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BGC0002349PKS

epemicin A;epemicin B

Producing organism
Kutzneria sp. CA-103260
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Kutzneria
Biosynthetic class
PKS (Type 1)
Total steps
24
DOI
MIBiG entry
View on MIBiG ↗
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C70H122N2O27

Gene Cluster Map42 genes · 128,719 bp

20 kb128.7 kb visible · 128,719 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

24 steps · 23 edges
Step 1M1
JJ691_101420
+methylmalonyl-CoA
Step 20
start
+α-L-vancosamine
Step 21
start
+aculexitriose
Step 22
start
+β-D-mannose
Step 2M2
JJ691_101420
+methylmalonyl-CoA
Step 3M3
JJ691_101420
+ethylmalonyl-CoA
Step 4M4
JJ691_101320
+malonyl-CoA
Step 5M5
JJ691_101320
+malonyl-CoA
Step 6M6
JJ691_101330
+methylmalonyl-CoA
Step 7M7
JJ691_101330
+methylmalonyl-CoA
Step 8M8
JJ691_101330
+malonyl-CoA
Step 9M9
JJ691_101330
+methylmalonyl-CoA
Step 10M10
JJ691_101330
+malonyl-CoA
Step 11M11
JJ691_101360
+malonyl-CoA
Step 12M12
JJ691_101360
+malonyl-CoA
Step 13M13
JJ691_101360
+malonyl-CoA
Step 14M14
JJ691_101360
+methylmalonyl-CoA
Step 15M15
JJ691_101360
+malonyl-CoA
Step 16M16
JJ691_101370
+malonyl-CoA
Step 17M17
JJ691_101370
+methylmalonyl-CoA
Step 18M18
JJ691_101380
+malonyl-CoA
Step 19TE
JJ691_101380
Step 23
?
Step 24
?
+2349(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions24 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12349-1JJ691_101420M1
methylmalonyl-CoA
OC(CC)=O—
22349-2JJ691_101420M2
2349-1;methylmalonyl-CoA
from: 2349-1
OC([C@@H](C)[C@@H](O)CC)=O—
32349-3JJ691_101420M3
2349-2;ethylmalonyl-CoA
from: 2349-2
OC([C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
42349-4JJ691_101320M4
2349-3;malonyl-CoA
from: 2349-3
OC(/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
52349-5JJ691_101320M5
2349-4;malonyl-CoA
from: 2349-4
OC(C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
62349-6JJ691_101330M6
2349-5;methylmalonyl-CoA
from: 2349-5
OC(/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
72349-7JJ691_101330M7
2349-6;methylmalonyl-CoA
from: 2349-6
OC([C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
82349-8JJ691_101330M8
2349-7;malonyl-CoA
from: 2349-7
OC(C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
92349-9JJ691_101330M9
2349-8;methylmalonyl-CoA
from: 2349-8
OC([C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
102349-10JJ691_101330M10
2349-9;malonyl-CoA
from: 2349-9
OC(C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
112349-11JJ691_101360M11
2349-10;malonyl-CoA
from: 2349-10
OC(C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
122349-12JJ691_101360M12
2349-11;malonyl-CoA
from: 2349-11
OC(C[C@@H](O)C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O—
132349-13JJ691_101360M13
2349-12;malonyl-CoA
from: 2349-12
OC(CC(C[C@@H](O)C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O)=O—
142349-14JJ691_101360M14
2349-13;methylmalonyl-CoA
from: 2349-13
OC([C@H](C)[C@H](O)CC(C[C@@H](O)C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O)=O—
152349-15JJ691_101360M15
2349-14;malonyl-CoA
from: 2349-14
OC(/C=C/[C@H](C)[C@H](O)CC(C[C@@H](O)C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O)=O—
162349-16JJ691_101370M16
2349-15;malonyl-CoA
from: 2349-15
OC(C[C@H](O)/C=C/[C@H](C)[C@H](O)CC(C[C@@H](O)C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O)=O—
172349-17JJ691_101370M17
2349-16;methylmalonyl-CoA
from: 2349-16
OC([C@H](C)[C@H](O)C[C@H](O)/C=C/[C@H](C)[C@H](O)CC(C[C@@H](O)C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O)=O—
182349-18JJ691_101380M18
2349-17;malonyl-CoA
from: 2349-17
O=C(/C=C/[C@H](C)[C@H](O)C[C@H](O)/C=C/[C@H](C)[C@H](O)CC(C[C@@H](O)C[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](O)/C(C)=C/C[C@H](O)/C=C/[C@H](CC)[C@@H](O)[C@@H](C)[C@@H](O)CC)=O)O—
192349-19JJ691_101380TE
2349-18
from: 2349-18
C[C@@H](/C=C/C(O[C@H](/C=C/[C@H](CC)[C@H]([C@@H](C)[C@H](CC)O)O)C/C=C(C)/[C@H]1O)=O)[C@H](O)C[C@H](O)/C=C/[C@@H]([C@H](O)CC2(O)OC(C[C@H](O)C2)C[C@@H](O)[C@@H]([C@H](O)C[C@@H](O)[C@@H]1C)C)C—
202349-20start—
α-L-vancosamine
O[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1—
212349-21start—
aculexitriose
O[C@H]1[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](OC3C[C@@H](N)[C@H](O)[C@@H](C)O3)[C@H](O)[C@@H](C)O1—
222349-22start—
β-D-mannose
O[C@@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O—
232349(1)?—
2349-19;2349-20;2349-21
from: 2349-19, 2349-20, 2349-21
C[C@@H](/C=C/C(O[C@H](/C=C/[C@H](CC)[C@H]([C@@H](C)[C@H](CC)O[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1)O)C/C=C(C)/[C@H]2O)=O)[C@H](O)C[C@H](O)/C=C/[C@@H]([C@H](O[C@H]3[C@H](O[C@@H]4O[C@H](C)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](OC5C[C@@H](N)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O3)CC6(O)O[C@](C[C@H](O)[C@H]6O)([H])C[C@@H](O)[C@@H]([C@H](O)C[C@@H](O)[C@@H]2C)C)C—
242349(2)?—
2349-22;2349(1)
from: 2349-22
C[C@@H](/C=C/C(O[C@H](/C=C/[C@H](CC)[C@H]([C@@H](C)[C@H](CC)O[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1)O)C/C=C(C)/[C@H]2O)=O)[C@H](O)C[C@H](O)/C=C/[C@@H]([C@H](O[C@H]3[C@H](O[C@@H]4O[C@H](C)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](OC5C[C@@H](N)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O3)CC6(O)O[C@](C[C@H](O)[C@H]6O)([H])C[C@@H](O)[C@@H]([C@H](O)C[C@@H](O[C@H]7[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H]2C)C)C—
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