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BGC0002370NRPS

zelkovamycin B;zelkovamycin C;zelkovamycin D;zelkovamycin E

Producing organism
Actinomadura graeca
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinomadura
Biosynthetic class
NRPS (Type 1)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map30 genes · 59,991 bp

ACACACACyACAACCAA10 kb60.0 kb visible · 59,991 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
MTMethyltransferase
AmTAminotransferase IV

Pathway Graphsteps arranged in biosynthetic order

21 steps · 21 edges
Step 1
start
+L-Threonine
Step 2
?
Step 10
?
Step 3
?
Step 11
?
Step 4M1
AGRA3207_002708
+(2-aminobutyric a…
Step 5M2
AGRA3207_002708
+Threonine
Step 6M3
AGRA3207_002708
+Sarcosine
Step 7M4
AGRA3207_002707
+Alanine
Step 8M5
AGRA3207_002707, ?
+Cysteine
Step 9M6
AGRA3207_002707, ?
+Tryptophan
Step 12M7
AGRA3207_002706
Step 13M8
AGRA3207_002706
+Glycine
Step 14TE
AGRA3207_002706
Step 15TE
AGRA3207_002706
Step 16TE
AGRA3207_002706
Step 17
?
Step 18
?
Step 19
?
Step 20
?
Step 21
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12370-1start—
L-Threonine
C[C@@H](O)[C@H](N)C(O)=O—
22370-2?—
2370-1
from: 2370-1
CCC(C(O)=O)=O—
32370-3?—
2370-2
from: 2370-2
CCC(C(O)=O)N—
42370-4AGRA3207_002708M1
2370-3;(2-aminobutyric acid/Alanine)
from: 2370-3
N[C@@H](C(O)=O)C[R]—
52370-5AGRA3207_002708M2
2370-4;Threonine
from: 2370-4
N[C@@H](C(NC(C(C)O)C(O)=O)=O)C[R]—
62370-6AGRA3207_002708M3
2370-5;Sarcosine
from: 2370-5
N[C@@H](C(N/C(C(N(CC(O)=O)C)=O)=C\C)=O)C[R]—
72370-7AGRA3207_002707M4
2370-6;Alanine
from: 2370-6
N[C@@H](C(N/C(C(N(CC(N[C@@H](C(O)=O)C)=O)C)=O)=C\C)=O)C[R]—
82370-8AGRA3207_002707, ?M5
2370-7;Cysteine
from: 2370-7
N[C@@H](C(N/C(C(N(CC(N[C@@H](C1=NC(C(O)=O)=CS1)C)=O)C)=O)=C\C)=O)C[R]—
92370-9AGRA3207_002707, ?M6
2370-8;Tryptophan
from: 2370-8
N[C@@H](C(N/C(C(N(CC(N[C@@H](C1=NC(C(N[C@@H](CC2=CNC3=C2C(OC)=CC=C3)C(O)=O)=O)=CS1)C)=O)C)=O)=C\C)=O)C[R]—
102370-10?—
2370-1
from: 2370-1
CC(C(C(O)=O)N)=O—
112370-11?—
2370-10
from: 2370-10
CC([C@](C(O)=O)(C)N)=O—
122370-12AGRA3207_002706M7
2370-9;2370-11
from: 2370-9, 2370-11
N[C@@H](C(N/C(C(N(CC(N[C@@H](C1=NC(C(N[C@@H](CC2=CNC3=C2C(OC)=CC=C3)C(N[C@](C(C)=O)(C)C(O)=O)=O)=O)=CS1)C)=O)C)=O)=C\C)=O)C[R]—
132370-13AGRA3207_002706M8
2370-12;Glycine
from: 2370-12
N[C@@H](C(N/C(C(N(CC(N[C@@H](C1=NC(C(N[C@@H](CC2=CNC3=C2C(OC)=CC=C3)C(N[C@](C(C)=O)(C)C(NCC(O)=O)=O)=O)=O)=CS1)C)=O)C)=O)=C\C)=O)C[R]—
142370-14AGRA3207_002706TE
2370-13
from: 2370-13
O=C(CNC([C@@](C(C)=O)(C)NC1=O)=O)N[C@H](C[R])C(N/C(C(N(CC(N[C@H](C)C2=NC(C(N[C@H]1CC3=CNC4=C3C(OC)=CC=C4)=O)=CS2)=O)C)=O)=C\C)=O—
152370(1)AGRA3207_002706TE
2370-13
from: 2370-13
C[C@@H](NC(CNC([C@@](C(C)=O)(C)NC1=O)=O)=O)C(N/C(C(N(CC(N[C@H](C)C2=NC(C(N[C@H]1CC3=CNC4=C3C(OC)=CC=C4)=O)=CS2)=O)C)=O)=C\C)=O—
162370-15AGRA3207_002706TE
2370-13
from: 2370-13
O=C(CNC([C@@](C(C)=O)(C)NC1=O)=O)N[C@H](CC)C(N/C(C(N(CC(N[C@H](C)C2=NC(C(N[C@H]1CC3=CNC4=C3C(OC)=CC=C4)=O)=CS2)=O)C)=O)=C\C)=O—
172370(2)?—
2370-15
from: 2370-15
O=C(CNC([C@@](C(C)=O)(C)NC1=O)=O)N[C@H](CC)C(N/C(C(N(CC(N[C@H](C)C2=NC(C(N[C@H]1CC3=CNC4=C3C(OC)=C(O)C=C4)=O)=CS2)=O)C)=O)=C\C)=O—
182370(3)?—
2370-15
from: 2370-15
O=C(CNC([C@@](C(C)=O)(C)NC1=O)=O)N[C@H](CC)C(N/C(C(N(CC(N[C@H](C)C2=NC(C(N[C@H]1CC3=CNC4=C3C(OC)=CC=C4)=O)=CS2)=O)C)=O)=C\CO)=O—
192370-16?—
2370-15
from: 2370-15
O=C(CNC([C@@](C(CO)=O)(C)NC1=O)=O)N[C@H](CC)C(N/C(C(N(CC(N[C@H](C)C2=NC(C(N[C@H]1CC3=CNC4=C3C(OC)=CC=C4)=O)=CS2)=O)C)=O)=C\C)=O—
202370-17?—
2370-16
from: 2370-16
O=C(CNC([C@@](C(C=O)=O)(C)NC1=O)=O)N[C@H](CC)C(N/C(C(N(CC(N[C@H](C)C2=NC(C(N[C@H]1CC3=CNC4=C3C(OC)=CC=C4)=O)=CS2)=O)C)=O)=C\C)=O—
212370(4)?—
2370-17
from: 2370-17
O=C(CN1[C@@H](O)C2=O)N[C@H](CC)C(N/C(C(N(CC(N[C@H](C)C3=NC(C(N[C@@H](CC4=CNC5=C4C(OC)=CC=C5)C(N[C@]2(C)C1=O)=O)=O)=CS3)=O)C)=O)=C\C)=O—
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