NPdia

BGC0002364PKS

trichostatin RK

Producing organism: Streptomyces sp
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Unknown)
Total steps: 12
DOI: 10.1039/d0ob00617c
MIBiG entry: View on MIBiG ↗

Loading…

trichostatin RK

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Adenylation (A)

Thioesterase (TE)

Docking N-term

Docking C-term

Aminotransferase IV

12 steps · 11 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`2364-1`	AYM48695.1	—	Phosphoenolpyruvate;erythrose-4-phosphate	`O=C(C[C@@]([H])(O)[C@@](O)([H])[C@@](O)([H])CO[P])C(O)=O`	—
2	`2364-2`	?	—	2364-1 from: 2364-1	`OC1C=CC(C(O)=O)=C[C@H]1OC(C(O)=O)=C`	—
3	`2364-3`	AYM48694.1	—	2364-2 from: 2364-2	`NC1C=CC(C(O)=O)=C[C@H]1OC(C(O)=O)=C`	—
4	`2364-4`	AYM48692.1	—	2364-3 from: 2364-3	`NC1=CC=C(C(O)=O)C=C1`	—
5	`2364-5`	?,AYM48692.1	Loading	2364-4 from: 2364-4	`OC(C1=CC=C(N)C=C1)=O`	—
6	`2364-6`	?	M1	2364-5 from: 2364-5	`O=C(C1=CC=C(N)C=C1)[C@H](C)C(O)=O`	—
7	`2364-7`	AYM48704.1;AYM48703.1	M2	2364-6 from: 2364-6	`O=C(C1=CC=C(N)C=C1)[C@H](C)/C=C(C)/C(O)=O`	—
8	`2364-8`	AYM48702.1;AYM48703.1	M3	2364-7 from: 2364-7	`O=C(C1=CC=C(N)C=C1)[C@H](C)/C=C(C)/C=C/C(O)=O`	—
9	`2364-9`	AYM48702.1	TE	2364-8 from: 2364-8	`O=C(/C=C/C(C)=C/[C@H](C(C1=CC=C(C=C1)N)=O)C)O`	—
10	`2364-10`	AYM48697.1	—	2364-9 from: 2364-9	`O=C(/C=C/C(C)=C/[C@H](C(C1=CC=C(C=C1)N(C)C)=O)C)O`	—
11	`2364-11`	AYM48696.1	—	2364-10 from: 2364-10	`O=C(/C=C/C(C)=C/[C@H](C(C1=CC=C(C=C1)N(C)C)=O)C)N`	—
12	`2364`	?	—	2364-11 from: 2364-11	`O=C(/C=C/C(C)=C/[C@H](C(C1=CC=C(C=C1)N(C)C)=O)C)NC`	—

Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture