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BGC0002373NRPS

bonnevillamide D;bonnevillamide E

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
20
DOI
MIBiG entry
View on MIBiG ↗
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C44H64Cl2N6O14970.39 Da

Gene Cluster Map30 genes · 56,944 bp

CACACACACAAACACAC10 kb56.9 kb visible · 56,944 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
FkFkbH-like

Pathway Graphsteps arranged in biosynthetic order

20 steps · 19 edges
Step 1
Start
+L-Tyrosine
Step 3
Start
+5-methyl-L-Proline
Step 6
Start
+S-adenosyl-L-Meth…
Step 9
Start
+L-Valine
Step 2
bnvA,bnvN
Step 4
bnvG
Step 7
bnvL
Step 10
bnvH;bnvB
Step 5
bnvM
Step 8
bnvC
Step 11
bnvK
Step 13M1
bnvO
+Threonine
Step 12
bnvE/bnvJ
Step 14M2
bnvO
+Leucine
Step 15M3
bnvO
Step 16M4
bnvO
+Leucine
Step 17M5
bnvD
Step 18M6
bnvD
Step 19
?
Step 20
?
+2373(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions20 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12373-1Start—
L-Tyrosine
N[C@@H](CC1=CC=C(O)C=C1)C(O)=O—
22373-2bnvA,bnvN—
2373-1
from: 2373-1
CO/C(C(N)=O)=C\C1=CC(Cl)=C(O)C(Cl)=C1—
32373-3Start—
5-methyl-L-Proline
O=C([C@H]1N[C@H](C)CC1)O—
42373-4bnvG—
2373-3
from: 2373-3
O=C([C@H]1N[C@H](C)[C@@H](O)C1)O—
52373-5bnvM—
2373-4
from: 2373-4
O=C([C@H]1N[C@H](C)[C@@H](OC(C)=O)C1)O—
62373-6Start—
S-adenosyl-L-Methionine
O=C([C@@H](N)CC[S+](C)[Ado])O—
72373-7bnvL—
2373-6
from: 2373-6
OC([C@@H]1CCN1)=O—
82373-8bnvC—
2373-7
from: 2373-7
OC([C@@H]1C[C@H](C)N1)=O—
92373-9Start—
L-Valine
O=C([C@@H](N)C(C)C)O—
102373-10bnvH;bnvB—
2373-9
from: 2373-9
O=C([C@@H](N)C(C)C)O—
112373-11bnvK—
2373-10
from: 2373-10
O=C([C@@H](NO)C(C)C)O—
122373-12bnvE/bnvJ—
2373-11
from: 2373-11
O=C([C@@H](NO)C(C)C)O—
132373-13bnvOM1
2373-2;Threonine
from: 2373-2
CO/C(C(N[C@H](C(O)=O)[C@H](O)C)=O)=C\C1=CC(Cl)=C(O)C(Cl)=C1—
142373-14bnvOM2
2373-13;Leucine
from: 2373-13
CO/C(C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)[C@H](O)C)=O)=C\C1=CC(Cl)=C(O)C(Cl)=C1—
152373-15bnvOM3
2373-14;2373-5
from: 2373-14, 2373-5
CO/C(C(N[C@H](C(N[C@H](C(N1[C@@H](C[C@H](OC(C)=O)[C@H]1C)C(O)=O)=O)CC(C)C)=O)[C@H](O)C)=O)=C\C2=CC(Cl)=C(O)C(Cl)=C2—
162373-16bnvOM4
2373-15;Leucine
from: 2373-15
CO/C(C(N[C@H](C(N[C@H](C(N1[C@@H](C[C@H](OC(C)=O)[C@H]1C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC(C)C)=O)[C@H](O)C)=O)=C\C2=CC(Cl)=C(O)C(Cl)=C2—
172373-17bnvDM5
2373-16;2373-12
from: 2373-16, 2373-12
CO/C(C(N[C@H](C(N[C@H](C(N1[C@@H](C[C@H](OC(C)=O)[C@H]1C)C(N[C@H](C(N([C@H](C(O)=O)C(C)C)O)=O)CC(C)C)=O)=O)CC(C)C)=O)[C@H](O)C)=O)=C\C2=CC(Cl)=C(O)C(Cl)=C2—
182373-18bnvDM6
2373-17;2373-8
from: 2373-17, 2373-8
CO/C(C(N[C@H](C(N[C@H](C(N1[C@@H](C[C@H](OC(C)=O)[C@H]1C)C(N[C@H](C(N([C@H](C(N2[C@H](C(O)=O)C[C@@H]2C)=O)C(C)C)O)=O)CC(C)C)=O)=O)CC(C)C)=O)[C@H](O)C)=O)=C\C3=CC(Cl)=C(O)C(Cl)=C3—
192373(1)?—
2373-18
from: 2373-18
CO/C(C(N[C@H](C(N[C@H](C(N1[C@@H](C[C@H](OC(C)=O)[C@H]1C)C(N[C@H](C(N([C@H](C(N2[C@H](C(O)=O)C[C@@H]2C)=O)C(C)C)O)=O)CC(C)C)=O)=O)CC(C)C)=O)[C@H](O)C)=O)=C\C3=CC(Cl)=C(O)C(Cl)=C3—
202373(2)?—
2373(1)
CO/C(C(N/C(C(N[C@H](C(N1[C@@H](C[C@H](OC(C)=O)[C@H]1C)C(N[C@H](C(N([C@H](C(N2[C@H](C(O)=O)C[C@@H]2C)=O)C(C)C)O)=O)CC(C)C)=O)=O)CC(C)C)=O)=C\C)=O)=C\C3=CC(Cl)=C(O)C(Cl)=C3—
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