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BGC0002374PKS

pulvomycin B;pulvomycin C;pulvomycin D

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (unknown)
Total steps
23
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map35 genes · 103,658 bp

20 kb103.7 kb visible · 103,658 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TdTrans-AT docking
DH2Dehydratase (DH2)
ECHEnoyl-CoA hydratase
MTMethyltransferase
ACPβACP (β-branching)
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

23 steps · 22 edges
Step 1Load
pulE
+Malonyl-CoA
Step 20
Start
+di-O-methyl-d-fuc…
Step 23
pulQ,pulP,pulD,?
Step 2M1
pulE
+Malonyl-CoA
Step 3M2
pulE
+Malonyl-CoA
Step 4M3
pulE
+Malonyl-CoA
Step 5M4
pulE
+Malonyl-CoA
Step 6M5
pulE
+Methylmalonyl-CoA
Step 7M6
pulE
+Methylmalonyl-CoA
Step 8M7
pulE
+Malonyl-CoA
Step 9M8
pulF
+Malonyl-CoA
Step 10M9
pulF
+Malonyl-CoA
Step 11M10
pulF
+Malonyl-CoA
Step 12M11
pulG
+Malonyl-CoA
Step 13M12
pulG
+Methylmalonyl-CoA
Step 14M13
pulG
+Malonyl-CoA
Step 15M14
pulG
+Malonyl-CoA
Step 16M15
pulG
+Methylmalonyl-CoA
Step 17M16
pulH
+Malonyl-CoA
Step 18M17
pulH,pulC
Step 19
pulH
Step 21
pulQ,pulP,pulD
Step 22
pulQ,pulP,pulD
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12374-1pulELoading
Malonyl-CoA
OC(C)=O—
22374-2pulEM1
2374-1;Malonyl-CoA
from: 2374-1
OC(C[C@H](C)O)=O—
32374-3pulEM2
2374-2;Malonyl-CoA
from: 2374-2
OC(/C=C/C[C@H](C)O)=O—
42374-4pulEM3
2374-3;Malonyl-CoA
from: 2374-3
OC(/C=C/C=C/C[C@H](C)O)=O—
52374-5pulEM4
2374-4;Malonyl-CoA
from: 2374-4
OC(/C=C/C=C/C=C/C[C@H](C)O)=O—
62374-6pulEM5
2374-5;Methylmalonyl-CoA
from: 2374-5
OC(C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)=O—
72374-7pulEM6
2374-6;Methylmalonyl-CoA
from: 2374-6
OC(C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)=O—
82374-8pulEM7
2374-7;Malonyl-CoA
from: 2374-7
OC(C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)=O—
92374-9pulFM8
2374-8;Malonyl-CoA
from: 2374-8
OC(/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)=O—
102374-10pulFM9
2374-9;Malonyl-CoA
from: 2374-9
OC(/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)=O—
112374-11pulFM10
2374-10;Malonyl-CoA
from: 2374-10
OC(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)=O—
122374-12pulGM11
2374-11;Malonyl-CoA
from: 2374-11
OC(/C=C(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)\C)=O—
132374-13pulGM12
2374-12;Methylmalonyl-CoA
from: 2374-12
OC(/C=C/C=C(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)\C)=O—
142374-14pulGM13
2374-13;Malonyl-CoA
from: 2374-13
CC(/C=C/C=C(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)\C)=C\C(O)=O—
152374-15pulGM14
2374-14;Malonyl-CoA
from: 2374-14
O=C(O)C[C@H](O)/C(C)=C/C=C(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)\C—
162374-16pulGM15
2374-15;Methylmalonyl-CoA
from: 2374-15
CC(/C=C/C=C(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)\C)=C\[C@H](C(C)C(O)=O)O—
172374-17pulHM16
2374-16;Malonyl-CoA
from: 2374-16
CC(/C=C/C=C(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)\C)=C\[C@H](/C(C)=C/CC(O)=O)O—
182374-18pulH,pulCM17
2374-17
from: 2374-17
O[C@@H](CC(O)=O)/C(C)=C/C=C(C)/C=C(C[C@H](/C=C/C=C/C=C/C[C@@H](C(C)[C@@H](C(C)C(/C=C/C=C/C=C/C[C@H](C)O)=O)O)O)O)\C—
192374-19pulH—
2374-18
from: 2374-18
O[C@H](C(C)C(/C=C/C=C/C=C/C[C@@H](O)C)=O)C(C)[C@@H](O1)C/C=C/C=C/C=C/[C@H](O)C/C(C)=C/C=C/C(C)=C\C=C(C)\[C@@H](O)CC1=O—
202374-20Start—
di-O-methyl-d-fucose
O[C@H]1[C@H](OC)[C@@H](O)[C@@H](OC)[C@@H](C)O1—
212374(1)pulQ,pulP,pulD—
2374-19;2374-20
from: 2374-19, 2374-20
CO[C@@H]1[C@H](O)[C@@H](OC)[C@H](O[C@@H](C)[C@@H](O)/C=C/C=C/C=C/C(=O)[C@@H](C)[C@@H](O)[C@H](C)[C@@H]2C/C=C/C=C/C=C/[C@H](O)C(=O)/C(C)=C/C=C/C(C)=C/C=C(\C)[C@@H](O)CC(=O)O2)O[C@@H]1C—
222374(2)pulQ,pulP,pulD—
2374-19;2374-20
from: 2374-19, 2374-20
CO[C@@H]1[C@H](O)[C@@H](OC)[C@H](O[C@@H](C)[C@@H](O)/C=C/C=C/C=C/C(=O)[C@@H](C)[C@@H](O)[C@H](C)[C@@H]2C/C=C/C=C/C=C/[C@H](O)C(=O)/C(C)=C/C=C/C(C)=C\C=C(/C)[C@@H](O)CC(=O)O2)O[C@@H]1C—
232374(3)pulQ,pulP,pulD,?—
CO[C@@H]1[C@H](O)[C@@H](OC)[C@H](O[C@@H](C)[C@@H](O)/C=C/C=C/C=C/C(=O)[C@@H](C)[C@@H](O)[C@H](C)[C@@H]2C/C=C/C=C/C=C/C(=O)C(=O)/C(C)=C/C=C/C(C)=C\[C@@H](O)/C(C)=C\CC(=O)O2)O[C@@H]1C—
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