NPdia

BGC0002367NRPS

rotihibin A

Producing organism: Streptomyces scabiei 87.22
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type 1)
Total steps: 9
DOI: 10.1128/Spectrum.00571-21
MIBiG entry: View on MIBiG ↗

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rotihibin A

Biosynthetic (core)

Biosynthetic (additional)

Transport

Domains

Ketoreductase (KR)

Acyl carrier protein (ACP)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

Epimerization (E)

Terminal reductase

CoA-ligase (CAL)

Aminotransferase III

TauD oxygenase

TIGR01720

9 steps · 8 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`2367-1`	start	—		`CCCCCCCCCC(O)=O`	—
2	`2367-2`	SCAB_3301,SCAB_3311,SCAB_3281	—	2367-1 from: 2367-1	`CCCCCCC/C=C\C(O)=O`	—
3	`2367-3`	SCAB_3321	M1	2367-2;Citrulline from: 2367-2	`CCCCCCC/C=C\C(NC(C(O)=O)CCCNC(N)=O)=O`	—
4	`2367-4`	SCAB_3321	M2	2367-3;Serine from: 2367-3	`CCCCCCC/C=C\C(NC(C(NC(C([H])O)C(O)=O)=O)CCCNC(N)=O)=O`	—
5	`2367-5`	SCAB_3321	M3	2367-4;(2,4)-di-amino butyric acid from: 2367-4	`CCCCCCC/C=C\C(NC(C(NC(C([H])O)C(NC(C(O)=O)CCN)=O)=O)CCCNC(N)=O)=O`	—
6	`2367-6`	SCAB_3321	M4	2367-5;hydroxy-Asparagine from: 2367-5	`CCCCCCC/C=C\C(NC(C(NC(C([H])O)C(NC(C(NC(C(O)=O)C(C(N)=O)O)=O)CCN)=O)=O)CCCNC(N)=O)=O`	—
7	`2367-7`	SCAB_3321	M5	2367-6;Asparagine from: 2367-6	`CCCCCCC/C=C\C(NC(C(NC(C([H])O)C(NC(C(NC(C(NC(CC(N)=O)CO)=O)C(C(N)=O)O)=O)CCN)=O)=O)CCCNC(N)=O)=O`	—
8	`2367-8`	SCAB_3221	M6	2367-7;Threonine from: 2367-7	`CCCCCCC/C=C\C(NC(C(NC(C([H])O)C(NC(C(NC(C(NC(CC(N)=O)CO)=O)C(C(N)=O)O)=O)CCNC(C(N)C(C)O)=O)=O)=O)CCCNC(N)=O)=O`	—
9	`2367`	?	—	2367-8 from: 2367-8	`CCCCCCC/C=C\C(NC(C(NC(C([H])O)C(NC(C(NC(C(NC(CC(N)=O)CO)=O)C(C(N)=O)O)=O)CCNC(C(N)C(C)O)=O)=O)=O)CCCNC(N)=O)=O`	—

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