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BGC0002385PKS

dumulmycin

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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dumulmycin
C33H48O8572.33 Da

Gene Cluster Map21 genes · 87,287 bp

KSKSKSKSKSKSKSKSKSKSKSKSKSKSKS20 kb87.3 kb visible · 87,287 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
ECHEnoyl-CoA hydratase
MTMethyltransferase
ACPβACP (β-branching)
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
sdlD
Trans-AT
Step 2M1
sdlD
Trans-AT
Step 3M2
sdlD
Trans-AT
Step 4M3
sdlD,sdlI
Trans-AT
Step 5M4
sdlD
Trans-AT
Step 6M5
sdlD;sdlE
Trans-AT
Step 7M6
sdlE
Trans-AT
Step 8M7
sdlE
Trans-AT
Step 9M8
sdlE
Module Skip
Step 10M9
sdlF
Trans-AT
Step 11M10
sdlF
Trans-AT
Step 12M11
sdlF;sdlG
Trans-AT
Step 13M12
sdlG
Trans-AT
Step 14M13
sdlG;sdlH
Trans-AT
Step 15M14
sdlH
Trans-AT
Step 16TE
sdlH
Step 17
sdlB,sdlQ
Step 18
sdlR
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12385-1sdlDLoading
OC(C)=O{'transAT': ['sdlJ', 'Malony…
22385-2sdlDM1
2385-1
from: 2385-1
OC(CCC)=O{'transAT': ['sdlJ', 'Malony…
32385-3sdlDM2
2385-2
from: 2385-2
OC(C[C@@H](O)CCC)=O{'transAT': ['sdlJ', 'Malony…
42385-4sdlD,sdlIM3
2385-3
from: 2385-3
OC(C(C)CC[C@@H](O)CCC)=O{'transAT': ['sdlJ', 'Malony…
52385-5sdlDM4
2385-4
from: 2385-4
OC(C(C)[C@H](O)C(C)CC[C@@H](O)CCC)=O{'transAT': ['sdlJ', 'Malony…
62385-6sdlD;sdlEM5
2385-5
from: 2385-5
OC(C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)=O{'transAT': ['sdlJ', 'Malony…
72385-7sdlEM6
2385-6
from: 2385-6
OC(/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)=O{'transAT': ['sdlJ', 'Malony…
82385-8sdlEM7
2385-7
from: 2385-7
OC(/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)=O{'transAT': ['sdlJ', 'Malony…
92385-9sdlEM8
2385-8
from: 2385-8
OC(/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)=O{‘ModuleSkip’: ‘Skip'}
102385-10sdlFM9
2385-9
from: 2385-9
OC(C[C@@H](O)/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)=O{'transAT': ['sdlJ', 'Malony…
112385-11sdlFM10
2385-10
from: 2385-10
OC(/C=C(C[C@@H](O)/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)\C)=O{'transAT': ['sdlJ', 'Malony…
122385-12sdlF;sdlGM11
2385-11
from: 2385-11
OC(/C=C/C=C(C[C@@H](O)/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)\C)=O{'transAT': ['sdlJ', 'Malony…
132385-13sdlGM12
2385-12
from: 2385-12
OC(/C=C(C)/C=C/C=C(C[C@@H](O)/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)\C)=O{'transAT': ['sdlJ', 'Malony…
142385-14sdlG;sdlHM13
2385-13
from: 2385-13
OC(C(C)[C@H](O)/C=C(C)/C=C/C=C(C[C@@H](O)/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)\C)=O{'transAT': ['sdlJ', 'Malony…
152385-15sdlHM14
2385-14
from: 2385-14
O=C(O)C/C=C(C)/[C@H](O)/C=C(C)/C=C/C=C(C[C@@H](O)/C=C/C=C/C[C@H](O)C(C)[C@H](O)C(C)CC[C@@H](O)CCC)\C{'transAT': ['sdlJ', 'Malony…
162385-16sdlHTE
2385-15
from: 2385-15
C/C([C@H](O)/C=C/C=C/C=C(C[C@@H](O)/C=C/C=C/C[C@@H]1O)\C)=C\CC(O[C@H]([C@@H](CC[C@H](O)CCC)C)[C@H]1C)=O—
172385-17sdlB,sdlQ—
2385-16
from: 2385-16
C/C([C@H](O)/C=C(C)/C=C/C=C(C([C@@H](O)/C=C/C=C/C[C@@H]1O)=O)\C)=C\CC(O[C@H]([C@@H](CCC(CCC)=O)C)[C@H]1C)=O—
182385sdlR—
2385-17
from: 2385-17
C[C@@H]([C@@H](OC1=O)[C@@H](C)[C@H](C[C@@H](O)/C=C\[C@@H](C(C(O)=C2C)=O)[C@H]2/C=C/C(C)=C/[C@@H](O)/C(C)=C/C1)O)CCC(CCC)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture