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BGC0002357PKS

neomediomycin B

Producing organism
Streptomyces sp. RK95-74
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown);other (other)
Total steps
32
DOI
MIBiG entry
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neomediomycin B

Gene Cluster Map28 genes · 183,340 bp

50 kb183.3 kb visible · 183,340 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)

Pathway Graphsteps arranged in biosynthetic order

32 steps · 31 edges
Step 1
start
+γ-Aminobutyric ac…
Step 2M1
nmd1
+malonyl-CoA
Step 3M2
nmd1
+malonyl-CoA
Step 4M3
nmd1
+malonyl-CoA
Step 5M4
nmd1
+malonyl-CoA
Step 6M5
nmd1
+malonyl-CoA
Step 7M6
nmd1
+malonyl-CoA
Step 8M7
nmd1
+malonyl-CoA
Step 9M8
nmd1
+malonyl-CoA
Step 10M9
nmd2
+malonyl-CoA
Step 11M10
nmd2
+malonyl-CoA
Step 12M11
nmd3
+malonyl-CoA
Step 13M12
nmd3
+malonyl-CoA
Step 14M13
nmd3
+malonyl-CoA
Step 15M14
nmd3
+malonyl-CoA
Inactive: DH
Step 16M15
nmd4
+methylmalonyl-CoA
Inactive: KR
Step 17M16
nmd5
+malonyl-CoA
Step 18M17
nmd5
+malonyl-CoA
Step 19M18
nmd5
+malonyl-CoA
Step 20M19
nmd6
+malonyl-CoA
Step 21M20
nmd6
+malonyl-CoA
Step 22M21
nmd6
+malonyl-CoA
Step 23M22
nmd7
+methylmalonyl-CoA
Step 24M23
nmd7
+methylmalonyl-CoA
Step 25M24
nmd8
+malonyl-CoA
Step 26M25
nmd8
+malonyl-CoA
Step 27M26
nmd8
+malonyl-CoA
Step 28M27
nmd9
+malonyl-CoA
Step 29M28
nmd9
+malonyl-CoA
Step 30M29
nmd9
+methylmalonyl-CoA
Step 31M30
nmd9
+methylmalonyl-CoA
Step 32TE
nmd9
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions32 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12357-1start—
γ-Aminobutyric acid
OC(CCCN)=O—
22357-2nmd1M1
2357-1;malonyl-CoA
from: 2357-1
OC(C[C@H](O)CCCN)=O—
32357-3nmd1M2
2357-2;malonyl-CoA
from: 2357-2
OC(/C=C/C[C@H](O)CCCN)=O—
42357-4nmd1M3
2357-3;malonyl-CoA
from: 2357-3
OC(C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
52357-5nmd1M4
2357-4;malonyl-CoA
from: 2357-4
OC(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
62357-6nmd1M5
2357-5;malonyl-CoA
from: 2357-5
OC(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
72357-7nmd1M6
2357-6;malonyl-CoA
from: 2357-6
OC(/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
82357-8nmd1M7
2357-7;malonyl-CoA
from: 2357-7
OC(C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
92357-9nmd1M8
2357-8;malonyl-CoA
from: 2357-8
OC(C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
102357-10nmd2M9
2357-9;malonyl-CoA
from: 2357-9
OC(CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
112357-11nmd2M10
2357-10;malonyl-CoA
from: 2357-10
OC(C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
122357-12nmd3M11
2357-11;malonyl-CoA
from: 2357-11
OC(C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
132357-13nmd3M12
2357-12;malonyl-CoA
from: 2357-12
OC(/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
142357-14nmd3M13
2357-13;malonyl-CoA
from: 2357-13
OC(C[C@H](O)/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
152357-15nmd3M14
2357-14;malonyl-CoA
from: 2357-14
OC(C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O{'Inactive':['DH']}
162357-16nmd4M15
2357-15;methylmalonyl-CoA
from: 2357-15
OC([C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O{'Inactive':['KR']}
172357-17nmd5M16
2357-16;malonyl-CoA
from: 2357-16
OC(C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
182357-18nmd5M17
2357-17;malonyl-CoA
from: 2357-17
OC(/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
192357-19nmd5M18
2357-18;malonyl-CoA
from: 2357-18
OC(/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
202357-20nmd6M19
2357-19;malonyl-CoA
from: 2357-19
OC(/C=C/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@@H](O)CCC[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
212357-21nmd6M20
2357-20;malonyl-CoA
from: 2357-20
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C(O)=O)=O—
222357-22nmd6M21
2357-21;malonyl-CoA
from: 2357-21
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C(O)=O)=O—
232357-23nmd7M22
2357-22;methylmalonyl-CoA
from: 2357-22
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)C(O)=O)=O—
242357-24nmd7M23
2357-23;methylmalonyl-CoA
from: 2357-23
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C(O)=O)=O—
252357-25nmd8M24
2357-24;malonyl-CoA
from: 2357-24
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C(O)=O)=O—
262357-26nmd8M25
2357-25;malonyl-CoA
from: 2357-25
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CCC(O)=O)=O—
272357-27nmd8M26
2357-26;malonyl-CoA
from: 2357-26
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C(O)=O)=O—
282357-28nmd9M27
2357-27;malonyl-CoA
from: 2357-27
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C(O)=O)=O—
292357-29nmd9M28
2357-28;malonyl-CoA
from: 2357-28
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C/C(O)=O)=O—
302357-30nmd9M29
2357-29;methylmalonyl-CoA
from: 2357-29
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C/C=C(C)/C(O)=O)=O—
312357-31nmd9M30
2357-30;methylmalonyl-CoA
from: 2357-30
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C/C=C(C)/C=C/C(O)=O)=O—
322357nmd9TE
2357-31
from: 2357-31
NCCC[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CCC[C@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C/C=C(C)/C=C/C(O)=O)=O—
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