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BGC0002377NRPS

WS9326B;WS9326A;WS9326G;WS9326F

Producing organism
Streptomyces sp. SNM55
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
20
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map40 genes · 58,067 bp

KSCACACACAECCACAAAKS10 kb58.1 kb visible · 58,067 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

20 steps · 19 edges
Step 1
start
Step 2M1
QBA57735.1
+(Threonine/Serine)
Step 3M2
QBA57735.1
+(E)-2,3-didehy-dr…
Step 10M2
QBA57735.1
+(E)-2,3-didehy-dr…
Step 4M3
QBA57736.1
+Leucine
Step 11M3
QBA57736.1
+Leucine
Step 5M4
QBA57736.1
+Phenylalanine
Step 12M4
QBA57736.1
+Phenylalanine
Step 6M5,6,7
QBA57731.1,QBA57738.1,Q…
+Threonine, Asparagine
Step 13M5,6,7
QBA57731.1,QBA57738.1,Q…
Step 7M7*
QBA57737.1
Module Skip
Step 14M7*
QBA57737.1
+Serine
Step 8M8
QBA57737.1
+Serine
Step 15M8
QBA57737.1
+(E)-2,3-didehy-dr…
Step 9TE
QBA57737.1
Step 16
?
Step 19TE
QBA57737.1
Step 20TE
QBA57737.1
Step 17
?
Step 18
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions20 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12377-1start—
OC(/C=C/C1=CC=CC=C1/C=C\CCC)=O—
22377-2QBA57735.1M1
2377-1;(Threonine/Serine)
from: 2377-1
OC([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@H](O)[R])=O—
32377-3QBA57735.1M2
2377-2;(E)-2,3-didehy-drotyrosine
from: 2377-2
OC(C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@H](O)C)=O)C)CC2=CC=C(O)C=C2)=O—
42377-4QBA57736.1M3
2377-3;Leucine
from: 2377-3
OC([C@@H](NC(C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@H](O)C)=O)C)CC2=CC=C(O)C=C2)=O)CC(C)C)=O—
52377-5QBA57736.1M4
2377-4;Phenylalanine
from: 2377-4
O=C([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)C)=O)C)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)O—
62377-6QBA57731.1,QBA57738.1,QBA57740.1,QBA57741.1,QBA57737.1M5,6,7
2377-5;Threonine;Asparagine
from: 2377-5
O=C(N)CC(NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)C)=O)C)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)=O)C(O)=O—
72377-7QBA57737.1M7*
2377-6
from: 2377-6
O=C(N)CC(NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)C)=O)C)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)=O)C(O)=O{‘ModuleSkip’: ‘Skip'}
82377-8QBA57737.1M8
2377-7;Serine
from: 2377-7
OC([C@@H](NC(C(NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)C)=O)C)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)=O)CC(N)=O)=O)CO)=O—
92377(1)QBA57737.1TE
2377-8
from: 2377-8
O=C([C@@H](N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@@H](C)OC2=O)=O)C)CC3=CC=C(O)C=C3)N[C@@H](CC(C)C)C(N[C@H](CC4=CC=CC=C4)C(N[C@H](C(NC(C(N[C@H]2CO)=O)CC(N)=O)=O)[C@@H](O)C)=O)=O—
102377-9QBA57735.1M2
2377-2;(E)-2,3-didehy-drotyrosine
from: 2377-2
OC(/C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@H](O)[R])=O)C)=C\C2=CC=C(O)C=C2)=O—
112377-10QBA57736.1M3
2377-9;Leucine
from: 2377-9
OC([C@@H](NC(/C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@H](O)[R])=O)C)=C\C2=CC=C(O)C=C2)=O)CC(C)C)=O—
122377-11QBA57736.1M4
2377-10;Phenylalanine
from: 2377-10
O=C([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(/C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)[R])=O)C)=C\C3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)O—
132377-12QBA57731.1,QBA57738.1,QBA57740.1,QBA57741.1,QBA57737.1M5,6,7
2377-11
from: 2377-11
O=C(N)CC(NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(/C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)[R])=O)C)=C\C3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)=O)C(O)=O—
142377-13QBA57737.1M7*
2377-12;Serine
from: 2377-12
O=C(N)CC(NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(/C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)[R])=O)C)=C\C3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)=O)C(O)=O—
152377-14QBA57737.1M8
2377-13;(E)-2,3-didehy-drotyrosine
from: 2377-13
OC([C@@H](NC(C(NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC(/C(N(C([C@@H](NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O)[C@H](O)[R])=O)C)=C\C3=CC=C(O)C=C3)=O)CC(C)C)=O)=O)[C@@H](O)C)=O)CC(N)=O)=O)CO)=O—
162377-15?—
2377-11/2377-12
from: 2377-11/2377-12
O=C(/C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@@H]([R])O)=O)C)=C\C2=CC=C(O)C=C2)N[C@@H](CC(C)C)C(N[C@H](CC3=CC=CC=C3)C(N[C@H](C(NC(C(O)=O)CC(N)=O)=O)[C@@H](O)C)=O)=O—
172377(2)?—
2377-11/2377-12
from: 2377-11/2377-12
O=C(/C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@@H](C)O)=O)C)=C\C2=CC=C(O)C=C2)N[C@@H](CC(C)C)C(N[C@H](CC3=CC=CC=C3)C(N[C@H](C(NC(C(O)=O)CC(N)=O)=O)[C@@H](O)C)=O)=O—
182377(3)?—
2377-11/2377-12
from: 2377-11/2377-12
O=C(/C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)CO)=O)C)=C\C2=CC=C(O)C=C2)N[C@@H](CC(C)C)C(N[C@H](CC3=CC=CC=C3)C(N[C@H](C(NC(C(O)=O)CC(N)=O)=O)[C@@H](O)C)=O)=O—
192377-16QBA57737.1TE
2377-14
from: 2377-14
O=C(/C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@@H]([R])OC2=O)=O)C)=C\C3=CC=C(O)C=C3)N[C@@H](CC(C)C)C(N[C@H](CC4=CC=CC=C4)C(N[C@H](C(NC(C(N[C@H]2CO)=O)CC(N)=O)=O)[C@@H](O)C)=O)=O—
202377(4)QBA57737.1TE
2377-14
from: 2377-14
O=C(/C(N(C([C@@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)[C@@H](C)OC2=O)=O)C)=C\C3=CC=C(O)C=C3)N[C@@H](CC(C)C)C(N[C@H](CC4=CC=CC=C4)C(N[C@H](C(NC(C(N[C@H]2CO)=O)CC(N)=O)=O)[C@@H](O)C)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture