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BGC0002426NRPS

Deschlorosvetamycin A;Svetamycin H;Svetamycin A

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map47 genes · 52,935 bp

KSKS10 kb52.9 kb visible · 52,935 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
MTMethyltransferase
CycPolyketide cyclase

Pathway Graphsteps arranged in biosynthetic order

21 steps · 22 edges
Step 1
Start
+Glycine
Step 3
?
+D-alanine
Step 6
?
+D-xylulose-5-phos…
Step 8
Start
+L-arginine
Step 2
?
Step 9
?
Step 4
?
Step 10
?
Step 5M1
?
Step 11
?
Step 7M2
?
Step 12
?
Step 13
?
Step 14M3
?
Step 15M4
?
Step 16M5
?
+(2426-12/2426-13)
Step 17M6
?
Step 18TE
?
Step 19TE
?
Step 20TE
?
Step 21TE
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12426-1Start—
Glycine
O=C(O)CN—
22426-2?—
2426-1
from: 2426-1
O=C(O)[C@H](CO)N—
32426-3?—
D-alanine
O=C(O)[C@@H](C)N—
42426-4?—
2426-2;2426-3
from: 2426-2, 2426-3
O=C(O)[C@@](C)(N)CO—
52426-5?M1
2426-4
from: 2426-4
O=C(O)[C@@](C)(N)CO—
62426-6?—
D-xylulose-5-phosphate
O=C(O)CO—
72426-7?M2
2426-5;2426-6
from: 2426-5, 2426-6
O=C(OCC(O)=O)[C@@](C)(N)CO—
82426-8Start—
L-arginine
O=C([C@@H](N)CCCNC(N)=N)O—
92426-9?—
2426-8
from: 2426-8
O=C([C@@H](N)CCCN)O—
102426-10?—
2426-9
from: 2426-9
O=C([C@@H](N)CCCNO)O—
112426-11?—
2426-10
from: 2426-10
O=C([C@@H]1CCC=NN1)O—
122426-12?—
2426-11
from: 2426-11
O=C([C@@H]1CCCNN1)O—
132426-13?—
2426-12
from: 2426-12
O=C([C@@H]1C[C@H](Cl)CNN1)O—
142426-14?M3
2426-7;2426-11
from: 2426-7, 2426-11
O=C(OCC(N1N=CCC[C@@H]1C(O)=O)=O)[C@@](C)(N)CO—
152426-15?M4
2426-14;2426-11
from: 2426-14, 2426-11
O=C(OCC(N1[C@@H](C(N[C@H](C(O)=O)C)=O)CCC=N1)=O)[C@@](C)(N)CO—
162426-16?M5
2426-15;(2426-12/2426-13)
from: 2426-15
O=C([C@](N)(C)CO)OCC(N1[C@@H](C(N[C@@H](C)C(N2NC[C@@H]([R])C[C@@H]2C(O)=O)=O)=O)CCC=N1)=O—
172426-17?M6
2426-16;2426-12
from: 2426-16, 2426-12
O=C([C@@H](C1)N(C([C@@H](NC([C@H]2CCC=NN2C(COC([C@@](N)(CO)C)=O)=O)=O)C)=O)NC[C@H]1[R])N3[C@H](C(O)=O)CCCN3—
182426-18?TE
2426-17
from: 2426-17
O=C(N(N=C[C@H](O)[C@@H]1O)[C@H]1C(N[C@@H](C)C(N(NC[C@@H]([R])C2)[C@H]2C(N3[C@H]4CCCN3)=O)=O)=O)COC([C@](C)(CO)NC4=O)=O—
192426(1)?TE
2426-17
from: 2426-17
O=C(N(N=C[C@H](O)[C@@H]1O)[C@H]1C(N[C@@H](C)C(N(NCC([H])C2)[C@H]2C(N3[C@H]4CCCN3)=O)=O)=O)COC([C@](C)(CO)NC4=O)=O—
202426(2)?TE
2426-17
from: 2426-17
O=C(N(N=C[C@H](O)[C@@H]1O)[C@H]1C(N[C@@H](C)C(N(NC[C@@H](Cl)C2)[C@H]2C(N3[C@H]4CCCN3)=O)=O)=O)COC([C@](C)(CO)NC4=O)=O—
212426(3)?TE
2426-17
from: 2426-17
O=C(N(N=C[C@H](O)[C@@H]1O)[C@H]1C(N[C@@H](C)C(N(NC[C@@H](Cl)C2)[C@H]2C(N(NCCC3)[C@@H]3C(N[C@@](C)(CO)C(O)=O)=O)=O)=O)=O)CO—
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