2431-10;Methylmalonyl-CoA
from: 2431-10
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/CCC(CC(O)C(C)C(O)=O)=O)C)C—
122431-12madA7M11
2431-11;Methylmalonyl-CoA
from: 2431-11
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/CCC(CC(O)C(C)C(O)C(C)C(O)=O)=O)C)C—
132431-13madA7M12
2431-12;Malonyl-CoA
from: 2431-12
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/CCC(CC(O)C(C)C(O)C(C)C(O)CC(O)=O)=O)C)C—
142431-14madA8M13
2431-13;Methylmalonyl-CoA
from: 2431-13
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/CCC(CC(O)C(C)C(O)C(C)C(O)CC(O)C(C)C(O)=O)=O)C)C{'Inactive': ['DH']}
152431-15madA9M14
2431-14;Malonyl-CoA
from: 2431-14
O=C(C)C(CC(/C=C/CC/C=C(C)/CC/C=C(C)/CCC(CC(O)C(C)C(O)C(C)C(O)CC(O)C(C)C(CC(O)=O)=O)=O)C)C{'Inactive': ['DH', 'KR']}
162431-16(madA10;madA11), madO, madIM15, 16
2431-15
from: 2431-15
OC(CC1(O)OC(C(C)C2OC(OC3(C)C4OC(C5OC(C6C(C)CC(C)C(C)(O)O6)CC5)(C)CC4)(CC3)CC(O)C2C)CC(O)C1C)=O{'Inactive': ['KS', 'AT']}
172431-17madP1/madP2—
2431-16
from: 2431-16
OC(CC1(O)OC(C(C)C2OC(OC3(C)C4OC(C5OC(C6C(C)CC(C)C(C)(O)O6)CC5O)(C)CC4)(CC3)CC(O)C2C)C(OC)C(OC)C1C)=O—
182431-18Start—
Glucose
OCC1C(O)C(O)C(O)C(OP(O)(O)=O)O1—
192431-19madG1—
2431-18
from: 2431-18
[R]C(O1)C(O)C(O)C(O)C1CO—
202431-20madG2—
2431-19
from: 2431-19
CC1C(C(O)C(O)C([R])O1)=O—
212431-21madG3—
2431-20
from: 2431-20
CC1C(C(CC([R])O1)=O)=O—
222431-22madG4—
2431-21
from: 2431-21
CC1C(C(O)CC([R])O1)=O—
232431-23madG5, madG6—
2431-22
from: 2431-22
CC1C(C(OC)CC([R])O1)=O—
242431-24madG7—
2431-23
from: 2431-23
CC1C(O)C(OC)CC([R])O1—
252431-25madG8—
2431-24
from: 2431-24
CC1C(OC)C(OC)CC([R])O1—
262431-26madG9/madG10—
2431-17;2431-25
from: 2431-17, 2431-25
OC(CC1(O)OC(C(C)C2OC(OC3(C)C4OC(C5OC(C6C(C)CC(C)C(C)(O)O6)CC5OC(CC7OC)OC(C)C7OC)(C)CC4)(CC3)CC(O)C2C)C(OC)C(OC)C1C)=O—
272431madE—
2431-26
from: 2431-26
OC(CC1(O)OC(C(C)C2OC(OC3(C)C4OC(C5OC(C6C(C)CC(C)C(C)(O)O6)CC5OC(CC7OC)OC(C)C7OC)(C)CC4)(CC3)CC(O)C2C)C(OC)C(OC)C1C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture