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BGC0002360NRPS

depsibosamycin B;depsibosamycin C;depsibosamycin D

Producing organism
Streptomyces aurantiacus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces aurantiacus group
Biosynthetic class
NRPS (Type 1)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map21 genes · 47,161 bp

AECACACACATauDCAECACATEA10 kb47.2 kb visible · 47,161 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
Start
+Tyrosine
Step 5M1
UEF20592.1, UEF20577.1
+Tyrosine, (carbamoyl/carbox…
Step 2
UEF20583.1
Step 6M2
UEF20591.1
+Tyrosine
Step 3
UEF20584.1
Step 7M3
UEF20578.1
+Leucine
Step 4
UEF20585.1
Step 8M4
UEF20578.1, UEF20579.1
+Aspartic acid
Step 9M5
UEF20578.1
+Serine
Step 10M6
UEF20580.1
Step 11M7
UEF20580.1
+Leucine
Step 12M8
UEF20580.1
+Glycine
Step 13TE
UEF20580.1
Step 14TE
UEF20580.1
Step 15TE
UEF20580.1
Step 16TE
UEF20580.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12360-1Start—
Tyrosine
OC([C@@H](N)CC1=CC=C(O)C=C1)=O—
22360-2UEF20583.1—
2360-1
from: 2360-1
OC([C@@H](N)CC1=C(O)C=C(O)C=C1)=O—
32360-3UEF20584.1—
2360-2
from: 2360-2
OC([C@@H](N)CC1=C(O)C=C(O)C=C1)=O—
42360-4UEF20585.1—
2360-3
from: 2360-3
OC([C@@H](N)CC1=C(OC)C=C(O)C=C1)=O—
52360-5UEF20592.1, UEF20577.1M1
Tyrosine;(carbamoyl/carboxyl carbamoyl)
OC([C@@H](N[R])CC1=CC=C(O)C=C1)=O—
62360-6UEF20591.1M2
2360-5;Tyrosine
from: 2360-5
O=C([C@@H](NC([C@@H](N[R])CC1=CC=C(O)C=C1)=O)CC2=CC=C(O)C=C2)O—
72360-7UEF20578.1M3
2360-6;Leucine
from: 2360-6
OC([C@H](NC([C@@H](NC([C@@H](N[R])CC1=CC=C(O)C=C1)=O)CC2=CC=C(O)C=C2)=O)CC(C)C)=O—
82360-8UEF20578.1, UEF20579.1M4
2360-7;Aspartic acid
from: 2360-7
O=C([C@H](NC([C@H](NC([C@@H](NC([C@@H](N[R])CC1=CC=C(O)C=C1)=O)CC2=CC=C(O)C=C2)=O)CC(C)C)=O)[C@H](C)C(O)=O)O—
92360-9UEF20578.1M5
2360-8;Serine
from: 2360-8
OC([C@H](NC([C@H](NC([C@H](NC([C@@H](NC([C@@H](N[R])CC1=CC=C(O)C=C1)=O)CC2=CC=C(O)C=C2)=O)CC(C)C)=O)[C@H](C)C(O)=O)=O)CO)=O—
102360-10UEF20580.1M6
2360-9;2360-4
from: 2360-9, 2360-4
OC([C@H](CC1=C(C=C(O)C=C1)OC)NC([C@H](NC([C@H](NC([C@H](NC([C@@H](NC([C@@H](N[R])CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)[C@H](C)C(O)=O)=O)CO)=O)=O—
112360-11UEF20580.1M7
2360-10;Leucine
from: 2360-10
CC(C)C[C@@H](NC([C@H](CC1=C(C=C(O)C=C1)OC)NC([C@H](NC([C@H](NC([C@H](NC([C@@H](NC([C@@H](N[R])CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)[C@H](C)C(O)=O)=O)CO)=O)=O)C(O)=O—
122360-12UEF20580.1M8
2360-11;Glycine
from: 2360-11
CC(C)C[C@@H](NC([C@H](CC1=C(C=C(O)C=C1)OC)NC([C@H](NC([C@H](NC([C@H](NC([C@@H](NC([C@@H](N[R])CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)[C@H](C)C(O)=O)=O)CO)=O)=O)C(NCC(O)=O)=O—
132360-13UEF20580.1TE
2360-12
from: 2360-12
CC(C)C[C@@H](NC([C@@H](CC1=C(C=C(O)C=C1)OC)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](N[R])CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)[C@@H](C)C(O)=O)=O)CO4)=O)=O)C(NCC4=O)=O—
142360(1)UEF20580.1TE
2360-12
from: 2360-12
CC(C)C[C@@H](NC([C@@H](CC1=C(C=C(O)C=C1)OC)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(N)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)[C@@H](C)C(O)=O)=O)CO4)=O)=O)C(NCC4=O)=O—
152360(2)UEF20580.1TE
2360-12
from: 2360-12
CC(C)C[C@@H](NC([C@@H](CC1=C(C=C(O)C=C1)OC)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(NC(O)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)[C@@H](C)C(O)=O)=O)CO4)=O)=O)C(NCC4=O)=O—
162360(3)UEF20580.1TE
2360-12
from: 2360-12
CC(C)C[C@@H](NC([C@@H](CC1=C(C=C(O)C=C1)OC)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(C)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)[C@@H](C)C(O)=O)=O)CO4)=O)=O)C(NCC4=O)=O—
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