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BGC0002356PKS

mediomycin A

Producing organism
Streptomyces blastmyceticus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown);other (other)
Total steps
29
DOI
MIBiG entry
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mediomycin A

Gene Cluster Map25 genes · 161,523 bp

20 kb161.5 kb visible · 161,523 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

29 steps · 28 edges
Step 1
start
+γ-Aminobutyric ac…
Step 2M1
med1
+malonyl-CoA
Step 3M2
med1
+malonyl-CoA
Step 4M3
med1
+malonyl-CoA
Step 5M4
med1
+malonyl-CoA
Step 6M5
med1
+malonyl-CoA
Step 7M6
med2
+malonyl-CoA
Step 8M7
med2
+malonyl-CoA
Step 9M8
med3
+malonyl-CoA
Inactive: DH
Step 10M9
med3
+malonyl-CoA
Step 11M10
med3
+malonyl-CoA
Step 12M11
med3
+malonyl-CoA
Step 13M12
med3
+malonyl-CoA
Inactive: DH
Step 14M13
med4
+methylmalonyl-CoA
Inactive: KR
Step 15M14
med5
+malonyl-CoA
Step 16M15
med5
+malonyl-CoA
Step 17M16
med5
+malonyl-CoA
Step 18M17
med6
+malonyl-CoA
Step 19M18
med6
+malonyl-CoA
Step 20M19
med6
+malonyl-CoA
Step 21M20
med6
+malonyl-CoA
Step 22M21
med7
+methylmalonyl-CoA
Step 23M22
med7
+methylmalonyl-CoA
Step 24M23
med8
+malonyl-CoA
Step 25M24
med8
+malonyl-CoA
Step 26M25
med8
+malonyl-CoA
Step 27M26
med9
+malonyl-CoA
Step 28M27
med9
+methylmalonyl-CoA
Step 29TE
BAW35627.1, med9
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions29 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12356-1start—
γ-Aminobutyric acid
OC(CCCN)=O—
22356-2med1M1
2356-1;malonyl-CoA
from: 2356-1
OC(C[C@H](O)CCCN)=O—
32356-3med1M2
2356-2;malonyl-CoA
from: 2356-2
OC(C[C@H](O)C[C@H](O)CCCN)=O—
42356-4med1M3
2356-3;malonyl-CoA
from: 2356-3
OC(/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
52356-5med1M4
2356-4;malonyl-CoA
from: 2356-4
OC(C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
62356-6med1M5
2356-5;malonyl-CoA
from: 2356-5
OC(C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
72356-7med2M6
2356-6;malonyl-CoA
from: 2356-6
OC(/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
82356-8med2M7
2356-7;malonyl-CoA
from: 2356-7
OC(C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
92356-9med3M8
2356-8;malonyl-CoA
from: 2356-8
OC(C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O{'Inactive':['DH']}
102356-10med3M9
2356-9;malonyl-CoA
from: 2356-9
OC(C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
112356-11med3M10
2356-10;malonyl-CoA
from: 2356-10
OC(/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
122356-12med3M11
2356-11;malonyl-CoA
from: 2356-11
OC(C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O—
132356-13med3M12
2356-12;malonyl-CoA
from: 2356-12
OC(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O{'Inactive':['DH']}
142356-14med4M13
2356-13;methylmalonyl-CoA
from: 2356-13
OC([C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O)=O{'Inactive':['KR']}
152356-15med5M14
2356-14;malonyl-CoA
from: 2356-14
OC(C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O)=O—
162356-16med5M15
2356-15;malonyl-CoA
from: 2356-15
OC(/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O)=O—
172356-17med5M16
2356-16;malonyl-CoA
from: 2356-16
OC(/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O)=O—
182356-18med6M17
2356-17;malonyl-CoA
from: 2356-17
OC(/C=C/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O)=O—
192356-19med6M18
2356-18;malonyl-CoA
from: 2356-18
OC(/C=C/C=C/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCN)=O)=O—
202356-20med6M19
2356-19;malonyl-CoA
from: 2356-19
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C(O)=O)=O—
212356-21med6M20
2356-20;malonyl-CoA
from: 2356-20
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/C(O)=O)=O—
222356-22med7M21
2356-21;methylmalonyl-CoA
from: 2356-21
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)C(O)=O)=O—
232356-23med7M22
2356-22;methylmalonyl-CoA
from: 2356-22
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C(O)=O)=O—
242356-24med8M23
2356-23;malonyl-CoA
from: 2356-23
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C(O)=O)=O—
252356-25med8M24
2356-24;malonyl-CoA
from: 2356-24
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CCC(O)=O)=O—
262356-26med8M25
2356-25;malonyl-CoA
from: 2356-25
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C(O)=O)=O—
272356-27med9M26
2356-26;malonyl-CoA
from: 2356-26
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C(O)=O)=O—
282356-28med9M27
2356-27;methylmalonyl-CoA
from: 2356-27
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C(C)/C(O)=O)=O—
292356BAW35627.1, med9TE
2356-28
from: 2356-28
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C(C)/C(O)=O)=O—
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