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BGC0002376PKS

bombyxamycin A;bombyxamycin B

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (unknown)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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C27H33NO3

Gene Cluster Map52 genes · 113,079 bp

20 kb113.1 kb visible · 113,079 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
+Glutamic acid
Step 2
bomG,bomH
Step 3
(bomD,bomJ);bomO
Step 4
bomI
Step 5Load
bomE,bomM,bomP6
Step 6M1
bomP6
+Malonyl-CoA
Step 7M2
bomP6
+Malonyl-CoA
Step 8M3
bomP6
+Malonyl-CoA
Step 9M4
bomP5
+Malonyl-CoA
Step 10M5
bomP4
+Malonyl-CoA
Step 11M6
bomP4
+Malonyl-CoA
Inactive: KR
Step 12M7
bomP3
+Malonyl-CoA
Step 13M8
bomP2
+Methylmalonyl-CoA
Step 14M9
bomP2
+Malonyl-CoA
Step 15M10
bomP1
+Malonyl-CoA
Step 17
bomC
Step 16M11
bomP1
+Malonyl-CoA
Step 18TE
bomP1
Step 19
bomK
+2376(1)
Step 20
bomA/bomB
Step 21
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12376-1Start—
Glutamic acid
OC(C(CCC(O)=O)N)=O—
22376-2bomG,bomH—
2376-1
from: 2376-1
OC(C(C(C)C(O)=O)N)=O—
32376-3(bomD,bomJ);bomO—
2376-2
from: 2376-2
OC(C(C(C)C(O)=O)N)=O—
42376-4bomI—
2376-3
from: 2376-3
NCC(C)C(O)=O—
52376-5bomE,bomM,bomP6Loading
2376-4
from: 2376-4
OC(C(C)CN[R])=O—
62376-6bomP6M1
2376-5;Malonyl-CoA
from: 2376-5
OC(/C=C/C(C)CN[R])=O—
72376-7bomP6M2
2376-6;Malonyl-CoA
from: 2376-6
OC(/C=C/C=C/C(C)CN[R])=O—
82376-8bomP6M3
2376-7;Malonyl-CoA
from: 2376-7
OC(/C=C/C=C/C=C/C(C)CN[R])=O—
92376-9bomP5M4
2376-8;Malonyl-CoA
from: 2376-8
OC(/C=C/C=C/C=C/C=C/C(C)CN[R])=O—
102376-10bomP4M5
2376-9;Malonyl-CoA
from: 2376-9
O=C(O)/C=C/C=C/C=C/C=C/C=C/C(C)CN[R]—
112376-11bomP4M6
2376-10;Malonyl-CoA
from: 2376-10
O=C(CC(O)=O)/C=C/C=C/C=C/C=C/C=C/C(C)CN[R]{'Inactive':['KR']}
122376-12bomP3M7
2376-11;Malonyl-CoA
from: 2376-11
O=C(CC(CC(O)=O)O)/C=C/C=C/C=C/C=C/C=C/C(C)CN[R]—
132376-13bomP2M8
2376-12;Methylmalonyl-CoA
from: 2376-12
O=C(CC(C/C=C(C)/C(O)=O)O)/C=C/C=C/C=C/C=C/C=C/C(C)CN[R]—
142376-14bomP2M9
2376-13;Malonyl-CoA
from: 2376-13
O=C(CC(C/C=C(C)/C=C/C(O)=O)O)/C=C/C=C/C=C/C=C/C=C/C(C)CN[R]—
152376-15bomP1M10
2376-14;Malonyl-CoA
from: 2376-14
O=C(CC(C/C=C(C)/C=C/C=C/C(O)=O)O)/C=C/C=C/C=C/C=C/C=C/C(C)CN[R]—
162376-16bomP1M11
2376-15;Malonyl-CoA
from: 2376-15
O=C(CC(C/C=C(C)/C=C/C=C/C=C/C(O)=O)O)/C=C/C=C/C=C/C=C/C=C/C(C)CN[R]—
172376-17bomC—
2376-14
from: 2376-14
NCC(C)/C=C/C=C/C=C/C=C/C=C/C(CC(C/C=C(C)/C=C/C=C/C=C/C(O)=O)O)=O—
182376(1)bomP1TE
2376-15
from: 2376-15
OC(CC(/C=C/C=C\C=C/C=C/C=C\C(C)CN1)=O)C/C=C(C)\C=C\C=C/C=C\C1=O—
192376-18bomK—
2376(1)
OC(CC(/C=C/C=C\C=C/C=C/C=C\C(C)CN1)=O)C(O)/C=C(C)\C=C\C=C/C=C\C1=O—
202376-19bomA/bomB—
2376-18
from: 2376-18
OC(CC(/C=C/C=C\C=C/C=C/C=C\C(C)CN1)=O)C(O)C(C(C)/C=C/C=C\C=C/C1=O)O—
212376(2)?—
2376-19
from: 2376-19
C[C@]1([C@@H](O)[C@H](O)/C(O1)=C/C(/C=C/C=C\C=C/C=C/C=C\[C@@H](C)CN2)=O)/C=C/C=C\C=C/C2=O—
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