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BGC0002378NRPS

coprisamide C;coprisamide D

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map23 genes · 41,818 bp

CAECAECAECACACAKSKSKSTE10 kb41.8 kb visible · 41,818 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1
Start
+O-phospho-L-Serine
Step 4
Start
+L-Glutamic acid
Step 6
?
+?
Step 2
?
Step 5
?
Step 7M1
copA
+D-Alanine
Step 3
?
Step 8M2
copA
+D-Serine
Step 9M3
copB
+D-Leucine
Step 10M4
copB
+L-Valine
Step 11M5
copB
Step 12M6
copB
Step 13TE
copB
Step 14
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12378-1Start—
O-phospho-L-Serine
O=C(O)[C@H](COP(O)(O)=O)N—
22378-2?—
2378-1
from: 2378-1
O=C(O)[C@H](CN)N—
32378-3?—
2378-2
from: 2378-2
O=C(O)[C@H](CNC([C@@H](N)C(C)C)=O)N—
42378-4Start—
L-Glutamic acid
O=C(O)[C@@H](N)CCC(O)=O—
52378-5?—
2378-4
from: 2378-4
O=C([C@@H](C)[C@H](N)C(O)=O)O—
62378-6?—
?
OC(/C=C/C1=CC=CC=C1/C=C\C=C\CC(C)C)=O—
72378-7copAM1
2378-6;D-Alanine
from: 2378-6
OC([C@@H](C)NC(/C=C/C1=CC=CC=C1/C=C\C=C\CC(C)C)=O)=O—
82378-8copAM2
2378-7;D-Serine
from: 2378-7
OC([C@@H](CO)NC([C@@H](C)NC(/C=C/C1=CC=CC=C1/C=C\C=C\CC(C)C)=O)=O)=O—
92378-9copBM3
2378-8;D-Leucine
from: 2378-8
OC([C@@H](CC(C)C)NC([C@@H](CO)NC([C@@H](C)NC(/C=C/C1=CC=CC=C1/C=C\C=C\CC(C)C)=O)=O)=O)=O—
102378-10copBM4
2378-9;L-Valine
from: 2378-9
OC([C@@H](NC([C@@H](CC(C)C)NC([C@@H](CO)NC([C@@H](C)NC(/C=C/C1=CC=CC=C1/C=C\C=C\CC(C)C)=O)=O)=O)=O)C(C)C)=O—
112378-11copBM5
2378-10;2378-3
from: 2378-10, 2378-3
OC([C@@H](NC([C@@H](NC([C@@H](CC(C)C)NC([C@@H](CO)NC([C@@H](C)NC(/C=C/C1=CC=CC=C1/C=C\C=C\CC(C)C)=O)=O)=O)=O)C(C)C)=O)CNC([C@@H](N)C(C)C)=O)=O—
122378-12copBM6
2378-11;2378-5
from: 2378-11, 2378-5
O=C(O)[C@@H](C)[C@H](NC([C@@H](NC([C@@H](NC([C@@H](CC(C)C)NC([C@@H](CO)NC([C@@H](C)NC(/C=C/C1=CC=CC=C1/C=C\C=C\CC(C)C)=O)=O)=O)=O)C(C)C)=O)CNC([C@@H](N)C(C)C)=O)=O)C(O)=O—
132378(1)copBTE
2378-12
from: 2378-12
O=C(O)[C@@H](C)[C@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N1)=O)C(C)C)=O)CNC([C@@H](N)C(C)C)=O)=O)C(OC[C@H](NC([C@H](C)NC(/C=C/C2=CC=CC=C2/C=C\C=C\CC(C)C)=O)=O)C1=O)=O—
142378(2)—
2378-12
from: 2378-12
O=C([C@H]([C@@H](C(OC[C@@H]1NC([C@@H](NC(/C=C/C2=CC=CC=C2/C=C/C=C/CC(C)C)=O)C)=O)=O)NC([C@H](CNC([C@H](C(C)C)N)=O)NC([C@H](C(C)C)NC([C@@H](NC1=O)CC(C)C)=O)=O)=O)C)O—
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