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BGC0002355PKS

tetrafibricin

Producing organism
Streptomyces neyagawaensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown);other (other)
Total steps
20
DOI
MIBiG entry
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tetrafibricin

Gene Cluster Map9 genes · 144,171 bp

20 kb144.2 kb visible · 144,171 bp total
Biosynthetic (core)
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)

Pathway Graphsteps arranged in biosynthetic order

20 steps · 19 edges
Step 1
start
+γ-Aminobutyric ac…
Step 2M1
tfb1
+malonyl-CoA
Step 3M2
tfb1
+malonyl-CoA
Step 4M3
tfb1
+malonyl-CoA
Step 5M4
tfb1
+malonyl-CoA
Step 6M5
tfb1
+malonyl-CoA
Step 7M6
tfb1
+malonyl-CoA
Step 8M7
tfb2
+malonyl-CoA
Inactive: DH
Step 9M8
tfb2
+malonyl-CoA
Step 10M9
tfb3
+malonyl-CoA
Step 11M10
tfb3
+malonyl-CoA
Step 12M11
tfb3
+malonyl-CoA
Step 13M12
tfb3
+malonyl-CoA
Inactive: DH
Step 14M13
tfb4
+methylmalonyl-CoA
Inactive: KR
Step 15M14
tfb5
+malonyl-CoA
Step 16M15
tfb5
+malonyl-CoA
Step 17M16
tfb5
+malonyl-CoA
Step 18M17
tfb6
+malonyl-CoA
Step 19M18
tfb6
+malonyl-CoA
Step 20TE
tfb6
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions20 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12355-1start—
γ-Aminobutyric acid
OC(CCCN)=O—
22355-2tfb1M1
2355-1;malonyl-CoA
from: 2355-1
OC(C[C@H](O)CCCN)=O—
32355-3tfb1M2
2355-2;malonyl-CoA
from: 2355-2
OC(/C=C/C[C@H](O)CCCN)=O—
42355-4tfb1M3
2355-3;malonyl-CoA
from: 2355-3
OC(C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
52355-5tfb1M4
2355-4;malonyl-CoA
from: 2355-4
OC(/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
62355-6tfb1M5
2355-5;malonyl-CoA
from: 2355-5
OC(C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
72355-7tfb1M6
2355-6;malonyl-CoA
from: 2355-6
OC(C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
82355-8tfb2M7
2355-7;malonyl-CoA
from: 2355-7
OC(C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O{'Inactive':['DH']}
92355-9tfb2M8
2355-8;malonyl-CoA
from: 2355-8
OC(C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
102355-10tfb3M9
2355-9;malonyl-CoA
from: 2355-9
OC(/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
112355-11tfb3M10
2355-10;malonyl-CoA
from: 2355-10
OC(C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
122355-12tfb3M11
2355-11;malonyl-CoA
from: 2355-11
OC(C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O—
132355-13tfb3M12
2355-12;malonyl-CoA
from: 2355-12
OC(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O{'Inactive':['DH']}
142355-14tfb4M13
2355-13;methylmalonyl-CoA
from: 2355-13
OC([C@@H](C)C(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O{'Inactive':['KR']}
152355-15tfb5M14
2355-14;malonyl-CoA
from: 2355-14
OC(C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
162355-16tfb5M15
2355-15;malonyl-CoA
from: 2355-15
OC(/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
172355-17tfb5M16
2355-16;malonyl-CoA
from: 2355-16
OC(/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
182355-18tfb6M17
2355-17;malonyl-CoA
from: 2355-17
OC(/C=C/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
192355-19tfb6M18
2355-18;malonyl-CoA
from: 2355-18
OC(/C=C/C=C/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
202355tfb6TE
2355-19
from: 2355-19
OC(/C=C/C=C/C=C/C=C/C[C@H](O)[C@@H](C)C(C[C@H](O)C[C@H](O)C[C@H](O)/C=C/C[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)/C=C/C[C@H](O)CCCN)=O)=O—
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